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Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort

Liesbet Van Praet, Lennart Jans (UGent) , Philippe Carron (UGent) , Peggy Jacques (UGent) , Elien Glorieus (UGent) , Roos Colman (UGent) , Heleen Cypers (UGent) , Herman Mielants (UGent) , Martine De Vos (UGent) , Claude Cuvelier (UGent) , et al.
(2014) ANNALS OF THE RHEUMATIC DISEASES. 73(6). p.1186-1189
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Abstract
Introduction: Bone marrow oedema (BMO) of the sacroiliac joints (SIJs) is a hallmark of axial spondyloarthritis (SpA). However, the relationship between the extent of BMO and disease phenotype is poorly understood. Objective: To assess the link between BMO of the SIJs and gut inflammation. We have also evaluated the correlation between BMO and established disease activity parameters. Methods: Sixty-eight patients with axial SpA from the Gent Inflammatory Arthritis and spoNdylitis cohorT underwent ileocolonoscopy and MRI of the SIJs. Histopathological analysis and SPondyloArthritis Research Consortium of Canada (SPARCC) scores were performed. Results: A significant higher SPARCC score (median (range)) was observed in axial SpA patients showing chronic gut inflammation (16.9 (3.8-68.3)) compared with axial SpA patients showing normal gut histology (9.8 (0.0-45.0); p<0.05). In a multiple linear regression model, we identified, besides chronic gut inflammation (effect size of 11.3, 95% CI (2.1 to 20.4)), male sex (effect size of 10.5, 95% CI (3.3 to 17.8)) to be independently associated to the extent of BMO. There was a low to moderate correlation between the degree of BMO and C-reactive protein(r=0.39, p=0.002) and Ankylosing Spondylitis Disease Activity Score (r=0.35, p=0.007). Conclusions: Higher degrees of BMO were observed in patients showing chronic gut inflammation. These data solidify a link between mucosal inflammation and progressive disease in axial SpA.
Keywords
CLASSIFICATION CRITERIA, SPONDYLARTHROPATHY, DISEASE-ACTIVITY, ANKYLOSING-SPONDYLITIS, SPINAL INFLAMMATION, ABNORMALITIES, EVOLUTION, HISTOLOGY

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MLA
Van Praet, Liesbet, et al. “Degree of Bone Marrow Oedema in Sacroiliac Joints of Patients with Axial Spondyloarthritis Is Linked to Gut Inflammation and Male Sex: Results from the GIANT Cohort.” ANNALS OF THE RHEUMATIC DISEASES, vol. 73, no. 6, 2014, pp. 1186–89, doi:10.1136/annrheumdis-2013-203854.
APA
Van Praet, L., Jans, L., Carron, P., Jacques, P., Glorieus, E., Colman, R., … Elewaut, D. (2014). Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. ANNALS OF THE RHEUMATIC DISEASES, 73(6), 1186–1189. https://doi.org/10.1136/annrheumdis-2013-203854
Chicago author-date
Van Praet, Liesbet, Lennart Jans, Philippe Carron, Peggy Jacques, Elien Glorieus, Roos Colman, Heleen Cypers, et al. 2014. “Degree of Bone Marrow Oedema in Sacroiliac Joints of Patients with Axial Spondyloarthritis Is Linked to Gut Inflammation and Male Sex: Results from the GIANT Cohort.” ANNALS OF THE RHEUMATIC DISEASES 73 (6): 1186–89. https://doi.org/10.1136/annrheumdis-2013-203854.
Chicago author-date (all authors)
Van Praet, Liesbet, Lennart Jans, Philippe Carron, Peggy Jacques, Elien Glorieus, Roos Colman, Heleen Cypers, Herman Mielants, Martine De Vos, Claude Cuvelier, Filip Van den Bosch, and Dirk Elewaut. 2014. “Degree of Bone Marrow Oedema in Sacroiliac Joints of Patients with Axial Spondyloarthritis Is Linked to Gut Inflammation and Male Sex: Results from the GIANT Cohort.” ANNALS OF THE RHEUMATIC DISEASES 73 (6): 1186–1189. doi:10.1136/annrheumdis-2013-203854.
Vancouver
1.
Van Praet L, Jans L, Carron P, Jacques P, Glorieus E, Colman R, et al. Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. ANNALS OF THE RHEUMATIC DISEASES. 2014;73(6):1186–9.
IEEE
[1]
L. Van Praet et al., “Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort,” ANNALS OF THE RHEUMATIC DISEASES, vol. 73, no. 6, pp. 1186–1189, 2014.
@article{5985192,
  abstract     = {{Introduction: Bone marrow oedema (BMO) of the sacroiliac joints (SIJs) is a hallmark of axial spondyloarthritis (SpA). However, the relationship between the extent of BMO and disease phenotype is poorly understood. 
Objective: To assess the link between BMO of the SIJs and gut inflammation. We have also evaluated the correlation between BMO and established disease activity parameters. 
Methods: Sixty-eight patients with axial SpA from the Gent Inflammatory Arthritis and spoNdylitis cohorT underwent ileocolonoscopy and MRI of the SIJs. Histopathological analysis and SPondyloArthritis Research Consortium of Canada (SPARCC) scores were performed. 
Results: A significant higher SPARCC score (median (range)) was observed in axial SpA patients showing chronic gut inflammation (16.9 (3.8-68.3)) compared with axial SpA patients showing normal gut histology (9.8 (0.0-45.0); p<0.05). In a multiple linear regression model, we identified, besides chronic gut inflammation (effect size of 11.3, 95% CI (2.1 to 20.4)), male sex (effect size of 10.5, 95% CI (3.3 to 17.8)) to be independently associated to the extent of BMO. There was a low to moderate correlation between the degree of BMO and C-reactive protein(r=0.39, p=0.002) and Ankylosing Spondylitis Disease Activity Score (r=0.35, p=0.007). 
Conclusions: Higher degrees of BMO were observed in patients showing chronic gut inflammation. These data solidify a link between mucosal inflammation and progressive disease in axial SpA.}},
  author       = {{Van Praet, Liesbet and Jans, Lennart and Carron, Philippe and Jacques, Peggy and Glorieus, Elien and Colman, Roos and Cypers, Heleen and Mielants, Herman and De Vos, Martine and Cuvelier, Claude and Van den Bosch, Filip and Elewaut, Dirk}},
  issn         = {{0003-4967}},
  journal      = {{ANNALS OF THE RHEUMATIC DISEASES}},
  keywords     = {{CLASSIFICATION CRITERIA,SPONDYLARTHROPATHY,DISEASE-ACTIVITY,ANKYLOSING-SPONDYLITIS,SPINAL INFLAMMATION,ABNORMALITIES,EVOLUTION,HISTOLOGY}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1186--1189}},
  title        = {{Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort}},
  url          = {{http://dx.doi.org/10.1136/annrheumdis-2013-203854}},
  volume       = {{73}},
  year         = {{2014}},
}
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