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Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study

(2015) EUROPEAN HEART JOURNAL. 36(27). p.1754-1761
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Abstract
Aims: Both sudden cardiac death (SCD) and chronic obstructive pulmonary disease (COPD) are common conditions in the elderly. Previous studies have identified an association betweenCOPDand cardiovascular disease, and with SCD in specific patient groups. Our aim was to investigate whether there is an association between COPD and SCD in the general population. Methods and results: The Rotterdam study is a population-based cohort study among 14 926 subjects aged 45 years and older with up to 24 years of follow-up. Analyses were performed with a (time dependent) Cox proportional hazard model adjusted for age, sex, and smoking. Of the 13 471 persons included in the analysis; 1615 had a diagnosis ofCOPDand therewere 551 cases of SCD. Chronic obstructive pulmonary disease was associated with an increased risk of SCD (age- and sex-adjusted hazard ratio, HR, 1.34, 95% CI 1.06–1.70). The risk particularly increased in the period 2000 days (5.48 years) after the diagnosis of COPD (age- and sex-adjusted HR 2.12, 95% CI 1.60–2.82) and increased further to a more than three-fold higher risk in COPD subjects with frequent exacerbations during this period (age- and sex-adjusted HR 3.58, 95% CI 2.35–5.44). Analyses restricted to persons without prevalent myocardial infarction or heart failure yielded similar results. Conclusion: Chronic obstructive pulmonary disease is associated with an increased risk for SCD. The risk especially increases in persons with frequent exacerbations 5 years after the diagnosis of COPD. This risk indicator could provide new directions for better-targeted actions to prevent SCD.
Keywords
Comorbidity, Cardiovascular mortality, General population, Sudden cardiac death, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, SYSTEMIC INFLAMMATION, MYOCARDIAL-INFARCTION, ACUTE EXACERBATION, INCREASED RISK, LUNG-DISEASE, COPD, MORTALITY, MARKERS

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Citation

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Chicago
Lahousse, Lies, Maartje N Niemeijer, Marten E van den Berg, Peter R Rijnbeek, Guy Joos, Albert Hofman, Oscar H Franco, et al. 2015. “Chronic Obstructive Pulmonary Disease and Sudden Cardiac Death: The Rotterdam Study.” European Heart Journal 36 (27): 1754–1761.
APA
Lahousse, L., Niemeijer, M. N., van den Berg, M. E., Rijnbeek, P. R., Joos, G., Hofman, A., Franco, O. H., et al. (2015). Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study. EUROPEAN HEART JOURNAL, 36(27), 1754–1761.
Vancouver
1.
Lahousse L, Niemeijer MN, van den Berg ME, Rijnbeek PR, Joos G, Hofman A, et al. Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study. EUROPEAN HEART JOURNAL. 2015;36(27):1754–61.
MLA
Lahousse, Lies, Maartje N Niemeijer, Marten E van den Berg, et al. “Chronic Obstructive Pulmonary Disease and Sudden Cardiac Death: The Rotterdam Study.” EUROPEAN HEART JOURNAL 36.27 (2015): 1754–1761. Print.
@article{5952594,
  abstract     = {Aims: Both sudden cardiac death (SCD) and chronic obstructive pulmonary disease (COPD) are common conditions in the elderly. Previous studies have identified an association betweenCOPDand cardiovascular disease, and with SCD in specific patient groups. Our aim was to investigate whether there is an association between COPD and SCD in the general population.
Methods and results: The Rotterdam study is a population-based cohort study among 14 926 subjects aged 45 years and older with up to 24 years of follow-up. Analyses were performed with a (time dependent) Cox proportional hazard model adjusted for age, sex, and smoking. Of the 13 471 persons included in the analysis; 1615 had a diagnosis ofCOPDand therewere 551 cases of SCD. Chronic obstructive pulmonary disease was associated with an increased risk of SCD (age- and sex-adjusted hazard ratio, HR, 1.34, 95\% CI 1.06--1.70). The risk particularly increased in the period 2000 days (5.48 years) after the diagnosis of COPD (age- and sex-adjusted HR 2.12, 95\% CI 1.60--2.82) and increased further to a more than three-fold higher risk in COPD subjects with frequent exacerbations during this period (age- and sex-adjusted HR 3.58, 95\% CI 2.35--5.44). Analyses restricted to persons without prevalent myocardial infarction or heart failure yielded similar results.
Conclusion: Chronic obstructive pulmonary disease is associated with an increased risk for SCD. The risk especially increases in persons with frequent exacerbations 5 years after the diagnosis of COPD. This risk indicator could provide new directions for better-targeted actions to prevent SCD.},
  author       = {Lahousse, Lies and Niemeijer, Maartje N and van den Berg, Marten E and Rijnbeek, Peter R and Joos, Guy and Hofman, Albert and Franco, Oscar H and Deckers, Jaap W and Eijgelsheim, Mark and Stricker, Bruno H and Brusselle, Guy},
  issn         = {0195-668X},
  journal      = {EUROPEAN HEART JOURNAL},
  keyword      = {Comorbidity,Cardiovascular mortality,General population,Sudden cardiac death,C-REACTIVE PROTEIN,CARDIOVASCULAR-DISEASE,SYSTEMIC INFLAMMATION,MYOCARDIAL-INFARCTION,ACUTE EXACERBATION,INCREASED RISK,LUNG-DISEASE,COPD,MORTALITY,MARKERS},
  language     = {eng},
  number       = {27},
  pages        = {1754--1761},
  title        = {Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehv121},
  volume       = {36},
  year         = {2015},
}

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