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Local immunoglobulin E in the nasal mucosa : clinical implications

Els De Schryver (UGent) , LIEN DEVUYST (UGent) , Lara Derycke (UGent) , Melissa Dullaers (UGent) , Thibaut Van Zele (UGent) , Claus Bachert (UGent) and Philippe Gevaert (UGent)
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Abstract
Immunoglobulin E (IgE) can be highly elevated in the airway mucosa independently of IgE serum levels and atopic status. Mostly, systemic markers are assessed to investigate inflammation in airway disease for research or clinical practice. A more accurate but more cumbersome approach to determine inflammation at the target organ would be to evaluate markers locally. We review evidence for local production of IgE in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Diagnostic and therapeutic consequences in clinical practice are discussed. We describe that the airway mucosa has the intrinsic capability to produce IgE. Moreover, not only do IgE-positive B cells reside within the mucosa, but all tools are present locally for affinity maturation by somatic hypermutation (SHM), clonal expansion, and class switch recombination to IgE. Recognizing local IgE in the absence of systemic IgE has diagnostic and therapeutic consequences. Therefore, we emphasize the importance of local IgE in patients with a history of AR or CRSwNP.
Keywords
CLASS SWITCH RECOMBINATION, treatment, STAPHYLOCOCCUS-AUREUS ENTEROTOXINS, ALLERGIC-RHINITIS PATIENTS, GERMLINE GENE TRANSCRIPTS, EPSILON-HEAVY-CHAIN, B-CELLS, CHRONIC RHINOSINUSITIS, IGE ANTIBODIES, EOSINOPHILIC INFLAMMATION, PLASMA-CELLS, diagnostics, allergic rhinitis, local allergic rhinitis, local IgE, chronic rhinosinusitis with nasal polyps

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Chicago
De Schryver, Els, LIEN DEVUYST, Lara Derycke, Melissa Dullaers, Thibaut Van Zele, Claus Bachert, and Philippe Gevaert. 2015. “Local Immunoglobulin E in the Nasal Mucosa : Clinical Implications.” Allergy Asthma & Immunology Research 7 (4): 321–331.
APA
De Schryver, Els, DEVUYST, L., Derycke, L., Dullaers, M., Van Zele, T., Bachert, C., & Gevaert, P. (2015). Local immunoglobulin E in the nasal mucosa : clinical implications. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 7(4), 321–331.
Vancouver
1.
De Schryver E, DEVUYST L, Derycke L, Dullaers M, Van Zele T, Bachert C, et al. Local immunoglobulin E in the nasal mucosa : clinical implications. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH. 2015;7(4):321–31.
MLA
De Schryver, Els, LIEN DEVUYST, Lara Derycke, et al. “Local Immunoglobulin E in the Nasal Mucosa : Clinical Implications.” ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 7.4 (2015): 321–331. Print.
@article{5962644,
  abstract     = {Immunoglobulin E (IgE) can be highly elevated in the airway mucosa independently of IgE serum levels and atopic status. Mostly, systemic markers are assessed to investigate inflammation in airway disease for research or clinical practice. A more accurate but more cumbersome approach to determine inflammation at the target organ would be to evaluate markers locally. We review evidence for local production of IgE in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Diagnostic and therapeutic consequences in clinical practice are discussed. We describe that the airway mucosa has the intrinsic capability to produce IgE. Moreover, not only do IgE-positive B cells reside within the mucosa, but all tools are present locally for affinity maturation by somatic hypermutation (SHM), clonal expansion, and class switch recombination to IgE. Recognizing local IgE in the absence of systemic IgE has diagnostic and therapeutic consequences. Therefore, we emphasize the importance of local IgE in patients with a history of AR or CRSwNP.},
  author       = {De Schryver, Els and DEVUYST, LIEN and Derycke, Lara and Dullaers, Melissa and Van Zele, Thibaut and Bachert, Claus and Gevaert, Philippe},
  issn         = {2092-7355},
  journal      = {ALLERGY ASTHMA \& IMMUNOLOGY RESEARCH},
  keyword      = {CLASS SWITCH RECOMBINATION,treatment,STAPHYLOCOCCUS-AUREUS ENTEROTOXINS,ALLERGIC-RHINITIS PATIENTS,GERMLINE GENE TRANSCRIPTS,EPSILON-HEAVY-CHAIN,B-CELLS,CHRONIC RHINOSINUSITIS,IGE ANTIBODIES,EOSINOPHILIC INFLAMMATION,PLASMA-CELLS,diagnostics,allergic rhinitis,local allergic rhinitis,local IgE,chronic rhinosinusitis with nasal polyps},
  language     = {eng},
  number       = {4},
  pages        = {321--331},
  title        = {Local immunoglobulin E in the nasal mucosa : clinical implications},
  url          = {http://dx.doi.org/10.4168/aair.2015.7.4.321},
  volume       = {7},
  year         = {2015},
}

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