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The role of vaccines for PRRS control and PRRSV eradication

Hans Nauwynck UGent, Ivan Trus, Isaura Christiaens UGent, Uladzimir Karniychuk, Ilias Frydas, Jun Cao UGent and Wander Van Breedam UGent (2012) EAAP Book of Abstracts. 18. p.72-72
abstract
After its first appearance in the late eighties, porcine reproductive and respiratory syndrome virus (PRRSV) caused for several years huge financial losses worldwide. Vaccines were developed shortly after, with big success. However, due to genetic drift, PRRSV was escaping more and more from vaccination immunity. At present, the original vaccines are no longer giving a full control of PRRS. Therefore, there is a need for adaptable vaccines that can be regularly updated. One should even think in the direction of auto-vaccines, based on farm-specific PRRSV isolates. Desperation drove farmers and veterinarians in the direction of ‘controlled infections’ with farm isolates with biosafety problems. Recently, a new methodology has been developed in our laboratory for adaptable inactivated vaccines with success. These vaccines allow to booster existing immunities in sows, giving a strong protection in sows and in the offspring via colostral immunity. This vaccine will not be the wonder product for naive animals. In this context, adaptable live vaccines are necessary. Because PRRSV starts with a replication in the respiratory tract, the induction of a local immunity would be most suitable. At present, adaptable attenuated and vector vaccines are under development in the author’s laboratory, based on new cellular and molecular insights of the PRRSV pathogenesis and immunity. A combination of adaptable attenuated/vector and inactivated vaccines will be the best tools to control and, if efficient enough, to eradicate PRRS.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
EAAP Book of Abstracts
volume
18
issue title
Book of abstracts of the 63rd annual meeting of the European Federation of Animal Science
article number
abstract 10a-2
pages
72 - 72
conference name
63rd Annual meeting of the European Federation of Animal Science
conference location
Bratislava, Slovakia
conference start
2012-08-27
conference end
2012-08-31
ISSN
1382-6077
ISBN
9789086862061
language
English
UGent publication?
yes
classification
C3
id
5984264
handle
http://hdl.handle.net/1854/LU-5984264
alternative location
http://www.eaap.org/Previous_Annual_Meetings/2012Bratislava/Bratislava_2012_Abstracts.pdf
date created
2015-06-07 16:33:07
date last changed
2016-12-21 15:41:05
@inproceedings{5984264,
  abstract     = {After its first appearance in the late eighties, porcine reproductive and respiratory syndrome virus (PRRSV) caused for several years huge financial losses worldwide. Vaccines were developed shortly after, with big success. However, due to genetic drift, PRRSV was escaping more and more from vaccination immunity. At present, the original vaccines are no longer giving a full control of PRRS. Therefore, there is a need for adaptable vaccines that can be regularly updated. One should even think in the direction of auto-vaccines, based on farm-specific PRRSV isolates. Desperation drove farmers and veterinarians in the direction of {\textquoteleft}controlled infections{\textquoteright} with farm isolates with biosafety problems. Recently, a new methodology has been developed in our laboratory for adaptable inactivated vaccines with success. These vaccines allow to booster existing immunities in sows, giving a strong protection in sows and in the offspring via colostral immunity. This vaccine will not be the wonder product for naive animals. In this context, adaptable live vaccines are necessary. Because PRRSV starts with a replication in the respiratory tract, the induction of a local immunity would be most suitable. At present, adaptable attenuated and vector vaccines are under development in the author{\textquoteright}s laboratory, based on new cellular and molecular insights of the PRRSV pathogenesis and immunity. A combination of adaptable attenuated/vector and inactivated vaccines will be the best tools to control and, if efficient enough, to eradicate PRRS.},
  articleno    = {abstract 10a-2},
  author       = {Nauwynck, Hans and Trus, Ivan and Christiaens, Isaura and Karniychuk, Uladzimir and Frydas, Ilias and Cao, Jun and Van Breedam, Wander},
  booktitle    = {EAAP Book of Abstracts},
  isbn         = {9789086862061},
  issn         = {1382-6077},
  language     = {eng},
  location     = {Bratislava, Slovakia},
  pages        = {abstract 10a-2:72--abstract 10a-2:72},
  title        = {The role of vaccines for PRRS control and PRRSV eradication},
  url          = {http://www.eaap.org/Previous\_Annual\_Meetings/2012Bratislava/Bratislava\_2012\_Abstracts.pdf},
  volume       = {18},
  year         = {2012},
}

Chicago
Nauwynck, Hans, Ivan Trus, Isaura Christiaens, Uladzimir Karniychuk, Ilias Frydas, Jun Cao, and Wander Van Breedam. 2012. “The Role of Vaccines for PRRS Control and PRRSV Eradication.” In EAAP Book of Abstracts, 18:72–72.
APA
Nauwynck, H., Trus, I., Christiaens, I., Karniychuk, U., Frydas, I., Cao, J., & Van Breedam, W. (2012). The role of vaccines for PRRS control and PRRSV eradication. EAAP Book of Abstracts (Vol. 18, pp. 72–72). Presented at the 63rd Annual meeting of the European Federation of Animal Science.
Vancouver
1.
Nauwynck H, Trus I, Christiaens I, Karniychuk U, Frydas I, Cao J, et al. The role of vaccines for PRRS control and PRRSV eradication. EAAP Book of Abstracts. 2012. p. 72–72.
MLA
Nauwynck, Hans, Ivan Trus, Isaura Christiaens, et al. “The Role of Vaccines for PRRS Control and PRRSV Eradication.” EAAP Book of Abstracts. Vol. 18. 2012. 72–72. Print.