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Inhibition of quorum sensing in Staphylococcus spp.

Gilles Brackman (UGent) and Tom Coenye (UGent)
(2015) CURRENT PHARMACEUTICAL DESIGN. 21(16). p.2101-2108
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Abstract
The Gram-positive, facultative anaerobic coccus-shaped bacteria of the genus Staphylococcus are among the most important causative agents of acute and chronic bacterial infections in humans as well as in animals. Treatment of Staphylococcus infections has become increasingly challenging due to the growing problem of antibiotic resistance. For this reason innovative antimicrobials with novel targets and modes of action are needed. Since the discovery that QS is used by Staphylococcus spp. to coordinate the expression of several genes involved in virulence, biofilm formation and pathogenicity, QS inhibition has gained increasing attention as an alternative anti-pathogenic strategy. A major advantage compared with antibiotic therapy is that QSIs are used in concentrations that do not affect bacterial growth. For this reason, it is expected that these compounds would exert less pressure towards the development of resistance. However, some important points still need to be addressed. Although several inhibitors have proven to be active antipathogenic agents in vitro and in several in vivo models, it is still unknown whether these compounds will also be useful in humans. Furthermore, several fundamental mechanisms by which the different QS systems in Staphylococcus spp. exert their regulatory functions and how they are inhibited by QSIs are still poorly understood. In order to achieve real-life applications with QSIs, these challenges should be addressed and more research will be needed. In this article, we will discuss the different QS systems present in Staphylococcus spp., how they are used to control virulence and biofilm formation and how they can be blocked.
Keywords
Quorum sensing inhibition, Quorum sensing, Staphylococcus spp., GRAM-POSITIVE BACTERIA, ACCESSORY GENE REGULATOR, TO-CELL COMMUNICATION, SIGNAL-TRANSDUCTION SYSTEMS, BIOFILM FORMATION, AUREUS VIRULENCE, 5'-METHYLTHIOADENOSINE NUCLEOSIDASE, S-RIBOSYLHOMOCYSTEINASE, PEPTIDE INHIBITORS, ANALOG INHIBITORS

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Citation

Please use this url to cite or link to this publication:

Chicago
Brackman, Gilles, and Tom Coenye. 2015. “Inhibition of Quorum Sensing in Staphylococcus Spp.” Current Pharmaceutical Design 21 (16): 2101–2108.
APA
Brackman, G., & Coenye, T. (2015). Inhibition of quorum sensing in Staphylococcus spp. CURRENT PHARMACEUTICAL DESIGN, 21(16), 2101–2108.
Vancouver
1.
Brackman G, Coenye T. Inhibition of quorum sensing in Staphylococcus spp. CURRENT PHARMACEUTICAL DESIGN. 2015;21(16):2101–8.
MLA
Brackman, Gilles, and Tom Coenye. “Inhibition of Quorum Sensing in Staphylococcus Spp.” CURRENT PHARMACEUTICAL DESIGN 21.16 (2015): 2101–2108. Print.
@article{5956387,
  abstract     = {The Gram-positive, facultative anaerobic coccus-shaped bacteria of the genus Staphylococcus are among the most important causative agents of acute and chronic bacterial infections in humans as well as in animals. Treatment of Staphylococcus infections has become increasingly challenging due to the growing problem of antibiotic resistance. For this reason innovative antimicrobials with novel targets and modes of action are needed. Since the discovery that QS is used by Staphylococcus spp. to coordinate the expression of several genes involved in virulence, biofilm formation and pathogenicity, QS inhibition has gained increasing attention as an alternative anti-pathogenic strategy. A major advantage compared with antibiotic therapy is that QSIs are used in concentrations that do not affect bacterial growth. For this reason, it is expected that these compounds would exert less pressure towards the development of resistance. However, some important points still need to be addressed. Although several inhibitors have proven to be active antipathogenic agents in vitro and in several in vivo models, it is still unknown whether these compounds will also be useful in humans. Furthermore, several fundamental mechanisms by which the different QS systems in Staphylococcus spp. exert their regulatory functions and how they are inhibited by QSIs are still poorly understood. In order to achieve real-life applications with QSIs, these challenges should be addressed and more research will be needed. In this article, we will discuss the different QS systems present in Staphylococcus spp., how they are used to control virulence and biofilm formation and how they can be blocked.},
  author       = {Brackman, Gilles and Coenye, Tom},
  issn         = {1381-6128},
  journal      = {CURRENT PHARMACEUTICAL DESIGN},
  keyword      = {Quorum sensing inhibition,Quorum sensing,Staphylococcus spp.,GRAM-POSITIVE BACTERIA,ACCESSORY GENE REGULATOR,TO-CELL COMMUNICATION,SIGNAL-TRANSDUCTION SYSTEMS,BIOFILM FORMATION,AUREUS VIRULENCE,5'-METHYLTHIOADENOSINE NUCLEOSIDASE,S-RIBOSYLHOMOCYSTEINASE,PEPTIDE INHIBITORS,ANALOG INHIBITORS},
  language     = {eng},
  number       = {16},
  pages        = {2101--2108},
  title        = {Inhibition of quorum sensing in Staphylococcus spp.},
  volume       = {21},
  year         = {2015},
}

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