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Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat

Robrecht Raedt UGent, Annelies Van Dycke UGent, D. Van Melkebeke, Tim De Smedt, P. Claeys, Tine Wyckhuys UGent, Kristl Vonck UGent, Wytse Wadman UGent and Paul Boon UGent (2009) Acta Neurologica Scandinavica. 119(5). p.293-303
abstract
Intrahippocampal injection of kainic acid (KA) in rats evokes a status epilepticus (SE) and leads to spontaneous seizures. However to date, precise electroencephalographic (EEG) and clinical characterization of spontaneous seizures in this epilepsy model using long-term video-EEG monitoring has not been performed. Rats were implanted with bipolar hippocampal depth electrodes and a cannula for the injection of KA (0.4 mu g/0.2 mu l) in the right hippocampus. Video-EEG monitoring was used to determine habitual parameters of spontaneous seizures such as seizure frequency, severity, progression and day-night rhythms. Spontaneous seizures were detected in all rats with 13 out of 15 animals displaying seizures during the first eight weeks after SE. A considerable fraction (35%) of the spontaneous seizures did not generalize secondarily. Seizure frequency was quite variable and the majority of the KA-treated animals had less than one seizure per day. A circadian rhythm was observed in all rats that showed sufficient seizures per day. This study shows that the characteristics of spontaneous seizures in the intrahippocampal KA model display many similarities to other SE models and human temporal lobe epilepsy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
kainic acid, video-EEG monitoring, seizures, intrahippocampal, status epilepticus, temporal lobe epilepsy, characterization
journal title
Acta Neurologica Scandinavica
Acta Neurol. Scand.
volume
119
issue
5
pages
293 - 303
publisher
Wiley-Blackwell Publishing Inc
place of publication
Malden MA USA
Web of Science type
Article
Web of Science id
000265069900002
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.324 (2009)
JCR rank
78/165 (2009)
JCR quartile
2 (2009)
ISSN
0001-6314
DOI
10.1111/j.1600-0404.2008.01108.x
language
English
UGent publication?
yes
classification
A1
id
610893
handle
http://hdl.handle.net/1854/LU-610893
date created
2009-05-08 14:31:10
date last changed
2009-05-28 11:12:42
@article{610893,
  abstract     = {Intrahippocampal injection of kainic acid (KA) in rats evokes a status epilepticus (SE) and leads to spontaneous seizures. However to date, precise electroencephalographic (EEG) and clinical characterization of spontaneous seizures in this epilepsy model using long-term video-EEG monitoring has not been performed.
Rats were implanted with bipolar hippocampal depth electrodes and a cannula for the injection of KA (0.4 mu g/0.2 mu l) in the right hippocampus. Video-EEG monitoring was used to determine habitual parameters of spontaneous seizures such as seizure frequency, severity, progression and day-night rhythms.

Spontaneous seizures were detected in all rats with 13 out of 15 animals displaying seizures during the first eight weeks after SE. A considerable fraction (35\%) of the spontaneous seizures did not generalize secondarily. Seizure frequency was quite variable and the majority of the KA-treated animals had less than one seizure per day. A circadian rhythm was observed in all rats that showed sufficient seizures per day.

This study shows that the characteristics of spontaneous seizures in the intrahippocampal KA model display many similarities to other SE models and human temporal lobe epilepsy.},
  author       = {Raedt, Robrecht and Van Dycke, Annelies and Van Melkebeke, D. and De Smedt, Tim and Claeys, P. and Wyckhuys, Tine and Vonck, Kristl and Wadman, Wytse and Boon, Paul},
  issn         = {0001-6314},
  journal      = {Acta Neurologica Scandinavica},
  keyword      = {kainic acid,video-EEG monitoring,seizures,intrahippocampal,status epilepticus,temporal lobe epilepsy,characterization},
  language     = {eng},
  number       = {5},
  pages        = {293--303},
  publisher    = {Wiley-Blackwell Publishing Inc},
  title        = {Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2008.01108.x},
  volume       = {119},
  year         = {2009},
}

Chicago
Raedt, Robrecht, ANNELIES VAN DYCKE, D. Van Melkebeke, Tim De Smedt, P. Claeys, Tine Wyckhuys, Kristl Vonck, Wytse Wadman, and Paul Boon. 2009. “Seizures in the Intrahippocampal Kainic Acid Epilepsy Model: Characterization Using Long-term video-EEG Monitoring in the Rat.” Acta Neurologica Scandinavica 119 (5): 293–303.
APA
Raedt, Robrecht, VAN DYCKE, A., Van Melkebeke, D., De Smedt, T., Claeys, P., Wyckhuys, T., Vonck, K., et al. (2009). Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat. Acta Neurologica Scandinavica, 119(5), 293–303.
Vancouver
1.
Raedt R, VAN DYCKE A, Van Melkebeke D, De Smedt T, Claeys P, Wyckhuys T, et al. Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat. Acta Neurologica Scandinavica. Malden MA USA: Wiley-Blackwell Publishing Inc; 2009;119(5):293–303.
MLA
Raedt, Robrecht, ANNELIES VAN DYCKE, D. Van Melkebeke, et al. “Seizures in the Intrahippocampal Kainic Acid Epilepsy Model: Characterization Using Long-term video-EEG Monitoring in the Rat.” Acta Neurologica Scandinavica 119.5 (2009): 293–303. Print.