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Role of coagulase-negative staphylococci in human disease

Anne Piette UGent and GERDA VERSCHRAEGEN UGent (2009) VETERINARY MICROBIOLOGY. 134(1-2). p.54-54
abstract
Coagulase-negative staphylococci (CNS) are normal inhabitants of human skin and mucous membranes. They have long been dismissed as culture contaminants, but now the potentially important role of CNS as pathogens and their increasing incidence has been recognized. Approximately 55-75% of nosocomial isolates is methicillin resistant. CNS were the first organisms in which glycopeptide resistance was recognized. In the immunocompetent host, CNS endocarditis and urinary tract infections with Staphylococcus saprophyticus are the most common CNS infections. Other patients are usually immunocompromised, with indwelling or implanted foreign bodies. CNS account for approximately 30% of all nosocomial blood stream infections. The majority of these concern catheter-related sepsis. Other important infections due to CNS include central nervous system shunt infections, endophthalmitis, surgical site infections, peritonitis in patients with continuous ambulatory peritoneal dialysis and foreign body infections. CNS are rarely associated with mastitis in humans. Staphylococcus lugdunensis is more pathogenic than other CNS as it expresses several potential virulence factors. The distinction between clinically significant, pathogenic and contaminating isolates is a major problem. Several studies show clonal intra and inter hospital spread of Staphylococcus epidermidis strains which suggests that infection control measures may be necessary for multiresistant CNS isolates as for methicillin resistant Staphylococcus aureus. As a result of medical progress, mainly due to the use of invasive and indwelling medical devices, CNS are now a major cause of nosocomial and health-care related infections. (C) 2008 Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Antibiotic resistance, Species distribution, Endocarditis, Urinary tract infections, Blood stream infections, Nosocomial infection, URINARY-TRACT-INFECTIONS, BLOOD-STREAM INFECTIONS, AMBULATORY PERITONEAL-DIALYSIS, ANTIMICROBIAL SUSCEPTIBILITY, CATHETER-RELATED INFECTIONS, INTENSIVE-CARE-UNIT, MOLECULAR EPIDEMIOLOGY, SPECIES DISTRIBUTION, NOSOCOMIAL INFECTIONS, Human medicine, Coagulase-negative staphylococci, EPIDERMIDIS STRAINS
journal title
VETERINARY MICROBIOLOGY
Vet. Microbiol.
volume
134
issue
1-2
pages
54 - 54
Web of Science type
Article
Web of Science id
000263421900008
JCR category
VETERINARY SCIENCES
JCR impact factor
2.874 (2009)
JCR rank
4/141 (2009)
JCR quartile
1 (2009)
ISSN
0378-1135
DOI
10.1016/j.vetmic.2008.09.009
language
English
UGent publication?
yes
classification
A1
id
601744
handle
http://hdl.handle.net/1854/LU-601744
date created
2009-04-27 16:13:39
date last changed
2009-04-29 10:12:35
@article{601744,
  abstract     = {Coagulase-negative staphylococci (CNS) are normal inhabitants of human skin and mucous membranes. They have long been dismissed as culture contaminants, but now the potentially important role of CNS as pathogens and their increasing incidence has been recognized. Approximately 55-75\% of nosocomial isolates is methicillin resistant. CNS were the first organisms in which glycopeptide resistance was recognized. In the immunocompetent host, CNS endocarditis and urinary tract infections with Staphylococcus saprophyticus are the most common CNS infections. Other patients are usually immunocompromised, with indwelling or implanted foreign bodies. CNS account for approximately 30\% of all nosocomial blood stream infections. The majority of these concern catheter-related sepsis. Other important infections due to CNS include central nervous system shunt infections, endophthalmitis, surgical site infections, peritonitis in patients with continuous ambulatory peritoneal dialysis and foreign body infections. CNS are rarely associated with mastitis in humans. Staphylococcus lugdunensis is more pathogenic than other CNS as it expresses several potential virulence factors. The distinction between clinically significant, pathogenic and contaminating isolates is a major problem. Several studies show clonal intra and inter hospital spread of Staphylococcus epidermidis strains which suggests that infection control measures may be necessary for multiresistant CNS isolates as for methicillin resistant Staphylococcus aureus. As a result of medical progress, mainly due to the use of invasive and indwelling medical devices, CNS are now a major cause of nosocomial and health-care related infections. (C) 2008 Elsevier B.V. All rights reserved.},
  author       = {Piette, Anne and VERSCHRAEGEN, GERDA},
  issn         = {0378-1135},
  journal      = {VETERINARY MICROBIOLOGY},
  keyword      = {Antibiotic resistance,Species distribution,Endocarditis,Urinary tract infections,Blood stream infections,Nosocomial infection,URINARY-TRACT-INFECTIONS,BLOOD-STREAM INFECTIONS,AMBULATORY PERITONEAL-DIALYSIS,ANTIMICROBIAL SUSCEPTIBILITY,CATHETER-RELATED INFECTIONS,INTENSIVE-CARE-UNIT,MOLECULAR EPIDEMIOLOGY,SPECIES DISTRIBUTION,NOSOCOMIAL INFECTIONS,Human medicine,Coagulase-negative staphylococci,EPIDERMIDIS STRAINS},
  language     = {eng},
  number       = {1-2},
  pages        = {54--54},
  title        = {Role of coagulase-negative staphylococci in human disease},
  url          = {http://dx.doi.org/10.1016/j.vetmic.2008.09.009},
  volume       = {134},
  year         = {2009},
}

Chicago
Piette, Anne, and GERDA VERSCHRAEGEN. 2009. “Role of Coagulase-negative Staphylococci in Human Disease.” Veterinary Microbiology 134 (1-2): 54–54.
APA
Piette, A., & VERSCHRAEGEN, G. (2009). Role of coagulase-negative staphylococci in human disease. VETERINARY MICROBIOLOGY, 134(1-2), 54–54.
Vancouver
1.
Piette A, VERSCHRAEGEN G. Role of coagulase-negative staphylococci in human disease. VETERINARY MICROBIOLOGY. 2009;134(1-2):54–54.
MLA
Piette, Anne, and GERDA VERSCHRAEGEN. “Role of Coagulase-negative Staphylococci in Human Disease.” VETERINARY MICROBIOLOGY 134.1-2 (2009): 54–54. Print.