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Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC

Steven Van der Plas UGent, Els Van Hoeck UGent, Frederic Lynen UGent, Patrick Sandra UGent and Annemieke Madder UGent (2009) EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 11(Sp. Iss. SI). p.1796-1805
abstract
A series of human estrogen receptor (hER) mimics were synthesised. On the basis of the knowledge on the structure of the hormone binding domain of the hER, three different peptide chains were constructed onto a tripodal scaffold. By using a fully automated solid-phase synthesis protocol, 120 members with known identity were synthesised in only a week. Affinity towards estrogenic compounds was checked by affinity LC. For this purpose, ethinylestradiol was "clicked" onto a modified-silica phase, and the obtained material was packed into an HPLC column. The results stemming from the affinity LC experiments were confirmed by clicking one library member to silica and by using this solid phase to extract different endocrine-disrupting chemicals (EDCs) from aqueous media.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Eur. J. Org. Chem.
volume
11
issue
Sp. Iss. SI
pages
1796 - 1805
Web of Science type
Article
Web of Science id
000265169700018
JCR category
CHEMISTRY, ORGANIC
JCR impact factor
3.096 (2009)
JCR rank
15/57 (2009)
JCR quartile
2 (2009)
ISSN
1434-193X
DOI
10.1002/ejoc.200801290
language
English
UGent publication?
yes
classification
A1
id
611868
handle
http://hdl.handle.net/1854/LU-611868
date created
2009-05-11 08:58:33
date last changed
2009-05-11 09:03:00
@article{611868,
  abstract     = {A series of human estrogen receptor (hER) mimics were synthesised. On the basis of the knowledge on the structure of the hormone binding domain of the hER, three different peptide chains were constructed onto a tripodal scaffold. By using a fully automated solid-phase synthesis protocol, 120 members with known identity were synthesised in only a week. Affinity towards estrogenic compounds was checked by affinity LC. For this purpose, ethinylestradiol was {\textacutedbl}clicked{\textacutedbl} onto a modified-silica phase, and the obtained material was packed into an HPLC column. The results stemming from the affinity LC experiments were confirmed by clicking one library member to silica and by using this solid phase to extract different endocrine-disrupting chemicals (EDCs) from aqueous media.},
  author       = {Van der Plas, Steven and Van Hoeck, Els and Lynen, Frederic and Sandra, Patrick and Madder, Annemieke},
  issn         = {1434-193X},
  journal      = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
  language     = {eng},
  number       = {Sp. Iss. SI},
  pages        = {1796--1805},
  title        = {Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC},
  url          = {http://dx.doi.org/10.1002/ejoc.200801290},
  volume       = {11},
  year         = {2009},
}

Chicago
Van der Plas, Steven, Els Van Hoeck, Frederic Lynen, Patrick Sandra, and Annemieke Madder. 2009. “Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC.” European Journal of Organic Chemistry 11 (Sp. Iss. SI): 1796–1805.
APA
Van der Plas, S., Van Hoeck, E., Lynen, F., Sandra, P., & Madder, A. (2009). Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 11(Sp. Iss. SI), 1796–1805.
Vancouver
1.
Van der Plas S, Van Hoeck E, Lynen F, Sandra P, Madder A. Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2009;11(Sp. Iss. SI):1796–805.
MLA
Van der Plas, Steven, Els Van Hoeck, Frederic Lynen, et al. “Towards a New SPE Material for EDCs: Fully Automated Synthesis of a Library of Tripodal Receptors Followed by Fast Screening by Affinity LC.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 11.Sp. Iss. SI (2009): 1796–1805. Print.