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Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal models

Tine Wyckhuys UGent, PIETER-JAN GEERTS UGent, Robrecht Raedt UGent, Kristl Vonck UGent, Wytse Wadman UGent and Paul Boon UGent (2009) ACTA NEUROLOGICA BELGICA. 109(2). p.63-80
abstract
Since the development of Deep Brain Stimulation (DBS) for Parkinson's Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TERM-FOLLOW-UP, NIGRA PARS RETICULATA, ELECTRICAL-STIMULATION, PILOCARPINE-INDUCED SEIZURES, CENTROMEDIAN THALAMIC NUCLEUS, VAGUS NERVE-STIMULATION, TEMPORAL-LOBE EPILEPSY, AMYGDALA-KINDLED SEIZURES, LOW-FREQUENCY STIMULATION, CHRONIC CEREBELLAR STIMULATION
journal title
ACTA NEUROLOGICA BELGICA
Acta Neurol. Belg.
volume
109
issue
2
pages
63 - 80
Web of Science type
Review
Web of Science id
000268312600001
JCR category
CLINICAL NEUROLOGY
JCR impact factor
0.597 (2009)
JCR rank
147/165 (2009)
JCR quartile
4 (2009)
ISSN
0300-9009
language
English
UGent publication?
yes
classification
A1
id
664720
handle
http://hdl.handle.net/1854/LU-664720
date created
2009-05-25 14:41:14
date last changed
2012-10-30 15:27:32
@article{664720,
  abstract     = {Since the development of Deep Brain Stimulation (DBS) for Parkinson's Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications.},
  author       = {Wyckhuys, Tine and GEERTS, PIETER-JAN and Raedt, Robrecht and Vonck, Kristl and Wadman, Wytse and Boon, Paul},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {TERM-FOLLOW-UP,NIGRA PARS RETICULATA,ELECTRICAL-STIMULATION,PILOCARPINE-INDUCED SEIZURES,CENTROMEDIAN THALAMIC NUCLEUS,VAGUS NERVE-STIMULATION,TEMPORAL-LOBE EPILEPSY,AMYGDALA-KINDLED SEIZURES,LOW-FREQUENCY STIMULATION,CHRONIC CEREBELLAR STIMULATION},
  language     = {eng},
  number       = {2},
  pages        = {63--80},
  title        = {Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal models},
  volume       = {109},
  year         = {2009},
}

Chicago
Wyckhuys, Tine, PIETER-JAN GEERTS, Robrecht Raedt, Kristl Vonck, Wytse Wadman, and Paul Boon. 2009. “Deep Brain Stimulation for Epilepsy: Knowledge Gained from Experimental Animal Models.” Acta Neurologica Belgica 109 (2): 63–80.
APA
Wyckhuys, T., GEERTS, P.-J., Raedt, R., Vonck, K., Wadman, W., & Boon, P. (2009). Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal models. ACTA NEUROLOGICA BELGICA, 109(2), 63–80.
Vancouver
1.
Wyckhuys T, GEERTS P-J, Raedt R, Vonck K, Wadman W, Boon P. Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal models. ACTA NEUROLOGICA BELGICA. 2009;109(2):63–80.
MLA
Wyckhuys, Tine, PIETER-JAN GEERTS, Robrecht Raedt, et al. “Deep Brain Stimulation for Epilepsy: Knowledge Gained from Experimental Animal Models.” ACTA NEUROLOGICA BELGICA 109.2 (2009): 63–80. Print.