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Development and evaluation of a continuous granulation technique using a twin-screw extruder

(2009)
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Abstract
The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the pharmaceutical industry are to prevent segregation of the constituents of the powder mix and to improve the flow properties and compaction characteristics of the mix. The most commonly used techniques in the pharmaceutical industry for wet granulation are fluid bed granulation and high-shear granulation, which are batchwise production processes. In recent years, the development of continuous granulation processes has gained the interest in the pharmaceutical industry, due to the elimination of scale-up and the possibility of a 24h production line. Several continuous granulation processes are known, twin-screw extrusion is one of these techniques. At the Laboratory of Pharmaceutical Technology (Ghent University), a continuous twin-screw granulation process was developed by modifications to the extruder set-up and screw design, producing granules immediately suitable for tabletting. This aim of this thesis was the further development and evaluation of this continuous twin-screw granulation process.
Keywords
Process parameter, Continuous granulation, Granule quality, Twin-screw extruder, Tablet properties

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Citation

Please use this url to cite or link to this publication:

MLA
Van Melkebeke, Barbara. “Development and Evaluation of a Continuous Granulation Technique Using a Twin-screw Extruder.” 2009 : n. pag. Print.
APA
Van Melkebeke, B. (2009). Development and evaluation of a continuous granulation technique using a twin-screw extruder. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
Chicago author-date
Van Melkebeke, Barbara. 2009. “Development and Evaluation of a Continuous Granulation Technique Using a Twin-screw Extruder”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
Chicago author-date (all authors)
Van Melkebeke, Barbara. 2009. “Development and Evaluation of a Continuous Granulation Technique Using a Twin-screw Extruder”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
Vancouver
1.
Van Melkebeke B. Development and evaluation of a continuous granulation technique using a twin-screw extruder. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2009.
IEEE
[1]
B. Van Melkebeke, “Development and evaluation of a continuous granulation technique using a twin-screw extruder,” Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium, 2009.
@phdthesis{622719,
  abstract     = {The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the pharmaceutical industry are to prevent segregation of the constituents of the powder mix and to improve the flow properties and compaction characteristics of the mix. The most commonly used techniques in the pharmaceutical industry for wet granulation are fluid bed granulation and high-shear granulation, which are batchwise production processes. In recent years, the development of continuous granulation processes has gained the interest in the pharmaceutical industry, due to the elimination of scale-up and the possibility of a 24h production line. Several continuous granulation processes are known, twin-screw extrusion is one of these techniques. At the Laboratory of Pharmaceutical Technology (Ghent University), a continuous twin-screw granulation process was developed by modifications to the extruder set-up and screw design, producing granules immediately suitable for tabletting.
This aim of this thesis was the further development and evaluation of this continuous twin-screw granulation process.},
  author       = {Van Melkebeke, Barbara},
  keywords     = {Process parameter,Continuous granulation,Granule quality,Twin-screw extruder,Tablet properties},
  language     = {eng},
  pages        = {138},
  publisher    = {Ghent University. Faculty of Pharmaceutical Sciences},
  school       = {Ghent University},
  title        = {Development and evaluation of a continuous granulation technique using a twin-screw extruder},
  url          = {http://lib.ugent.be/fulltxt/RUG01/001/376/235/RUG01-001376235_2010_0001_AC.pdf},
  year         = {2009},
}