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The immunity raised by recent European subtype 1 porcine reproductive and respiratory syndrome virus (PRRSV) strains allows spatial expansion of highly virulent East European subtype 3 PRRSV strains

Author
Organization
Project
PORRSCON (New tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia)
Abstract
Three subtypes of porcine reproductive and respiratory syndrome virus type 1 (PRRSV-1) are present in Europe. Subtype 1 strains are mainly present in the European Union. They cause severe reproductive problems (late abortion/early farrowing, stillbirth, weakborn piglets) but no or little general and respiratory problems. Subtype 2 and 3 strains are circulating in former member states of the Sovjet Union (e.g. Belarus). They are causing severe general and respiratory problems (high fever during 2-3 weeks, dyspnea and hyperpnea) and reproductive problems (similar to those described for subtype 1 strains). Despite the fear for the introduction of subtype 2 and 3 strains in the European Union, the spatial distribution of these PRRSV-1 subtypes in Europe has been surprisingly stable in the past. In the present study, we evaluated the potential of three West European subtype 1 PRRSV strains (07V063, isolated in 2007; 13V091, isolated in 2013 and 13V117, also isolated in 2013) to provide protection against the East European subtype 3 PRRSV strain Lena. Three groups of 11-week-old pigs were inoculated with either PRRSV 07V063 or PRRSV 13V091 or PRRSV 13V117. A fourth group was not inoculated (control group). Seven weeks later, the pigs of the four groups were challenged with the East European subtype 3 PRRSV strain Lena. Clinical, virological and serological parameters were monitored upon challenge with PRRSV Lena. The number of fever days was higher (P < 0.05) in the control group (7.6 ± 1.7 days) compared to animals from the three other groups (07V063-immunized: 4.0 ± 1.2 days, 13V091-immunized: 4.6 ± 1.1 days, 13V117-immunized: 4.0 ± 2.9 days). Reduction of respiratory disease and nasal shedding (mean AUC and mean peak values) was more pronounced in animals immunized with the 07V063 strain (P < 0.05) than in the two other groups. In all immunized groups, protection was characterized by a shorter (P < 0.05) viremia period (control group: 13.0 ± 4.8 days, 07V063-immunized: 5.4 ± 0.9 days, 13V091-immunized: 5.0 ± 0.0 days, 13V117-immunized: 5.8 ± 1.1 days). Our results indicate that immunity elicited by inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level at the respiratory tract (portal of entry) elicited by recently isolated subtype 1 PRRSV strains may form a danger for subtype 3 strains to spread in the European Union.
Keywords
Virus shedding, Viremia, Lena, Subtype, Spatial distribution, PRRSV, Adaptive immunity, Cross-protection, PRRS

Citation

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Chicago
Trus, Ivan, Ilias Frydas, Caroline Bonckaert, Vishwanatha Reddy Avalakuppa Papi Reddy, Yewei Li, Lise Kvisgaard, Lars Larsen, and Hans Nauwynck. 2014. “The Immunity Raised by Recent European Subtype 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Strains Allows Spatial Expansion of Highly Virulent East European Subtype 3 PRRSV Strains.” In First [sic] Annual Meeting Belgian Society for Virology.
APA
Trus, I., Frydas, I., Bonckaert, C., Avalakuppa Papi Reddy, V. R., Li, Y., Kvisgaard, L., Larsen, L., et al. (2014). The immunity raised by recent European subtype 1 porcine reproductive and respiratory syndrome virus (PRRSV) strains allows spatial expansion of highly virulent East European subtype 3 PRRSV strains. First [sic] annual meeting Belgian Society for Virology. Presented at the 2nd Annual meeting of the Belgian Society for Virology.
Vancouver
1.
Trus I, Frydas I, Bonckaert C, Avalakuppa Papi Reddy VR, Li Y, Kvisgaard L, et al. The immunity raised by recent European subtype 1 porcine reproductive and respiratory syndrome virus (PRRSV) strains allows spatial expansion of highly virulent East European subtype 3 PRRSV strains. First [sic] annual meeting Belgian Society for Virology. 2014.
MLA
Trus, Ivan, Ilias Frydas, Caroline Bonckaert, et al. “The Immunity Raised by Recent European Subtype 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Strains Allows Spatial Expansion of Highly Virulent East European Subtype 3 PRRSV Strains.” First [sic] Annual Meeting Belgian Society for Virology. 2014. Print.
@inproceedings{5980410,
  abstract     = {Three subtypes of porcine reproductive and respiratory syndrome virus type 1 (PRRSV-1) are present in Europe. Subtype 1 strains are mainly present in the European Union. They cause severe reproductive problems (late abortion/early farrowing, stillbirth, weakborn piglets) but no or little general and respiratory problems. Subtype 2 and 3 strains are circulating in former member states of the Sovjet Union (e.g. Belarus). They are causing severe general and respiratory problems (high fever during 2-3 weeks, dyspnea and hyperpnea) and reproductive problems (similar to those described for subtype 1 strains). Despite the fear for the introduction of subtype 2 and 3 strains in the European Union, the spatial distribution of these PRRSV-1 subtypes in Europe has been surprisingly stable in the past. In the present study, we evaluated the potential of three West European subtype 1 PRRSV strains (07V063, isolated in 2007; 13V091, isolated in 2013 and 13V117, also isolated in 2013) to provide protection against the East European subtype 3 PRRSV strain Lena. Three groups of 11-week-old pigs were inoculated with either PRRSV 07V063 or PRRSV 13V091 or PRRSV 13V117. A fourth group was not inoculated (control group). Seven weeks later, the pigs of the four groups were challenged with the East European subtype 3 PRRSV strain Lena. Clinical, virological and serological parameters were monitored upon challenge with PRRSV Lena. The number of fever days was higher (P {\textlangle} 0.05) in the control group (7.6 {\textpm} 1.7 days) compared to animals from the three other groups (07V063-immunized: 4.0 {\textpm} 1.2 days, 13V091-immunized: 4.6 {\textpm} 1.1 days, 13V117-immunized: 4.0 {\textpm} 2.9 days). Reduction of respiratory disease and nasal shedding (mean AUC and mean peak values) was more pronounced in animals immunized with the 07V063 strain (P {\textlangle} 0.05) than in the two other groups. In all immunized groups, protection was characterized by a shorter (P {\textlangle} 0.05) viremia period (control group: 13.0 {\textpm} 4.8 days, 07V063-immunized: 5.4 {\textpm} 0.9 days, 13V091-immunized: 5.0 {\textpm} 0.0 days, 13V117-immunized: 5.8 {\textpm} 1.1 days). Our results indicate that immunity elicited by inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level at the respiratory tract (portal of entry) elicited by recently isolated subtype 1 PRRSV strains may form a danger for subtype 3 strains to spread in the European Union.},
  articleno    = {abstract 21},
  author       = {Trus, Ivan and Frydas, Ilias and Bonckaert, Caroline and Avalakuppa Papi Reddy, Vishwanatha Reddy and Li, Yewei and Kvisgaard, Lise and Larsen, Lars and Nauwynck, Hans},
  booktitle    = {First [sic] annual meeting Belgian Society for Virology},
  language     = {eng},
  location     = {Brussels, Belgium},
  title        = {The immunity raised by recent European subtype 1 porcine reproductive and respiratory syndrome virus (PRRSV) strains allows spatial expansion of highly virulent East European subtype 3 PRRSV strains},
  url          = {http://www.dmipfmv.ulg.ac.be/vetimmuno/i/Program\%20and\%20abstract\%20book.pdf},
  year         = {2014},
}