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A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy

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Abstract
Objectives: At Ghent University Hospital, the feasibility and efficacy of the modified Atkins' diet was evaluated in adult patients with refractory epilepsy. The Atkins' diet restricts carbohydrate intake and was originally designed for weight loss. Patients and methods: During a 6-month trial period, a carbohydrate restriction of 20 g/day was in place. During a 36 h hospital admission, patients were instructed about the diet. Patients underwent clinical neurological testing, EEG, ECG, blood and urine analyses and mood evaluation before and during the trial. Seizure frequency and side effects were recorded in seizure diaries and followed up at monthly clinic visits. Results: Eight patients were included in the study. Three out of eight patients followed the diet for 6 months. One out of three patients showed a >50% seizure reduction, 1/3 > 30%, and 1/3 < 30%. Side effects such as constipation and diarrhoea were mild and occurred mainly during, the initial week of the diet. Patients reported improved concentration and well being. This was confirmed by improved scores on the Beck Depression Inventory Scale. Conclusion: This pilot Study shows that the modified Atkins' diet is feasible in an adult population, and that seizure frequency reduction is possible. The results need to be confirmed in larger prospective, controlled studies with comparison groups.
Keywords
ketogenic, refractory epilepsy, modified Atkins' diet, adults

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Chicago
Carrette, Evelien, Kristl Vonck, Veerle De Herdt, Isabelle Dewaele, Robrecht Raedt, Lutgart Goossens, Michel Van Zandijcke, Wytse Wadman, Vijay Thadani, and Paul Boon. 2008. “A Pilot Trial with Modified Atkins’ Diet in Adult Patients with Refractory Epilepsy.” Clinical Neurology and Neurosurgery 110 (8): 797–803.
APA
Carrette, E., Vonck, K., De Herdt, V., Dewaele, I., Raedt, R., Goossens, L., Van Zandijcke, M., et al. (2008). A pilot trial with modified Atkins’ diet in adult patients with refractory epilepsy. Clinical Neurology and Neurosurgery, 110(8), 797–803.
Vancouver
1.
Carrette E, Vonck K, De Herdt V, Dewaele I, Raedt R, Goossens L, et al. A pilot trial with modified Atkins’ diet in adult patients with refractory epilepsy. Clinical Neurology and Neurosurgery. 2008;110(8):797–803.
MLA
Carrette, Evelien, Kristl Vonck, Veerle De Herdt, et al. “A Pilot Trial with Modified Atkins’ Diet in Adult Patients with Refractory Epilepsy.” Clinical Neurology and Neurosurgery 110.8 (2008): 797–803. Print.
@article{609972,
  abstract     = {Objectives: At Ghent University Hospital, the feasibility and efficacy of the modified Atkins' diet was evaluated in adult patients with refractory epilepsy. The Atkins' diet restricts carbohydrate intake and was originally designed for weight loss.
Patients and methods: During a 6-month trial period, a carbohydrate restriction of 20 g/day was in place. During a 36 h hospital admission, patients were instructed about the diet. Patients underwent clinical neurological testing, EEG, ECG, blood and urine analyses and mood evaluation before and during the trial. Seizure frequency and side effects were recorded in seizure diaries and followed up at monthly clinic visits.

Results: Eight patients were included in the study. Three out of eight patients followed the diet for 6 months. One out of three patients showed a {\textrangle}50\% seizure reduction, 1/3 {\textrangle} 30\%, and 1/3 {\textlangle} 30\%. Side effects such as constipation and diarrhoea were mild and occurred mainly during, the initial week of the diet. Patients reported improved concentration and well being. This was confirmed by improved scores on the Beck Depression Inventory Scale.

Conclusion: This pilot Study shows that the modified Atkins' diet is feasible in an adult population, and that seizure frequency reduction is possible. The results need to be confirmed in larger prospective, controlled studies with comparison groups.},
  author       = {Carrette, Evelien and Vonck, Kristl and De Herdt, Veerle and Dewaele, Isabelle and Raedt, Robrecht and Goossens, Lutgart and Van Zandijcke, Michel and Wadman, Wytse and Thadani, Vijay and Boon, Paul},
  issn         = {0303-8467},
  journal      = {Clinical Neurology and Neurosurgery},
  keyword      = {ketogenic,refractory epilepsy,modified Atkins' diet,adults},
  language     = {eng},
  number       = {8},
  pages        = {797--803},
  title        = {A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy},
  url          = {http://dx.doi.org/10.1016/j.clineuro.2008.05.003},
  volume       = {110},
  year         = {2008},
}

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