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Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography

Alberto Dos Santos Pereira UGent, Marc Schelfaut UGent, Frederic Lynen UGent and Patrick Sandra UGent (2008) JOURNAL OF CHROMATOGRAPHY A. 1185(1). p.78-84
abstract
Reversed-phase liquid chromatography was coupled to a multi-detection system composed of ultraviolet (UV) detection, evaporative laser scattering detection (ELSD) and inductively coupled plasma mass spectrometry (ICP-MS). By applying the principle of post-column solvent compensation, the organic modifier content was kept constant in ELSD and ICP-MS under gradient elution. Chlorine (Cl-35), bromine (Br-79 and Br-81) and sulfur (S-34) were monitored in several pharmaceutical compounds. The limit of quantitation (LOQ) was 80 ng/rnL for chlorine (chlorpropamide) and 2 ng/mL for bromine (bromazepam). Calibration graphs were linear from 1.0 mu g/mL to 100 mu g/mL for chlorpropamide (r(2) 0.990) and from 10 ng/mL to 500 ng/mL for bromazeparn (r(2) 0.996). The low LOQ value for bromine allows to quantify bromine in pharmaceutical samples below the 0.05% level of the active pharmaceutical ingredient.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
JOURNAL OF CHROMATOGRAPHY A
J. Chromatogr. A
volume
1185
issue
1
pages
78 - 84
Web of Science type
Article
Web of Science id
000254322700010
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.756 (2008)
JCR rank
6/70 (2008)
JCR quartile
1 (2008)
ISSN
0021-9673
DOI
10.1016/j.chroma.2008.01.030
language
English
UGent publication?
yes
classification
A1
id
667980
handle
http://hdl.handle.net/1854/LU-667980
date created
2009-05-27 10:33:31
date last changed
2009-05-27 10:37:38
@article{667980,
  abstract     = {Reversed-phase liquid chromatography was coupled to a multi-detection system composed of ultraviolet (UV) detection, evaporative laser scattering detection (ELSD) and inductively coupled plasma mass spectrometry (ICP-MS). By applying the principle of post-column solvent compensation, the organic modifier content was kept constant in ELSD and ICP-MS under gradient elution. Chlorine (Cl-35), bromine (Br-79 and Br-81) and sulfur (S-34) were monitored in several pharmaceutical compounds. The limit of quantitation (LOQ) was 80 ng/rnL for chlorine (chlorpropamide) and 2 ng/mL for bromine (bromazepam). Calibration graphs were linear from 1.0 mu g/mL to 100 mu g/mL for chlorpropamide (r(2) 0.990) and from 10 ng/mL to 500 ng/mL for bromazeparn (r(2) 0.996). The low LOQ value for bromine allows to quantify bromine in pharmaceutical samples below the 0.05\% level of the active pharmaceutical ingredient.},
  author       = {Dos Santos Pereira, Alberto and Schelfaut, Marc and Lynen, Frederic and Sandra, Patrick},
  issn         = {0021-9673},
  journal      = {JOURNAL OF CHROMATOGRAPHY A},
  language     = {eng},
  number       = {1},
  pages        = {78--84},
  title        = {Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography},
  url          = {http://dx.doi.org/10.1016/j.chroma.2008.01.030},
  volume       = {1185},
  year         = {2008},
}

Chicago
Dos Santos Pereira, Alberto, Marc Schelfaut, Frederic Lynen, and Patrick Sandra. 2008. “Design and Evaluation of a Multi-detection System Composed of Ultraviolet, Evaporative Light Scattering and Inductively Coupled Plasma Mass Spectrometry Detection for the Analysis of Pharmaceuticals by Liquid Chromatography.” Journal of Chromatography A 1185 (1): 78–84.
APA
Dos Santos Pereira, A., Schelfaut, M., Lynen, F., & Sandra, P. (2008). Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1185(1), 78–84.
Vancouver
1.
Dos Santos Pereira A, Schelfaut M, Lynen F, Sandra P. Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography. JOURNAL OF CHROMATOGRAPHY A. 2008;1185(1):78–84.
MLA
Dos Santos Pereira, Alberto, Marc Schelfaut, Frederic Lynen, et al. “Design and Evaluation of a Multi-detection System Composed of Ultraviolet, Evaporative Light Scattering and Inductively Coupled Plasma Mass Spectrometry Detection for the Analysis of Pharmaceuticals by Liquid Chromatography.” JOURNAL OF CHROMATOGRAPHY A 1185.1 (2008): 78–84. Print.