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Recommendations for the treatment of epilepsies in general practice in Belgium

Paul Boon UGent, Sebastiaan Engelborghs, Henri Hauman, An Jansen, Lieven Lagae, Benjamin Legros, Michel Ossemann, Bernard Sadzot, Etienne Urbain and Kenou van Rijckevorsel (2008) Acta Neurologica Belgica. 108(4). p.118-130
abstract
The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guidelines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients (>= 16 years) and initial monotherapy in paediatric patients (< 16 years). For these three situations a first choice AED is recommended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008. In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
LEVETIRACETAM, THERAPEUTICS, EFFICACY, CARBAMAZEPINE, AMERICAN ACADEMY, EPILEPTIC SEIZURES, ANTIEPILEPTIC DRUGS, RANDOMIZED CONTROLLED-TRIAL, TECHNOLOGY-ASSESSMENT SUBCOMMITTEE, QUALITY STANDARDS SUBCOMMITTEE
journal title
Acta Neurologica Belgica
Acta Neurol. Belg.
volume
108
issue
4
pages
118 - 130
publisher
Acta Medica Belgica
place of publication
Brussels, Belgium
Web of Science type
Article
Web of Science id
000263358900002
JCR category
CLINICAL NEUROLOGY
JCR impact factor
0.77 (2008)
JCR rank
140/156 (2008)
JCR quartile
4 (2008)
ISSN
0300-9009
language
English
UGent publication?
yes
classification
A1
id
603121
handle
http://hdl.handle.net/1854/LU-603121
date created
2009-04-28 16:39:01
date last changed
2009-05-04 14:11:14
@article{603121,
  abstract     = {The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guidelines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients ({\textrangle}= 16 years) and initial monotherapy in paediatric patients ({\textlangle} 16 years). For these three situations a first choice AED is recommended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008.
In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution.},
  author       = {Boon, Paul and Engelborghs, Sebastiaan and Hauman, Henri and Jansen, An and Lagae, Lieven and Legros, Benjamin and Ossemann, Michel and Sadzot, Bernard and Urbain, Etienne and van Rijckevorsel, Kenou},
  issn         = {0300-9009},
  journal      = {Acta Neurologica Belgica},
  keyword      = {LEVETIRACETAM,THERAPEUTICS,EFFICACY,CARBAMAZEPINE,AMERICAN ACADEMY,EPILEPTIC SEIZURES,ANTIEPILEPTIC DRUGS,RANDOMIZED CONTROLLED-TRIAL,TECHNOLOGY-ASSESSMENT SUBCOMMITTEE,QUALITY STANDARDS SUBCOMMITTEE},
  language     = {eng},
  number       = {4},
  pages        = {118--130},
  publisher    = {Acta Medica Belgica},
  title        = {Recommendations for the treatment of epilepsies in general practice in Belgium},
  volume       = {108},
  year         = {2008},
}

Chicago
Boon, Paul, Sebastiaan Engelborghs, Henri Hauman, An Jansen, Lieven Lagae, Benjamin Legros, Michel Ossemann, Bernard Sadzot, Etienne Urbain, and Kenou van Rijckevorsel. 2008. “Recommendations for the Treatment of Epilepsies in General Practice in Belgium.” Acta Neurologica Belgica 108 (4): 118–130.
APA
Boon, P., Engelborghs, S., Hauman, H., Jansen, A., Lagae, L., Legros, B., Ossemann, M., et al. (2008). Recommendations for the treatment of epilepsies in general practice in Belgium. Acta Neurologica Belgica, 108(4), 118–130.
Vancouver
1.
Boon P, Engelborghs S, Hauman H, Jansen A, Lagae L, Legros B, et al. Recommendations for the treatment of epilepsies in general practice in Belgium. Acta Neurologica Belgica. Brussels, Belgium: Acta Medica Belgica; 2008;108(4):118–30.
MLA
Boon, Paul, Sebastiaan Engelborghs, Henri Hauman, et al. “Recommendations for the Treatment of Epilepsies in General Practice in Belgium.” Acta Neurologica Belgica 108.4 (2008): 118–130. Print.