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Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue

Isabelle De Glisezinski, Dominique Larrouy, Magda Bajzova, Katrien Koppo UGent, Jan Polak, Michel Berlan, Jens Bölow, Dominique Langin, Marie Adeline Marques and François Crampes, et al. (2009) JOURNAL OF PHYSIOLOGY-LONDON. 587(13). p.3393-3404
abstract
The relative contribution of noradrenaline (norepinephrine) and adrenaline (epinephrine) in the control of lipid mobilization in subcutaneous adipose tissue (SCAT) during exercise was evaluated in men treated with a somatostatin analogue, octreotide. Eight lean and eight obese young men matched for age and physical fitness performed 60 min exercise bouts at 50% of their maximal oxygen consumption on two occasions: (1) during i.v. infusion of octreotide, and (2) during placebo infusion. Lipolysis and local blood flow changes in SCAT were evaluated using in situ microdialysis. Infusion of octreotide suppressed plasma insulin and growth hormone levels at rest and during exercise. It blocked the exercise-induced increase in plasma adrenaline while that of noradrenaline was unchanged. Plasma natriuretic peptides (NPs) level was higher at rest and during exercise under octreotide infusion in lean men. Under placebo, no difference was found in the exercise-induced increase in glycerol between the probe perfused with Ringer solution alone and that with phentolamine (an alpha-adrenergic receptor antagonist) in lean subjects while a greater increase in glycerol was observed in the obese subjects. Under placebo, propranolol infusion in the probe containing phentolamine reduced by about 45% exercise-induced glycerol release; this effect was fully suppressed under octreotide infusion while noradrenaline was still elevated and exercise-induced lipid mobilization maintained in both lean and obese individuals. In conclusion, blockade of beta-adrenergic receptors during exercise performed during infusion of octreotide (blocking the exercise-induced rise in adrenaline but not that of noradrenaline) does not alter the exercise-induced lipolysis. This suggests that adrenaline is the main adrenergic agent contributing to exercise-induced lipolysis in SCAT. Moreover, it is the combined action of insulin suppression and NPs release which explains the lipolytic response which remains under octreotide after full local blockade of fat cell adrenergic receptors. For the moment, it is unknown if results apply specifically to SCAT and exercise only or if conclusions could be extended to all forms of lipolysis in humans.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BLOOD-FLOW, ADRENERGIC-RECEPTORS, GROWTH-HORMONE, FAT-CELL FUNCTION, BETA-ADRENOCEPTOR BLOCKADE, ATRIAL-NATRIURETIC-PEPTIDE, CATECHOLAMINE-INDUCED LIPOLYSIS, SOMATOSTATIN ANALOG, INSULIN-SECRETION, PHYSICAL EXERCISE
journal title
JOURNAL OF PHYSIOLOGY-LONDON
J. Physiol.-London
volume
587
issue
13
pages
3393 - 3404
Web of Science type
Article
Web of Science id
000267540500040
JCR category
PHYSIOLOGY
JCR impact factor
4.764 (2009)
JCR rank
6/75 (2009)
JCR quartile
1 (2009)
ISSN
0022-3751
DOI
10.1113/jphysiol.2009.168906
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
663118
handle
http://hdl.handle.net/1854/LU-663118
date created
2009-05-21 10:39:02
date last changed
2012-10-29 16:34:47
@article{663118,
  abstract     = {The relative contribution of noradrenaline (norepinephrine) and adrenaline (epinephrine) in the control of lipid mobilization in subcutaneous adipose tissue (SCAT) during exercise was evaluated in men treated with a somatostatin analogue, octreotide. Eight lean and eight obese young men matched for age and physical fitness performed 60 min exercise bouts at 50\% of their maximal oxygen consumption on two occasions: (1) during i.v. infusion of octreotide, and (2) during placebo infusion. Lipolysis and local blood flow changes in SCAT were evaluated using in situ microdialysis. Infusion of octreotide suppressed plasma insulin and growth hormone levels at rest and during exercise. It blocked the exercise-induced increase in plasma adrenaline while that of noradrenaline was unchanged. Plasma natriuretic peptides (NPs) level was higher at rest and during exercise under octreotide infusion in lean men. Under placebo, no difference was found in the exercise-induced increase in glycerol between the probe perfused with Ringer solution alone and that with phentolamine (an alpha-adrenergic receptor antagonist) in lean subjects while a greater increase in glycerol was observed in the obese subjects. Under placebo, propranolol infusion in the probe containing phentolamine reduced by about 45\% exercise-induced glycerol release; this effect was fully suppressed under octreotide infusion while noradrenaline was still elevated and exercise-induced lipid mobilization maintained in both lean and obese individuals. In conclusion, blockade of beta-adrenergic receptors during exercise performed during infusion of octreotide (blocking the exercise-induced rise in adrenaline but not that of noradrenaline) does not alter the exercise-induced lipolysis. This suggests that adrenaline is the main adrenergic agent contributing to exercise-induced lipolysis in SCAT. Moreover, it is the combined action of insulin suppression and NPs release which explains the lipolytic response which remains under octreotide after full local blockade of fat cell adrenergic receptors. For the moment, it is unknown if results apply specifically to SCAT and exercise only or if conclusions could be extended to all forms of lipolysis in humans.},
  author       = {De Glisezinski, Isabelle and Larrouy, Dominique and Bajzova, Magda and Koppo, Katrien and Polak, Jan and Berlan, Michel and B{\"o}low, Jens and Langin, Dominique and Marques, Marie Adeline and Crampes, Fran\c{c}ois and Lafontan, Max and Stich, Vladimir},
  issn         = {0022-3751},
  journal      = {JOURNAL OF PHYSIOLOGY-LONDON},
  keyword      = {BLOOD-FLOW,ADRENERGIC-RECEPTORS,GROWTH-HORMONE,FAT-CELL FUNCTION,BETA-ADRENOCEPTOR BLOCKADE,ATRIAL-NATRIURETIC-PEPTIDE,CATECHOLAMINE-INDUCED LIPOLYSIS,SOMATOSTATIN ANALOG,INSULIN-SECRETION,PHYSICAL EXERCISE},
  language     = {eng},
  number       = {13},
  pages        = {3393--3404},
  title        = {Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue},
  url          = {http://dx.doi.org/10.1113/jphysiol.2009.168906},
  volume       = {587},
  year         = {2009},
}

Chicago
De Glisezinski, Isabelle, Dominique Larrouy, Magda Bajzova, Katrien Koppo, Jan Polak, Michel Berlan, Jens Bölow, et al. 2009. “Adrenaline but Not Noradrenaline Is a Determinant of Exercise-induced Lipid Mobilization in Human Subcutaneous Adipose Tissue.” Journal of Physiology-london 587 (13): 3393–3404.
APA
De Glisezinski, I., Larrouy, D., Bajzova, M., Koppo, K., Polak, J., Berlan, M., Bölow, J., et al. (2009). Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. JOURNAL OF PHYSIOLOGY-LONDON, 587(13), 3393–3404.
Vancouver
1.
De Glisezinski I, Larrouy D, Bajzova M, Koppo K, Polak J, Berlan M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. JOURNAL OF PHYSIOLOGY-LONDON. 2009;587(13):3393–404.
MLA
De Glisezinski, Isabelle, Dominique Larrouy, Magda Bajzova, et al. “Adrenaline but Not Noradrenaline Is a Determinant of Exercise-induced Lipid Mobilization in Human Subcutaneous Adipose Tissue.” JOURNAL OF PHYSIOLOGY-LONDON 587.13 (2009): 3393–3404. Print.