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Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization

Lander Robays (UGent) , Tania Maes (UGent) , Guy Joos (UGent) and Karim Vermaelen (UGent)
(2009) MUCOSAL IMMUNOLOGY. 2(3). p.206-219
Author
Organization
Abstract
Exposure to cigarette smoke represents a major risk factor for the development of asthma. Enhanced sensitization toward allergens has been observed in humans and laboratory animals exposed to cigarette smoke. Pulmonary dendritic cells (DCs) are crucially involved in sensitization toward allergens and play an important role in the development of T helper (Th)2-mediated allergic airway inflammation. We propose the concept that aberrant DC activation forms the basis for the deviation of the lung's default tolerogenic response toward allergic inflammation when harmless antigens are concomittantly inhaled with tobacco smoke. This review will summarize evidence suggesting that tobacco smoke can achieve this effect by providing numerous triggers of innate immunity, which can profoundly modulate airway DC biology. Tobacco smoke can affect the airway DC network either directly or indirectly by causing the release of DC-targeted mediators from the pulmonary tissue environment, resulting in the induction of a Th2-oriented pathological immune response. A thorough knowledge of the molecular pathways involved may open the door to novel approaches in the treatment of asthma.

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Citation

Please use this url to cite or link to this publication:

MLA
Robays, Lander et al. “Between a Cough and a Wheeze: Dendritic Cells at the Nexus of Tobacco Smoke-induced Allergic Airway Sensitization.” MUCOSAL IMMUNOLOGY 2.3 (2009): 206–219. Print.
APA
Robays, L., Maes, T., Joos, G., & Vermaelen, K. (2009). Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization. MUCOSAL IMMUNOLOGY, 2(3), 206–219.
Chicago author-date
Robays, Lander, Tania Maes, Guy Joos, and Karim Vermaelen. 2009. “Between a Cough and a Wheeze: Dendritic Cells at the Nexus of Tobacco Smoke-induced Allergic Airway Sensitization.” Mucosal Immunology 2 (3): 206–219.
Chicago author-date (all authors)
Robays, Lander, Tania Maes, Guy Joos, and Karim Vermaelen. 2009. “Between a Cough and a Wheeze: Dendritic Cells at the Nexus of Tobacco Smoke-induced Allergic Airway Sensitization.” Mucosal Immunology 2 (3): 206–219.
Vancouver
1.
Robays L, Maes T, Joos G, Vermaelen K. Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization. MUCOSAL IMMUNOLOGY. 2009;2(3):206–19.
IEEE
[1]
L. Robays, T. Maes, G. Joos, and K. Vermaelen, “Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization,” MUCOSAL IMMUNOLOGY, vol. 2, no. 3, pp. 206–219, 2009.
@article{665006,
  abstract     = {Exposure to cigarette smoke represents a major risk factor for the development of asthma. Enhanced sensitization toward allergens has been observed in humans and laboratory animals exposed to cigarette smoke. Pulmonary dendritic cells (DCs) are crucially involved in sensitization toward allergens and play an important role in the development of T helper (Th)2-mediated allergic airway inflammation. We propose the concept that aberrant DC activation forms the basis for the deviation of the lung's default tolerogenic response toward allergic inflammation when harmless antigens are concomittantly inhaled with tobacco smoke. This review will summarize evidence suggesting that tobacco smoke can achieve this effect by providing numerous triggers of innate immunity, which can profoundly modulate airway DC biology. Tobacco smoke can affect the airway DC network either directly or indirectly by causing the release of DC-targeted mediators from the pulmonary tissue environment, resulting in the induction of a Th2-oriented pathological immune response. A thorough knowledge of the molecular pathways involved may open the door to novel approaches in the treatment of asthma.},
  author       = {Robays, Lander and Maes, Tania and Joos, Guy and Vermaelen, Karim},
  issn         = {1933-0219},
  journal      = {MUCOSAL IMMUNOLOGY},
  language     = {eng},
  number       = {3},
  pages        = {206--219},
  title        = {Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization},
  url          = {http://dx.doi.org/10.1038/mi.2009.7},
  volume       = {2},
  year         = {2009},
}

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