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Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction

(2008) ANALYTICA CHIMICA ACTA. 614(2). p.201-207
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Abstract
This article presents a method employing stir bar sorptive extraction (SBSE) with in situ derivatization, in combination with either thermal or liquid desorption on-line coupled to gas chromatography-mass spectrometry for the analysis of fluoxetine in plasma samples. Ethyl chloroformate was employed as derivatizing agent producing symmetrical peaks. Parameters such as solvent polarity, time for analyte desorption, and extraction time, were evaluated. During the validation process, the developed method presented specificity, linearity (R-2 > 0.99), precision (R.S.D. < 15%), and limits of quantification (LOQ) of 30 and 1.37 pg mL(-1), when liquid and thermal desorption were employed, respectively. This simple and highly sensitive method showed to be adequate for the measurement-of fluoxetine in typical and trace concentration levels.

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Chicago
Fernandes, Christian, Els Van Hoeck, Patrick Sandra, and Fernando M. Lancas. 2008. “Determination of Fluoxetine in Plasma by Gas Chromatography-mass Spectrometry Using Stir Bar Sorptive Extraction.” Analytica Chimica Acta 614 (2): 201–207.
APA
Fernandes, C., Van Hoeck, E., Sandra, P., & Lancas, F. M. (2008). Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction. ANALYTICA CHIMICA ACTA, 614(2), 201–207.
Vancouver
1.
Fernandes C, Van Hoeck E, Sandra P, Lancas FM. Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction. ANALYTICA CHIMICA ACTA. 2008;614(2):201–7.
MLA
Fernandes, Christian et al. “Determination of Fluoxetine in Plasma by Gas Chromatography-mass Spectrometry Using Stir Bar Sorptive Extraction.” ANALYTICA CHIMICA ACTA 614.2 (2008): 201–207. Print.
@article{667902,
  abstract     = {This article presents a method employing stir bar sorptive extraction (SBSE) with in situ derivatization, in combination with either thermal or liquid desorption on-line coupled to gas chromatography-mass spectrometry for the analysis of fluoxetine in plasma samples. Ethyl chloroformate was employed as derivatizing agent producing symmetrical peaks. Parameters such as solvent polarity, time for analyte desorption, and extraction time, were evaluated. During the validation process, the developed method presented specificity, linearity (R-2 {\textrangle} 0.99), precision (R.S.D. {\textlangle} 15\%), and limits of quantification (LOQ) of 30 and 1.37 pg mL(-1), when liquid and thermal desorption were employed, respectively. This simple and highly sensitive method showed to be adequate for the measurement-of fluoxetine in typical and trace concentration levels.},
  author       = {Fernandes, Christian and Van Hoeck, Els and Sandra, Patrick and Lancas, Fernando M.},
  issn         = {0003-2670},
  journal      = {ANALYTICA CHIMICA ACTA},
  language     = {eng},
  number       = {2},
  pages        = {201--207},
  title        = {Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction},
  url          = {http://dx.doi.org/10.1016/j.aca.2008.03.036},
  volume       = {614},
  year         = {2008},
}

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