Ghent University Academic Bibliography

Advanced

Extracellular barriers in respiratory gene therapy

Niek Sanders UGent, Carsten Rudolph, Kevin Braeckmans UGent, Stefaan De Smedt UGent and Jo Demeester UGent (2009) Advanced Drug Delivery Reviews. 61(2). p.115-127
abstract
Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid. This must allow the reader to gain insights into the mechanisms by which respiratory secretions may impede the gene transfer efficiency of nucleic acid containing nanoparticles (NANs). Subsequently, we will summarize the efforts that have been done to understand the barrier properties of respiratory mucus and alveolar fluid towards the respiratory delivery of therapeutic nucleic acids. Finally, new and current strategies that can overcome the inhibitory effects of respiratory secretions are discussed. (C) 2008 Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Respiratory gene therapy, DNA DELIVERY, NANs, Nucleic acid containing nanoparticles, Mucus Alveolar fluid, CYSTIC-FIBROSIS SPUTUM, BRONCHOALVEOLAR LAVAGE FLUID, POLYMER-COATED ADENOVIRUS, IN-VITRO, PULMONARY SURFACTANT, AIRWAY EPITHELIUM, MUCOLYTIC AGENTS, MAGNETIC FORCE, MUC5B MUCINS
journal title
Advanced Drug Delivery Reviews
Adv. Drug Deliv. Rev.
volume
61
issue
2
pages
115 - 127
Web of Science type
Review
Web of Science id
000264451100005
ISSN
016-409X
DOI
10.1016/j.addr.2008.09.011
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
604030
handle
http://hdl.handle.net/1854/LU-604030
date created
2009-04-29 16:11:03
date last changed
2009-05-04 09:36:23
@article{604030,
  abstract     = {Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid. This must allow the reader to gain insights into the mechanisms by which respiratory secretions may impede the gene transfer efficiency of nucleic acid containing nanoparticles (NANs). Subsequently, we will summarize the efforts that have been done to understand the barrier properties of respiratory mucus and alveolar fluid towards the respiratory delivery of therapeutic nucleic acids. Finally, new and current strategies that can overcome the inhibitory effects of respiratory secretions are discussed. (C) 2008 Elsevier B.V. All rights reserved.},
  author       = {Sanders, Niek and Rudolph, Carsten and Braeckmans, Kevin and De Smedt, Stefaan and Demeester, Jo},
  issn         = {016-409X},
  journal      = {Advanced Drug Delivery Reviews},
  keyword      = {Respiratory gene therapy,DNA DELIVERY,NANs,Nucleic acid containing nanoparticles,Mucus Alveolar fluid,CYSTIC-FIBROSIS SPUTUM,BRONCHOALVEOLAR LAVAGE FLUID,POLYMER-COATED ADENOVIRUS,IN-VITRO,PULMONARY SURFACTANT,AIRWAY EPITHELIUM,MUCOLYTIC AGENTS,MAGNETIC FORCE,MUC5B MUCINS},
  language     = {eng},
  number       = {2},
  pages        = {115--127},
  title        = {Extracellular barriers in respiratory gene therapy},
  url          = {http://dx.doi.org/10.1016/j.addr.2008.09.011},
  volume       = {61},
  year         = {2009},
}

Chicago
Sanders, Niek, Carsten Rudolph, Kevin Braeckmans, Stefaan De Smedt, and Jo Demeester. 2009. “Extracellular Barriers in Respiratory Gene Therapy.” Advanced Drug Delivery Reviews 61 (2): 115–127.
APA
Sanders, N., Rudolph, C., Braeckmans, K., De Smedt, S., & Demeester, J. (2009). Extracellular barriers in respiratory gene therapy. Advanced Drug Delivery Reviews, 61(2), 115–127.
Vancouver
1.
Sanders N, Rudolph C, Braeckmans K, De Smedt S, Demeester J. Extracellular barriers in respiratory gene therapy. Advanced Drug Delivery Reviews. 2009;61(2):115–27.
MLA
Sanders, Niek, Carsten Rudolph, Kevin Braeckmans, et al. “Extracellular Barriers in Respiratory Gene Therapy.” Advanced Drug Delivery Reviews 61.2 (2009): 115–127. Print.