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Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) EXPERT REVIEW OF VACCINES. 8(4). p.499-508
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Abstract
Influenza vaccines used today are strain specific and need to be adapted every year to try and match the antigenicity of the virus strains that are predicted to cause the next epidemic. The strain specificity of the next pandemic is unpredictable. An attractive alternative approach would be to use a vaccine that matches multiple influenza virus strains, including multiple subtypes. In this review, we focus on the development and clinical potential of a vaccine that is based on the conserved ectodomain of matrix protein 2 (M2) of influenza A virus. Since 1999, a number of studies have demonstrated protection against influenza A virus challenge in animal models using chemical or genetic M2 external domain (M2e) fusion constructs. More recently, Phase I clinical studies have been conducted with M2e vaccine candidates, demonstrating their safety and immunogenicity in humans. Ultimately, and possibly in the near future, efficacy studies in humans should provide proof that this novel vaccine concept can mitigate epidemic and even pandemic influenza A virus infections.

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Chicago
Schotsaert, Michael, Marina De Filette, Walter Fiers, and Xavier Saelens. 2009. “Universal M2 Ectodomain-based Influenza A Vaccines: Preclinical and Clinical Developments.” Expert Review of Vaccines 8 (4): 499–508.
APA
Schotsaert, M., De Filette, M., Fiers, W., & Saelens, X. (2009). Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments. EXPERT REVIEW OF VACCINES, 8(4), 499–508.
Vancouver
1.
Schotsaert M, De Filette M, Fiers W, Saelens X. Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments. EXPERT REVIEW OF VACCINES. 2009;8(4):499–508.
MLA
Schotsaert, Michael et al. “Universal M2 Ectodomain-based Influenza A Vaccines: Preclinical and Clinical Developments.” EXPERT REVIEW OF VACCINES 8.4 (2009): 499–508. Print.
@article{665487,
  abstract     = {Influenza vaccines used today are strain specific and need to be adapted every year to try and match the antigenicity of the virus strains that are predicted to cause the next epidemic. The strain specificity of the next pandemic is unpredictable. An attractive alternative approach would be to use a vaccine that matches multiple influenza virus strains, including multiple subtypes. In this review, we focus on the development and clinical potential of a vaccine that is based on the conserved ectodomain of matrix protein 2 (M2) of influenza A virus. Since 1999, a number of studies have demonstrated protection against influenza A virus challenge in animal models using chemical or genetic M2 external domain (M2e) fusion constructs. More recently, Phase I clinical studies have been conducted with M2e vaccine candidates, demonstrating their safety and immunogenicity in humans. Ultimately, and possibly in the near future, efficacy studies in humans should provide proof that this novel vaccine concept can mitigate epidemic and even pandemic influenza A virus infections.},
  author       = {Schotsaert, Michael and De Filette, Marina and Fiers, Walter and Saelens, Xavier},
  issn         = {1476-0584},
  journal      = {EXPERT REVIEW OF VACCINES},
  language     = {eng},
  number       = {4},
  pages        = {499--508},
  title        = {Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments},
  url          = {http://dx.doi.org/10.1586/ERV.09.6},
  volume       = {8},
  year         = {2009},
}

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