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Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns

Deirdre Cabooter, Jeroen Billen, Herman Terryn, Frederic Lynen UGent, Patrick Sandra UGent and Gert Desmet (2008) JOURNAL OF CHROMATOGRAPHY A. 1204(1). p.1-10
abstract
To contribute to the current debate about the "ideal" particle size range (sub-2 mu m vs. supra-2 mu m), the present study compares the kinetic performance of some commercially available sub-2 mu m and 3.5 mu m particles used under quasi-adiabatic conditions via the kinetic plot method. Under the adopted assumption that viscous heating effects can be neglected (which is uncertain in a pressure range above 400 bar), the obtained kinetic plots show that, provided each particle size is used in a column with properly optimized length, the gain in separation speed that sub-2 mu m particle columns might have over maximally performing 2.5 mu m particle columns is very small. Sub-2 mu m particle columns can only yield a gain in separation speed in the range of high-speed/low-resolution-separations (total time based on k = 10 below 5 or 10min). And even in this range, the actual gain that can be expected is only marginally small (only a few %). The present study hence suggests that the development and the use of particles in the 2-3 mu m range should deserve more attention than it did in the past few years. However, to be competitive, this 2-3 mu m material should be packed in relatively long columns, with a packing quality matching that of the current best performing 3.5 mu m particle columns. The supra-2 mu m particles should also be able to withstand the same pressures as the sub-2 mu m particle material one is comparing it to.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
JOURNAL OF CHROMATOGRAPHY A
J. Chromatogr. A
volume
1204
issue
1
pages
1 - 10
Web of Science type
Article
Web of Science id
000259516400001
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.756 (2008)
JCR rank
6/70 (2008)
JCR quartile
1 (2008)
ISSN
0021-9673
DOI
10.1016/j.chroma.2008.07.007
language
English
UGent publication?
no
classification
A1
id
667842
handle
http://hdl.handle.net/1854/LU-667842
date created
2009-05-27 10:01:36
date last changed
2009-05-27 10:07:33
@article{667842,
  abstract     = {To contribute to the current debate about the {\textacutedbl}ideal{\textacutedbl} particle size range (sub-2 mu m vs. supra-2 mu m), the present study compares the kinetic performance of some commercially available sub-2 mu m and 3.5 mu m particles used under quasi-adiabatic conditions via the kinetic plot method. Under the adopted assumption that viscous heating effects can be neglected (which is uncertain in a pressure range above 400 bar), the obtained kinetic plots show that, provided each particle size is used in a column with properly optimized length, the gain in separation speed that sub-2 mu m particle columns might have over maximally performing 2.5 mu m particle columns is very small. Sub-2 mu m particle columns can only yield a gain in separation speed in the range of high-speed/low-resolution-separations (total time based on k = 10 below 5 or 10min). And even in this range, the actual gain that can be expected is only marginally small (only a few \%). The present study hence suggests that the development and the use of particles in the 2-3 mu m range should deserve more attention than it did in the past few years. However, to be competitive, this 2-3 mu m material should be packed in relatively long columns, with a packing quality matching that of the current best performing 3.5 mu m particle columns. The supra-2 mu m particles should also be able to withstand the same pressures as the sub-2 mu m particle material one is comparing it to.},
  author       = {Cabooter, Deirdre and Billen, Jeroen and Terryn, Herman and Lynen, Frederic and Sandra, Patrick and Desmet, Gert},
  issn         = {0021-9673},
  journal      = {JOURNAL OF CHROMATOGRAPHY A},
  language     = {eng},
  number       = {1},
  pages        = {1--10},
  title        = {Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns},
  url          = {http://dx.doi.org/10.1016/j.chroma.2008.07.007},
  volume       = {1204},
  year         = {2008},
}

Chicago
Cabooter, Deirdre, Jeroen Billen, Herman Terryn, Frederic Lynen, Patrick Sandra, and Gert Desmet. 2008. “Kinetic Plot and Particle Size Distribution Analysis to Discuss the Performance Limits of Sub-2 Mu m and Supra-2 Mu m Particle Columns.” Journal of Chromatography A 1204 (1): 1–10.
APA
Cabooter, D., Billen, J., Terryn, H., Lynen, F., Sandra, P., & Desmet, G. (2008). Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns. JOURNAL OF CHROMATOGRAPHY A, 1204(1), 1–10.
Vancouver
1.
Cabooter D, Billen J, Terryn H, Lynen F, Sandra P, Desmet G. Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 mu m and supra-2 mu m particle columns. JOURNAL OF CHROMATOGRAPHY A. 2008;1204(1):1–10.
MLA
Cabooter, Deirdre, Jeroen Billen, Herman Terryn, et al. “Kinetic Plot and Particle Size Distribution Analysis to Discuss the Performance Limits of Sub-2 Mu m and Supra-2 Mu m Particle Columns.” JOURNAL OF CHROMATOGRAPHY A 1204.1 (2008): 1–10. Print.