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Oocyte activation: The impact of calcium signals on fertilization

Elke Heytens UGent, Reza Soleimani UGent and Petra De Sutter UGent (2008) IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE. 6(4). p.171-174
abstract
Fertilization is triggered by changes in intracellular calcium concentration. In mammals, these transients in ooplasmic calcium concentration take the form of repetitive spikes, so called calcium oscillations (Ca2+-oscillations). These oscillations are important for relieve of meiotic arrest and to induce all the other events of oocyte activation. Although a surface mediated way of oocyte activation has been proposed, there is now substantial evidence to suggest that the sperm cell induces these Ca2+-oscillations by introducing a sperm specific phospholipase C, PLC., in the ooplasm. Ca2+-oscillations are also observed after intracytoplasmic sperm injection ( ICSI), a successful technique in human assisted reproduction. In the rare cases that no fertilization is observed following ICSI, this may be due to a deficiency in PLC.. However, artificial activating the oocytes after ICSI by increasing the calcium concentration can restore fertilization rates in these cases and support further development, as evidenced by successful pregnancies. Further evaluation of the current protocols for assisted oocyte activation is appropriate and investigation of the future application of PLC. is warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
journal title
IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE
Iran. J. Reprod. Med.
volume
6
issue
4
pages
171 - 174
Web of Science type
Review
Web of Science id
000264817400001
ISSN
1680-6433
language
English
UGent publication?
yes
classification
A1
id
624253
handle
http://hdl.handle.net/1854/LU-624253
date created
2009-05-12 10:28:20
date last changed
2009-05-15 15:07:24
@article{624253,
  abstract     = {Fertilization is triggered by changes in intracellular calcium concentration. In mammals, these transients in ooplasmic calcium concentration take the form of repetitive spikes, so called calcium oscillations (Ca2+-oscillations). These oscillations are important for relieve of meiotic arrest and to induce all the other events of oocyte activation. Although a surface mediated way of oocyte activation has been proposed, there is now substantial evidence to suggest that the sperm cell induces these Ca2+-oscillations by introducing a sperm specific phospholipase C, PLC., in the ooplasm. Ca2+-oscillations are also observed after intracytoplasmic sperm injection ( ICSI), a successful technique in human assisted reproduction. In the rare cases that no fertilization is observed following ICSI, this may be due to a deficiency in PLC.. However, artificial activating the oocytes after ICSI by increasing the calcium concentration can restore fertilization rates in these cases and support further development, as evidenced by successful pregnancies. Further evaluation of the current protocols for assisted oocyte activation is appropriate and investigation of the future application of PLC. is warranted.},
  author       = {Heytens, Elke and Soleimani, Reza and De Sutter, Petra},
  issn         = {1680-6433},
  journal      = {IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE},
  language     = {eng},
  number       = {4},
  pages        = {171--174},
  title        = {Oocyte activation: The impact of calcium signals on fertilization},
  volume       = {6},
  year         = {2008},
}

Chicago
Heytens, Elke, Reza Soleimani, and Petra De Sutter. 2008. “Oocyte Activation: The Impact of Calcium Signals on Fertilization.” Iranian Journal of Reproductive Medicine 6 (4): 171–174.
APA
Heytens, E., Soleimani, R., & De Sutter, P. (2008). Oocyte activation: The impact of calcium signals on fertilization. IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE, 6(4), 171–174.
Vancouver
1.
Heytens E, Soleimani R, De Sutter P. Oocyte activation: The impact of calcium signals on fertilization. IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE. 2008;6(4):171–4.
MLA
Heytens, Elke, Reza Soleimani, and Petra De Sutter. “Oocyte Activation: The Impact of Calcium Signals on Fertilization.” IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE 6.4 (2008): 171–174. Print.