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Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance

Y Temel, A Blokland, L Ackermans, Paul Boon UGent, VHJM Van Kranen-Mastenbroek, EAM Beuls, GH Spincemaille and V Visser-Vandewalle (2006) EXPERIMENTAL BRAIN RESEARCH. 169(3). p.389-399
abstract
The aim of the present study was to assess the effect of bilateral subthalamic nucleus (STN) stimulation and dopaminergic medication on speed of mental processing and motor function. Thirty-nine patients suffering from advanced Parkinson disease (PD) were operated on. Motor function and reaction time (RT) performance [simple RT (SRT) and complex RT (CRT)] were evaluated under four experimental conditions with stimulation (stim) and medication (med) on and off: stim-on/med-on, stim-on/med-off, stim-off/med-off and stim-off/med-on. In the last condition, the patients received either low medication (usual dose) or high medication (suprathreshold dose). STN stimulation improved the motor performance in the SRT and CRT tasks. Furthermore, STN deep brain stimulation (DBS) also improved response preparation as shown by the significant improvement of the RT performance in the SRT task. This effect of STN DBS on the RT performance in the SRT task was greater as compared with the CRT task. This is due to the more complex information processing that is required in the CRT task as compared to the SRT task. These data suggest that treatment of STN hyperactivity by DBS improves motor function, confirming earlier reports, but has a differential effect on cognitive functions. The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
EXPERIMENTAL BRAIN RESEARCH
Exp. Brain Res.
volume
169
issue
3
pages
389 - 399
publisher
Springer
place of publication
233 SPRING STREET, NEW YORK, NY 10013 USA
Web of Science type
Article
Web of Science id
000235487500010
JCR category
NEUROSCIENCES
JCR impact factor
1.959 (2006)
JCR rank
128/199 (2006)
JCR quartile
3 (2006)
ISSN
0014-4819
DOI
10.1007/s00221-005-0151-6
language
English
UGent publication?
no
classification
A1
id
668400
handle
http://hdl.handle.net/1854/LU-668400
date created
2009-05-27 11:28:05
date last changed
2009-05-28 13:16:19
@article{668400,
  abstract     = {The aim of the present study was to assess the effect of bilateral subthalamic nucleus (STN) stimulation and dopaminergic medication on speed of mental processing and motor function. Thirty-nine patients suffering from advanced Parkinson disease (PD) were operated on. Motor function and reaction time (RT) performance [simple RT (SRT) and complex RT (CRT)] were evaluated under four experimental conditions with stimulation (stim) and medication (med) on and off: stim-on/med-on, stim-on/med-off, stim-off/med-off and stim-off/med-on. In the last condition, the patients received either low medication (usual dose) or high medication (suprathreshold dose). STN stimulation improved the motor performance in the SRT and CRT tasks. Furthermore, STN deep brain stimulation (DBS) also improved response preparation as shown by the significant improvement of the RT performance in the SRT task. This effect of STN DBS on the RT performance in the SRT task was greater as compared with the CRT task. This is due to the more complex information processing that is required in the CRT task as compared to the SRT task. These data suggest that treatment of STN hyperactivity by DBS improves motor function, confirming earlier reports, but has a differential effect on cognitive functions. The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits.},
  author       = {Temel, Y and Blokland, A and Ackermans, L and Boon, Paul and Van Kranen-Mastenbroek, VHJM and Beuls, EAM and Spincemaille, GH and Visser-Vandewalle, V},
  issn         = {0014-4819},
  journal      = {EXPERIMENTAL BRAIN RESEARCH},
  language     = {eng},
  number       = {3},
  pages        = {389--399},
  publisher    = {Springer},
  title        = {Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance},
  url          = {http://dx.doi.org/10.1007/s00221-005-0151-6},
  volume       = {169},
  year         = {2006},
}

Chicago
Temel, Y, A Blokland, L Ackermans, Paul Boon, VHJM Van Kranen-Mastenbroek, EAM Beuls, GH Spincemaille, and V Visser-Vandewalle. 2006. “Differential Effects of Subthalamic Nucleus Stimulation in Advanced Parkinson Disease on Reaction Time Performance.” Experimental Brain Research 169 (3): 389–399.
APA
Temel, Y, Blokland, A., Ackermans, L., Boon, P., Van Kranen-Mastenbroek, V., Beuls, E., Spincemaille, G., et al. (2006). Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance. EXPERIMENTAL BRAIN RESEARCH, 169(3), 389–399.
Vancouver
1.
Temel Y, Blokland A, Ackermans L, Boon P, Van Kranen-Mastenbroek V, Beuls E, et al. Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance. EXPERIMENTAL BRAIN RESEARCH. 233 SPRING STREET, NEW YORK, NY 10013 USA: Springer; 2006;169(3):389–99.
MLA
Temel, Y, A Blokland, L Ackermans, et al. “Differential Effects of Subthalamic Nucleus Stimulation in Advanced Parkinson Disease on Reaction Time Performance.” EXPERIMENTAL BRAIN RESEARCH 169.3 (2006): 389–399. Print.