Advanced search
1 file | 379.93 KB

Complement C3 and its polymorphism: biological and clinical consequences

Joris Delanghe (UGent) , Reinhart Speeckaert (UGent) and Marijn Speeckaert (UGent)
(2014) PATHOLOGY. 46(1). p.1-10
Author
Organization
Abstract
Complement 3 (C3) is a crucial component of the innate immune system, which in association with other complement proteins, forms a major host mechanism for detection and clearance of potential pathogens. The central role of the complement system and its polymorphism has already been studied extensively. Although the identification of 03 in echinoderms and tunicates suggests that this multifunctional protein emerged at least 700 million years ago, the underlying functional difference between C3S and C3F variants have not yet been clearly demonstrated. Focussing on the examined associations between C3F and C3S polymorphisms and disease states, the presence of the C3F allele has generally been linked with a detrimental outcome. In this review the general characteristics and analytical aspects of 03 and the knowledge about the biological and clinical consequences of 03 polymorphism have been summarised.
Keywords
immune system, Complement C3, polymorphism, HEMOLYTIC-UREMIC SYNDROME, DENSE DEPOSIT DISEASE, SYSTEMIC-LUPUS-ERYTHEMATOSUS, NON-HODGKIN-LYMPHOMA, 3RD COMPONENT, FACTOR-I, MACULAR DEGENERATION, FACTOR-H, MOLECULAR ANALYSIS, HAPTOGLOBIN POLYMORPHISM

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 379.93 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Delanghe, Joris, Reinhart Speeckaert, and Marijn Speeckaert. 2014. “Complement C3 and Its Polymorphism: Biological and Clinical Consequences.” Pathology 46 (1): 1–10.
APA
Delanghe, Joris, Speeckaert, R., & Speeckaert, M. (2014). Complement C3 and its polymorphism: biological and clinical consequences. PATHOLOGY, 46(1), 1–10.
Vancouver
1.
Delanghe J, Speeckaert R, Speeckaert M. Complement C3 and its polymorphism: biological and clinical consequences. PATHOLOGY. 2014;46(1):1–10.
MLA
Delanghe, Joris, Reinhart Speeckaert, and Marijn Speeckaert. “Complement C3 and Its Polymorphism: Biological and Clinical Consequences.” PATHOLOGY 46.1 (2014): 1–10. Print.
@article{6538750,
  abstract     = {Complement 3 (C3) is a crucial component of the innate immune system, which in association with other complement proteins, forms a major host mechanism for detection and clearance of potential pathogens. The central role of the complement system and its polymorphism has already been studied extensively. Although the identification of 03 in echinoderms and tunicates suggests that this multifunctional protein emerged at least 700 million years ago, the underlying functional difference between C3S and C3F variants have not yet been clearly demonstrated. Focussing on the examined associations between C3F and C3S polymorphisms and disease states, the presence of the C3F allele has generally been linked with a detrimental outcome. In this review the general characteristics and analytical aspects of 03 and the knowledge about the biological and clinical consequences of 03 polymorphism have been summarised.},
  author       = {Delanghe, Joris and Speeckaert, Reinhart and Speeckaert, Marijn},
  issn         = {0031-3025},
  journal      = {PATHOLOGY},
  keyword      = {immune system,Complement C3,polymorphism,HEMOLYTIC-UREMIC SYNDROME,DENSE DEPOSIT DISEASE,SYSTEMIC-LUPUS-ERYTHEMATOSUS,NON-HODGKIN-LYMPHOMA,3RD COMPONENT,FACTOR-I,MACULAR DEGENERATION,FACTOR-H,MOLECULAR ANALYSIS,HAPTOGLOBIN POLYMORPHISM},
  language     = {eng},
  number       = {1},
  pages        = {1--10},
  title        = {Complement C3 and its polymorphism: biological and clinical consequences},
  url          = {http://dx.doi.org/10.1097/PAT.0000000000000042},
  volume       = {46},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: