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Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions

Deirdre Cabooter, François Lestremau, André De Villiers, Ken Broeckhoven, Frederic Lynen UGent, Patrick Sandra UGent and Gert Desmet (2009) JOURNAL OF CHROMATOGRAPHY A. 1216(18). p.3895-3903
abstract
The present study investigates how strong the kinetic plot method is influenced by the changes in plate height, retention factor and apparent column permeability that arise under conditions of very high pressure. More precisely, the study investigates how well a set of performance measurements conducted on a single short column can be used to predict the performance of a long sequence of coupled columns. This has been investigated for the two practically most relevant thermal conditions, i.e., that of a forced-air oven and that of a still-air oven. Measuring column performance data for acetophenone and benzene on a series of coupled 3.5 mu M columns that could be operated up to 1000 bar, it was found that the kinetic plot method provides accurate predictions of time versus efficiency for the still-air oven systems. over the entire range of investigated pressures and column lengths (up to 60 cm), provided k' and K-v0 are evaluated at the maximal pressure. For the forced-air oven which leads to worse performances than the still-air oven, the kinetic plot prediction is less accurate, partly because the thermal conditions (near-isothermal) tend to vary if the number of coupled columns increases. The fact that the thermal conditions of the column wall might vary with the column length is an additional complexity making very-high pressure separations less predictable and harder to interpret and model.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
JOURNAL OF CHROMATOGRAPHY A
J. Chromatogr. A
volume
1216
issue
18
pages
3895 - 3903
Web of Science type
Article
Web of Science id
000265699900029
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
4.101 (2009)
JCR rank
4/70 (2009)
JCR quartile
1 (2009)
ISSN
0021-9673
DOI
10.1016/j.chroma.2009.02.079
language
English
UGent publication?
no
classification
A1
id
668165
handle
http://hdl.handle.net/1854/LU-668165
date created
2009-05-27 10:59:00
date last changed
2009-05-27 11:04:52
@article{668165,
  abstract     = {The present study investigates how strong the kinetic plot method is influenced by the changes in plate height, retention factor and apparent column permeability that arise under conditions of very high pressure. More precisely, the study investigates how well a set of performance measurements conducted on a single short column can be used to predict the performance of a long sequence of coupled columns. This has been investigated for the two practically most relevant thermal conditions, i.e., that of a forced-air oven and that of a still-air oven. Measuring column performance data for acetophenone and benzene on a series of coupled 3.5 mu M columns that could be operated up to 1000 bar, it was found that the kinetic plot method provides accurate predictions of time versus efficiency for the still-air oven systems. over the entire range of investigated pressures and column lengths (up to 60 cm), provided k' and K-v0 are evaluated at the maximal pressure. For the forced-air oven which leads to worse performances than the still-air oven, the kinetic plot prediction is less accurate, partly because the thermal conditions (near-isothermal) tend to vary if the number of coupled columns increases. The fact that the thermal conditions of the column wall might vary with the column length is an additional complexity making very-high pressure separations less predictable and harder to interpret and model.},
  author       = {Cabooter, Deirdre and Lestremau, Fran\c{c}ois and De Villiers, Andr{\'e} and Broeckhoven, Ken and Lynen, Frederic and Sandra, Patrick and Desmet, Gert},
  issn         = {0021-9673},
  journal      = {JOURNAL OF CHROMATOGRAPHY A},
  language     = {eng},
  number       = {18},
  pages        = {3895--3903},
  title        = {Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions},
  url          = {http://dx.doi.org/10.1016/j.chroma.2009.02.079},
  volume       = {1216},
  year         = {2009},
}

Chicago
Cabooter, Deirdre, François Lestremau, André De Villiers, Ken Broeckhoven, Frederic Lynen, Patrick Sandra, and Gert Desmet. 2009. “Investigation of the Validity of the Kinetic Plot Method to Predict the Performance of Coupled Column Systems Operated at Very High Pressures Under Different Thermal Conditions.” Journal of Chromatography A 1216 (18): 3895–3903.
APA
Cabooter, D., Lestremau, F., De Villiers, A., Broeckhoven, K., Lynen, F., Sandra, P., & Desmet, G. (2009). Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions. JOURNAL OF CHROMATOGRAPHY A, 1216(18), 3895–3903.
Vancouver
1.
Cabooter D, Lestremau F, De Villiers A, Broeckhoven K, Lynen F, Sandra P, et al. Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions. JOURNAL OF CHROMATOGRAPHY A. 2009;1216(18):3895–903.
MLA
Cabooter, Deirdre, François Lestremau, André De Villiers, et al. “Investigation of the Validity of the Kinetic Plot Method to Predict the Performance of Coupled Column Systems Operated at Very High Pressures Under Different Thermal Conditions.” JOURNAL OF CHROMATOGRAPHY A 1216.18 (2009): 3895–3903. Print.