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Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart

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Organization
Project
HPC-UGent: the central High Performance Computing infrastructure of Ghent University
Project
BOF 01SF1511
Abstract
Scroll waves are three-dimensional vortices which occur in excitable media. Their formation in the heart results in the onset of cardiac arrhythmias, and the dynamics of their filaments determine the arrhythmia type. Most studies of filament dynamics were performed in domains with simple geometries and generic description of the anisotropy of cardiac tissue. Recently, we developed an analytical model of fibre structure and anatomy of the left ventricle (LV) of the human heart. Here, we perform a systematic study of the dynamics of scroll wave filaments for the cases of positive and negative tension in this anatomical model. We study the various possible shapes of LV and different degree of anisotropy of cardiac tissue. We show that, for positive filament tension, the final position of scroll wave filament is mainly determined by the thickness of the myocardial wall but, however, anisotropy attracts the filament to the LV apex. For negative filament tension, the filament buckles, and for most cases, tends to the apex of the heart with no or slight dependency on the thickness of the LV. We discuss the mechanisms of the observed phenomena and their implications for cardiac arrhythmias.
Keywords
left ventricle, spiral wave tip, spiral wave, mathematical modelling, mathematical cardiology, scroll wave, filament, rotational anisotropy, SPIRAL WAVES, EXCITABLE MEDIA, ACTIVE MEDIUM, VORTEX, FIBRILLATION, PROPAGATION, TACHYCARDIA, MYOCARDIUM, EXCITATION, MECHANISM

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Citation

Please use this url to cite or link to this publication:

Chicago
Pravdin, Sergei, Hans Dierckx, Vladimir S Markhasin, and Alexander Panfilov. 2015. “Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart.” Biomed Research International.
APA
Pravdin, S., Dierckx, H., Markhasin, V. S., & Panfilov, A. (2015). Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart. BIOMED RESEARCH INTERNATIONAL.
Vancouver
1.
Pravdin S, Dierckx H, Markhasin VS, Panfilov A. Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart. BIOMED RESEARCH INTERNATIONAL. 2015;
MLA
Pravdin, Sergei et al. “Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart.” BIOMED RESEARCH INTERNATIONAL (2015): n. pag. Print.
@article{5943677,
  abstract     = {Scroll waves are three-dimensional vortices which occur in excitable media. Their formation in the heart results in the onset of cardiac arrhythmias, and the dynamics of their filaments determine the arrhythmia type. Most studies of filament dynamics were performed in domains with simple geometries and generic description of the anisotropy of cardiac tissue. Recently, we developed an analytical model of fibre structure and anatomy of the left ventricle (LV) of the human heart. Here, we perform a systematic study of the dynamics of scroll wave filaments for the cases of positive and negative tension in this anatomical model. We study the various possible shapes of LV and different degree of anisotropy of cardiac tissue. We show that, for positive filament tension, the final position of scroll wave filament is mainly determined by the thickness of the myocardial wall but, however, anisotropy attracts the filament to the LV apex. For negative filament tension, the filament buckles, and for most cases, tends to the apex of the heart with no or slight dependency on the thickness of the LV. We discuss the mechanisms of the observed phenomena and their implications for cardiac arrhythmias.},
  articleno    = {389830},
  author       = {Pravdin, Sergei and Dierckx, Hans and Markhasin, Vladimir S and Panfilov, Alexander},
  issn         = {2314-6133},
  journal      = {BIOMED RESEARCH INTERNATIONAL},
  keywords     = {left ventricle,spiral wave tip,spiral wave,mathematical modelling,mathematical cardiology,scroll wave,filament,rotational anisotropy,SPIRAL WAVES,EXCITABLE MEDIA,ACTIVE MEDIUM,VORTEX,FIBRILLATION,PROPAGATION,TACHYCARDIA,MYOCARDIUM,EXCITATION,MECHANISM},
  language     = {eng},
  pages        = {13},
  title        = {Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart},
  url          = {http://dx.doi.org/10.1155/2015/389830},
  year         = {2015},
}

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