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Local immunoglobulin E in the nasal mucosa: clinical implications

Els De Schryver UGent, LIEN DEVUYST, Lara Derycke UGent, Melissa Dullaers UGent, Thibaut Van Zele UGent, Claus Bachert UGent and Philippe Gevaert UGent (2015) ALLERGY ASTHMA & IMMUNOLOGY RESEARCH. 7(4). p.321-331
abstract
Immunoglobulin E (IgE) can be highly elevated in the airway mucosa independently of IgE serum levels and atopic status. Mostly, systemic markers are assessed to investigate inflammation in airway disease for research or clinical practice. A more accurate but more cumbersome approach to determine inflammation at the target organ would be to evaluate markers locally. We review evidence for local production of IgE in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Diagnostic and therapeutic consequences in clinical practice are discussed. We describe that the airway mucosa has the intrinsic capability to produce IgE. Moreover, not only do IgE-positive B cells reside within the mucosa, but all tools are present locally for affinity maturation by somatic hypermutation (SHM), clonal expansion, and class switch recombination to IgE. Recognizing local IgE in the absence of systemic IgE has diagnostic and therapeutic consequences. Therefore, we emphasize the importance of local IgE in patients with a history of AR or CRSwNP.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CLASS SWITCH RECOMBINATION, treatment, STAPHYLOCOCCUS-AUREUS ENTEROTOXINS, ALLERGIC-RHINITIS PATIENTS, GERMLINE GENE TRANSCRIPTS, EPSILON-HEAVY-CHAIN, B-CELLS, CHRONIC RHINOSINUSITIS, IGE ANTIBODIES, EOSINOPHILIC INFLAMMATION, PLASMA-CELLS, diagnostics, allergic rhinitis, local allergic rhinitis, local IgE, chronic rhinosinusitis with nasal polyps
journal title
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
Allergy Asthma Immunol. Res.
volume
7
issue
4
pages
321 - 331
Web of Science type
Review
Web of Science id
000357362200003
JCR category
ALLERGY
JCR impact factor
2.309 (2015)
JCR rank
15/25 (2015)
JCR quartile
3 (2015)
ISSN
2092-7355
DOI
10.4168/aair.2015.7.4.321
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
5962644
handle
http://hdl.handle.net/1854/LU-5962644
date created
2015-05-21 11:57:59
date last changed
2016-12-19 15:39:05
@article{5962644,
  abstract     = {Immunoglobulin E (IgE) can be highly elevated in the airway mucosa independently of IgE serum levels and atopic status. Mostly, systemic markers are assessed to investigate inflammation in airway disease for research or clinical practice. A more accurate but more cumbersome approach to determine inflammation at the target organ would be to evaluate markers locally. We review evidence for local production of IgE in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Diagnostic and therapeutic consequences in clinical practice are discussed. We describe that the airway mucosa has the intrinsic capability to produce IgE. Moreover, not only do IgE-positive B cells reside within the mucosa, but all tools are present locally for affinity maturation by somatic hypermutation (SHM), clonal expansion, and class switch recombination to IgE. Recognizing local IgE in the absence of systemic IgE has diagnostic and therapeutic consequences. Therefore, we emphasize the importance of local IgE in patients with a history of AR or CRSwNP.},
  author       = {De Schryver, Els and DEVUYST, LIEN and Derycke, Lara and Dullaers, Melissa and Van Zele, Thibaut and Bachert, Claus and Gevaert, Philippe},
  issn         = {2092-7355},
  journal      = {ALLERGY ASTHMA \& IMMUNOLOGY RESEARCH},
  keyword      = {CLASS SWITCH RECOMBINATION,treatment,STAPHYLOCOCCUS-AUREUS ENTEROTOXINS,ALLERGIC-RHINITIS PATIENTS,GERMLINE GENE TRANSCRIPTS,EPSILON-HEAVY-CHAIN,B-CELLS,CHRONIC RHINOSINUSITIS,IGE ANTIBODIES,EOSINOPHILIC INFLAMMATION,PLASMA-CELLS,diagnostics,allergic rhinitis,local allergic rhinitis,local IgE,chronic rhinosinusitis with nasal polyps},
  language     = {eng},
  number       = {4},
  pages        = {321--331},
  title        = {Local immunoglobulin E in the nasal mucosa: clinical implications},
  url          = {http://dx.doi.org/10.4168/aair.2015.7.4.321},
  volume       = {7},
  year         = {2015},
}

Chicago
De Schryver, Els, LIEN DEVUYST, Lara Derycke, Melissa Dullaers, Thibaut Van Zele, Claus Bachert, and Philippe Gevaert. 2015. “Local Immunoglobulin E in the Nasal Mucosa: Clinical Implications.” Allergy Asthma & Immunology Research 7 (4): 321–331.
APA
De Schryver, E., DEVUYST, L., Derycke, L., Dullaers, M., Van Zele, T., Bachert, C., & Gevaert, P. (2015). Local immunoglobulin E in the nasal mucosa: clinical implications. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 7(4), 321–331.
Vancouver
1.
De Schryver E, DEVUYST L, Derycke L, Dullaers M, Van Zele T, Bachert C, et al. Local immunoglobulin E in the nasal mucosa: clinical implications. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH. 2015;7(4):321–31.
MLA
De Schryver, Els, LIEN DEVUYST, Lara Derycke, et al. “Local Immunoglobulin E in the Nasal Mucosa: Clinical Implications.” ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 7.4 (2015): 321–331. Print.