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Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery

Nele Poelvoorde (UGent)
(2009)
Author
Promoter
(UGent) and (UGent)
Organization
Abstract
The aim of this research project was to develop multi-particulate dosage forms for delivery of lactic acid bacteria: (a) the development of an oral dosage form containing a high concentration of viable, genetically modified, IL-10 producing Lactococcus lactis (b) the development of a formulation for delivery of health-promoting strains of lactic acid bacteria (referred to as probiotics) to the vagina. In addition to the viability of the lactobacilli strains incorporated in the formulation the vaginal retention time and spreading of the formulation in the vaginal cavity are essential quality parameters of this vaginal formulation. Chapter 1 reviews the use of genetically modified Lactococcus lactis and probiotic Lactobacillus strains as therapeutics in the treatment of Crohn’s disease and bacterial vaginosis, respectively. The strategies used to stabilise lactic acid bacteria in solid dosage forms and the processing techniques used to manufacture the oral and vaginal dosage forms are also discussed in this introductory chapter.
Keywords
skim milk: COATING POLYMERS, CROHNS-DISEASE, lactose, Eudragit, pellets, ileum targeting, recombinant Lactococcus lactis, layering, viability, BACTERIA, SURVIVAL, INTERLEUKIN-10

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Citation

Please use this url to cite or link to this publication:

MLA
Poelvoorde, Nele. “Development of a Multi-particulate Formulation of Viable Bacteria for Oral and Vaginal Delivery.” 2009 : n. pag. Print.
APA
Poelvoorde, N. (2009). Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery. Gent.
Chicago author-date
Poelvoorde, Nele. 2009. “Development of a Multi-particulate Formulation of Viable Bacteria for Oral and Vaginal Delivery”. Gent.
Chicago author-date (all authors)
Poelvoorde, Nele. 2009. “Development of a Multi-particulate Formulation of Viable Bacteria for Oral and Vaginal Delivery”. Gent.
Vancouver
1.
Poelvoorde N. Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery. [Gent]; 2009.
IEEE
[1]
N. Poelvoorde, “Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery,” Gent, 2009.
@phdthesis{610271,
  abstract     = {The aim of this research project was to develop multi-particulate dosage forms for delivery of lactic acid bacteria: (a) the development of an oral dosage form containing a high concentration of viable, genetically modified, IL-10 producing Lactococcus lactis (b) the development of a formulation for delivery of health-promoting strains of lactic acid bacteria (referred to as probiotics) to the vagina. In addition to the viability of the lactobacilli strains incorporated in the formulation the vaginal retention time and spreading of the formulation in the vaginal cavity are essential quality parameters of this vaginal formulation. Chapter 1 reviews the use of genetically modified Lactococcus lactis and probiotic Lactobacillus strains as therapeutics in the treatment of Crohn’s disease and bacterial vaginosis, respectively. The strategies used to stabilise lactic acid bacteria in solid dosage forms and the processing techniques used to manufacture the oral and vaginal dosage forms are also discussed in this introductory chapter.},
  author       = {Poelvoorde, Nele},
  keywords     = {skim milk: COATING POLYMERS,CROHNS-DISEASE,lactose,Eudragit,pellets,ileum targeting,recombinant Lactococcus lactis,layering,viability,BACTERIA,SURVIVAL,INTERLEUKIN-10},
  language     = {eng},
  pages        = {160},
  school       = {Ghent University},
  title        = {Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery},
  url          = {http://lib.ugent.be/fulltxt/RUG01/001/334/703/RUG01-001334703_2010_0001_AC.pdf},
  year         = {2009},
}