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Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review

Y Temel, A Kessels, S Tan, A Topdag, Paul Boon UGent and V Visser-Vandewalle (2006) PARKINSONISM & RELATED DISORDERS. 12(5). p.265-272
abstract
Introduction. The long-lasting beneficial effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor function have now largely been acknowledged. Whereas behavioural changes have been demonstrated in certain case reports and small case series, some authors have not observed behavioural changes at all. The extent to which these changes occur has not yet been established. The aim of the present study was to systematically analyse behavioural changes of bilateral STN DBS. Materials and methods. A structured Medline search was conducted using previously described methods. Studies were selected according to specific in- and exclusion criteria. Data on patients, surgical technique, outcome and complications were collected and pooled. Results. In total 1398 patients who underwent bilateral STN DBS were included. The total cumulative follow-up period was 1480 patient-years. Cognitive problems were seen in 41%, depression in 8%, and (hypo)mania in 4% of the patients. Anxiety disorders were observed in less than 2%, and personality changes, hypersexuality, apathy, anxiety, and aggressiveness were observed in less than 0.5% of the group studied. About half of the patients did not experience behavioural changes. Conclusion. Caregivers should be aware of the extent of these behavioural changes and a risk/benefit evaluation should be performed for individual patients. (c) 2006 Elsevier Ltd. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
PARKINSONISM & RELATED DISORDERS
Parkinsonism Relat. Disord.
volume
12
issue
5
pages
265 - 272
publisher
ELSEVIER SCI LTD, THE BOULEVARD
place of publication
LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Web of Science type
Article
Web of Science id
000238603000001
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.308 (2006)
JCR rank
57/146 (2006)
JCR quartile
2 (2006)
ISSN
1353-8020
DOI
10.1016/j.parkreldis.2006.01.004
language
English
UGent publication?
no
classification
A1
id
668364
handle
http://hdl.handle.net/1854/LU-668364
date created
2009-05-27 11:21:53
date last changed
2009-05-28 13:13:55
@article{668364,
  abstract     = {Introduction. The long-lasting beneficial effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor function have now largely been acknowledged. Whereas behavioural changes have been demonstrated in certain case reports and small case series, some authors have not observed behavioural changes at all. The extent to which these changes occur has not yet been established. The aim of the present study was to systematically analyse behavioural changes of bilateral STN DBS.
Materials and methods. A structured Medline search was conducted using previously described methods. Studies were selected according to specific in- and exclusion criteria. Data on patients, surgical technique, outcome and complications were collected and pooled.

Results. In total 1398 patients who underwent bilateral STN DBS were included. The total cumulative follow-up period was 1480 patient-years. Cognitive problems were seen in 41\%, depression in 8\%, and (hypo)mania in 4\% of the patients. Anxiety disorders were observed in less than 2\%, and personality changes, hypersexuality, apathy, anxiety, and aggressiveness were observed in less than 0.5\% of the group studied. About half of the patients did not experience behavioural changes.

Conclusion. Caregivers should be aware of the extent of these behavioural changes and a risk/benefit evaluation should be performed for individual patients. (c) 2006 Elsevier Ltd. All rights reserved.},
  author       = {Temel, Y and Kessels, A and Tan, S and Topdag, A and Boon, Paul and Visser-Vandewalle, V},
  issn         = {1353-8020},
  journal      = {PARKINSONISM \& RELATED DISORDERS},
  language     = {eng},
  number       = {5},
  pages        = {265--272},
  publisher    = {ELSEVIER SCI LTD, THE BOULEVARD},
  title        = {Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review},
  url          = {http://dx.doi.org/10.1016/j.parkreldis.2006.01.004},
  volume       = {12},
  year         = {2006},
}

Chicago
Temel, Y, A Kessels, S Tan, A Topdag, Paul Boon, and V Visser-Vandewalle. 2006. “Behavioural Changes After Bilateral Subthalamic Stimulation in Advanced Parkinson Disease: A Systematic Review.” Parkinsonism & Related Disorders 12 (5): 265–272.
APA
Temel, Y, Kessels, A., Tan, S., Topdag, A., Boon, P., & Visser-Vandewalle, V. (2006). Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review. PARKINSONISM & RELATED DISORDERS, 12(5), 265–272.
Vancouver
1.
Temel Y, Kessels A, Tan S, Topdag A, Boon P, Visser-Vandewalle V. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review. PARKINSONISM & RELATED DISORDERS. LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND: ELSEVIER SCI LTD, THE BOULEVARD; 2006;12(5):265–72.
MLA
Temel, Y, A Kessels, S Tan, et al. “Behavioural Changes After Bilateral Subthalamic Stimulation in Advanced Parkinson Disease: A Systematic Review.” PARKINSONISM & RELATED DISORDERS 12.5 (2006): 265–272. Print.