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Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study

Lies Lahousse UGent, Maartje N Niemeijer, Marten E van den Berg, Peter R Rijnbeek, Guy Joos UGent, Albert Hofman, Oscar H Franco, Jaap W Deckers, Mark Eijgelsheim, Bruno H Stricker, et al. (2015) EUROPEAN HEART JOURNAL. 36(27). p.1754-1761
abstract
Aims: Both sudden cardiac death (SCD) and chronic obstructive pulmonary disease (COPD) are common conditions in the elderly. Previous studies have identified an association betweenCOPDand cardiovascular disease, and with SCD in specific patient groups. Our aim was to investigate whether there is an association between COPD and SCD in the general population. Methods and results: The Rotterdam study is a population-based cohort study among 14 926 subjects aged 45 years and older with up to 24 years of follow-up. Analyses were performed with a (time dependent) Cox proportional hazard model adjusted for age, sex, and smoking. Of the 13 471 persons included in the analysis; 1615 had a diagnosis ofCOPDand therewere 551 cases of SCD. Chronic obstructive pulmonary disease was associated with an increased risk of SCD (age- and sex-adjusted hazard ratio, HR, 1.34, 95% CI 1.06–1.70). The risk particularly increased in the period 2000 days (5.48 years) after the diagnosis of COPD (age- and sex-adjusted HR 2.12, 95% CI 1.60–2.82) and increased further to a more than three-fold higher risk in COPD subjects with frequent exacerbations during this period (age- and sex-adjusted HR 3.58, 95% CI 2.35–5.44). Analyses restricted to persons without prevalent myocardial infarction or heart failure yielded similar results. Conclusion: Chronic obstructive pulmonary disease is associated with an increased risk for SCD. The risk especially increases in persons with frequent exacerbations 5 years after the diagnosis of COPD. This risk indicator could provide new directions for better-targeted actions to prevent SCD.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Comorbidity, Cardiovascular mortality, General population, Sudden cardiac death, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, SYSTEMIC INFLAMMATION, MYOCARDIAL-INFARCTION, ACUTE EXACERBATION, INCREASED RISK, LUNG-DISEASE, COPD, MORTALITY, MARKERS
journal title
EUROPEAN HEART JOURNAL
Eur. Heart J.
volume
36
issue
27
pages
1754 - 1761
Web of Science type
Article
Web of Science id
000358863200014
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
15.064 (2015)
JCR rank
3/124 (2015)
JCR quartile
1 (2015)
ISSN
0195-668X
DOI
10.1093/eurheartj/ehv121
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally
copyright statement
I have transferred the copyright for this publication to the publisher
id
5952594
handle
http://hdl.handle.net/1854/LU-5952594
date created
2015-05-08 13:54:56
date last changed
2016-12-19 15:39:02
@article{5952594,
  abstract     = {Aims: Both sudden cardiac death (SCD) and chronic obstructive pulmonary disease (COPD) are common conditions in the elderly. Previous studies have identified an association betweenCOPDand cardiovascular disease, and with SCD in specific patient groups. Our aim was to investigate whether there is an association between COPD and SCD in the general population.
Methods and results: The Rotterdam study is a population-based cohort study among 14 926 subjects aged 45 years and older with up to 24 years of follow-up. Analyses were performed with a (time dependent) Cox proportional hazard model adjusted for age, sex, and smoking. Of the 13 471 persons included in the analysis; 1615 had a diagnosis ofCOPDand therewere 551 cases of SCD. Chronic obstructive pulmonary disease was associated with an increased risk of SCD (age- and sex-adjusted hazard ratio, HR, 1.34, 95\% CI 1.06--1.70). The risk particularly increased in the period 2000 days (5.48 years) after the diagnosis of COPD (age- and sex-adjusted HR 2.12, 95\% CI 1.60--2.82) and increased further to a more than three-fold higher risk in COPD subjects with frequent exacerbations during this period (age- and sex-adjusted HR 3.58, 95\% CI 2.35--5.44). Analyses restricted to persons without prevalent myocardial infarction or heart failure yielded similar results.
Conclusion: Chronic obstructive pulmonary disease is associated with an increased risk for SCD. The risk especially increases in persons with frequent exacerbations 5 years after the diagnosis of COPD. This risk indicator could provide new directions for better-targeted actions to prevent SCD.},
  author       = {Lahousse, Lies and Niemeijer, Maartje N and van den Berg, Marten E and Rijnbeek, Peter R and Joos, Guy and Hofman, Albert and Franco, Oscar H and Deckers, Jaap W and Eijgelsheim, Mark and Stricker, Bruno H and Brusselle, Guy},
  issn         = {0195-668X},
  journal      = {EUROPEAN HEART JOURNAL},
  keyword      = {Comorbidity,Cardiovascular mortality,General population,Sudden cardiac death,C-REACTIVE PROTEIN,CARDIOVASCULAR-DISEASE,SYSTEMIC INFLAMMATION,MYOCARDIAL-INFARCTION,ACUTE EXACERBATION,INCREASED RISK,LUNG-DISEASE,COPD,MORTALITY,MARKERS},
  language     = {eng},
  number       = {27},
  pages        = {1754--1761},
  title        = {Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehv121},
  volume       = {36},
  year         = {2015},
}

Chicago
Lahousse, Lies, Maartje N Niemeijer, Marten E van den Berg, Peter R Rijnbeek, Guy Joos, Albert Hofman, Oscar H Franco, et al. 2015. “Chronic Obstructive Pulmonary Disease and Sudden Cardiac Death: The Rotterdam Study.” European Heart Journal 36 (27): 1754–1761.
APA
Lahousse, L., Niemeijer, M. N., van den Berg, M. E., Rijnbeek, P. R., Joos, G., Hofman, A., Franco, O. H., et al. (2015). Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study. EUROPEAN HEART JOURNAL, 36(27), 1754–1761.
Vancouver
1.
Lahousse L, Niemeijer MN, van den Berg ME, Rijnbeek PR, Joos G, Hofman A, et al. Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study. EUROPEAN HEART JOURNAL. 2015;36(27):1754–61.
MLA
Lahousse, Lies, Maartje N Niemeijer, Marten E van den Berg, et al. “Chronic Obstructive Pulmonary Disease and Sudden Cardiac Death: The Rotterdam Study.” EUROPEAN HEART JOURNAL 36.27 (2015): 1754–1761. Print.