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Development and evaluation of a continuous granulation technique using a twin-screw extruder

Barbara Van Melkebeke UGent (2009)
abstract
The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the pharmaceutical industry are to prevent segregation of the constituents of the powder mix and to improve the flow properties and compaction characteristics of the mix. The most commonly used techniques in the pharmaceutical industry for wet granulation are fluid bed granulation and high-shear granulation, which are batchwise production processes. In recent years, the development of continuous granulation processes has gained the interest in the pharmaceutical industry, due to the elimination of scale-up and the possibility of a 24h production line. Several continuous granulation processes are known, twin-screw extrusion is one of these techniques. At the Laboratory of Pharmaceutical Technology (Ghent University), a continuous twin-screw granulation process was developed by modifications to the extruder set-up and screw design, producing granules immediately suitable for tabletting. This aim of this thesis was the further development and evaluation of this continuous twin-screw granulation process.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
Process parameter, Continuous granulation, Granule quality, Twin-screw extruder, Tablet properties
pages
138 pages
publisher
Ghent University. Faculty of Pharmaceutical Sciences
place of publication
Ghent, Belgium
defense location
Gent : Farmaceutisch Instituut (auditorium I)
defense date
2009-04-27 17:00
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted materials
copyright statement
I have transferred the copyright for this publication to the publisher
id
622719
handle
http://hdl.handle.net/1854/LU-622719
alternative location
http://lib.ugent.be/fulltxt/RUG01/001/376/235/RUG01-001376235_2010_0001_AC.pdf
date created
2009-05-11 13:06:08
date last changed
2010-12-14 17:28:28
@phdthesis{622719,
  abstract     = {The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the pharmaceutical industry are to prevent segregation of the constituents of the powder mix and to improve the flow properties and compaction characteristics of the mix. The most commonly used techniques in the pharmaceutical industry for wet granulation are fluid bed granulation and high-shear granulation, which are batchwise production processes. In recent years, the development of continuous granulation processes has gained the interest in the pharmaceutical industry, due to the elimination of scale-up and the possibility of a 24h production line. Several continuous granulation processes are known, twin-screw extrusion is one of these techniques. At the Laboratory of Pharmaceutical Technology (Ghent University), a continuous twin-screw granulation process was developed by modifications to the extruder set-up and screw design, producing granules immediately suitable for tabletting.
This aim of this thesis was the further development and evaluation of this continuous twin-screw granulation process.},
  author       = {Van Melkebeke, Barbara},
  keyword      = {Process parameter,Continuous granulation,Granule quality,Twin-screw extruder,Tablet properties},
  language     = {eng},
  pages        = {138},
  publisher    = {Ghent University. Faculty of Pharmaceutical Sciences},
  school       = {Ghent University},
  title        = {Development and evaluation of a continuous granulation technique using a twin-screw extruder},
  url          = {http://lib.ugent.be/fulltxt/RUG01/001/376/235/RUG01-001376235\_2010\_0001\_AC.pdf},
  year         = {2009},
}

Chicago
Van Melkebeke, Barbara. 2009. “Development and Evaluation of a Continuous Granulation Technique Using a Twin-screw Extruder”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
APA
Van Melkebeke, B. (2009). Development and evaluation of a continuous granulation technique using a twin-screw extruder. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
Vancouver
1.
Van Melkebeke B. Development and evaluation of a continuous granulation technique using a twin-screw extruder. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2009.
MLA
Van Melkebeke, Barbara. “Development and Evaluation of a Continuous Granulation Technique Using a Twin-screw Extruder.” 2009 : n. pag. Print.