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Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns

(2008) JOURNAL OF CHROMATOGRAPHY A. 1204(1). p.1-10
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Abstract
To contribute to the current debate about the "ideal" particle size range (sub-2 mu m vs. supra-2 mu m), the present study compares the kinetic performance of some commercially available sub-2 mu m and 3.5 mu m particles used under quasi-adiabatic conditions via the kinetic plot method. Under the adopted assumption that viscous heating effects can be neglected (which is uncertain in a pressure range above 400 bar), the obtained kinetic plots show that, provided each particle size is used in a column with properly optimized length, the gain in separation speed that sub-2 mu m particle columns might have over maximally performing 2.5 mu m particle columns is very small. Sub-2 mu m particle columns can only yield a gain in separation speed in the range of high-speed/low-resolution-separations (total time based on k = 10 below 5 or 10min). And even in this range, the actual gain that can be expected is only marginally small (only a few %). The present study hence suggests that the development and the use of particles in the 2-3 mu m range should deserve more attention than it did in the past few years. However, to be competitive, this 2-3 mu m material should be packed in relatively long columns, with a packing quality matching that of the current best performing 3.5 mu m particle columns. The supra-2 mu m particles should also be able to withstand the same pressures as the sub-2 mu m particle material one is comparing it to.

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Chicago
Cabooter, Deirdre, Jeroen Billen, Herman Terryn, Frederic Lynen, Patrick Sandra, and Gert Desmet. 2008. “Kinetic Plot and Particle Size Distribution Analysis to Discuss the Performance Limits of Sub-2 Mu m and Supra-2 Mu m Particle Columns.” Journal of Chromatography A 1204 (1): 1–10.
APA
Cabooter, D., Billen, J., Terryn, H., Lynen, F., Sandra, P., & Desmet, G. (2008). Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns. JOURNAL OF CHROMATOGRAPHY A, 1204(1), 1–10.
Vancouver
1.
Cabooter D, Billen J, Terryn H, Lynen F, Sandra P, Desmet G. Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns. JOURNAL OF CHROMATOGRAPHY A. 2008;1204(1):1–10.
MLA
Cabooter, Deirdre et al. “Kinetic Plot and Particle Size Distribution Analysis to Discuss the Performance Limits of Sub-2 Mu m and Supra-2 Mu m Particle Columns.” JOURNAL OF CHROMATOGRAPHY A 1204.1 (2008): 1–10. Print.
@article{667842,
  abstract     = {To contribute to the current debate about the {\textacutedbl}ideal{\textacutedbl} particle size range (sub-2 mu m vs. supra-2 mu m), the present study compares the kinetic performance of some commercially available sub-2 mu m and 3.5 mu m particles used under quasi-adiabatic conditions via the kinetic plot method. Under the adopted assumption that viscous heating effects can be neglected (which is uncertain in a pressure range above 400 bar), the obtained kinetic plots show that, provided each particle size is used in a column with properly optimized length, the gain in separation speed that sub-2 mu m particle columns might have over maximally performing 2.5 mu m particle columns is very small. Sub-2 mu m particle columns can only yield a gain in separation speed in the range of high-speed/low-resolution-separations (total time based on k = 10 below 5 or 10min). And even in this range, the actual gain that can be expected is only marginally small (only a few \%). The present study hence suggests that the development and the use of particles in the 2-3 mu m range should deserve more attention than it did in the past few years. However, to be competitive, this 2-3 mu m material should be packed in relatively long columns, with a packing quality matching that of the current best performing 3.5 mu m particle columns. The supra-2 mu m particles should also be able to withstand the same pressures as the sub-2 mu m particle material one is comparing it to.},
  author       = {Cabooter, Deirdre and Billen, Jeroen and Terryn, Herman and Lynen, Frederic and Sandra, Patrick and Desmet, Gert},
  issn         = {0021-9673},
  journal      = {JOURNAL OF CHROMATOGRAPHY A},
  language     = {eng},
  number       = {1},
  pages        = {1--10},
  title        = {Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns},
  url          = {http://dx.doi.org/10.1016/j.chroma.2008.07.007},
  volume       = {1204},
  year         = {2008},
}

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