Advanced search
1 file | 1.56 MB

The domestication of the probiotic bacterium Lactobacillus acidophilus

Author
Organization
Abstract
Lactobacillus acidophilus is a Gram-positive lactic acid bacterium that has had widespread historical use in the dairy industry and more recently as a probiotic. Although L. acidophilus has been designated as safe for human consumption, increasing commercial regulation and clinical demands for probiotic validation has resulted in a need to understand its genetic diversity. By drawing on large, well-characterised collections of lactic acid bacteria, we examined L. acidophilus isolates spanning 92 years and including multiple strains in current commercial use. Analysis of the whole genome sequence data set (34 isolate genomes) demonstrated L. acidophilus was a low diversity, monophyletic species with commercial isolates essentially identical at the sequence level. Our results indicate that commercial use has domesticated L. acidophilus with genetically stable, invariant strains being consumed globally by the human population.
Keywords
COMPARATIVE GENOMICS, LACTIC-ACID BACTERIA, SEQUENCE, STRAINS, COMPLEX, HEALTH, BIFIDOBACTERIUM, CONSUMPTION, RESISTANCE, CASEI

Downloads

  • 2014-Lb acidophilus.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.56 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Bull, Matthew J, Keith A Jolley, James E Bray, Maarten Aerts, Peter Vandamme, Martin CJ Maiden, Julian R Marchesi, and Eshwar Mahenthiralingam. 2014. “The Domestication of the Probiotic Bacterium Lactobacillus Acidophilus.” Scientific Reports 4.
APA
Bull, M. J., Jolley, K. A., Bray, J. E., Aerts, M., Vandamme, P., Maiden, M. C., Marchesi, J. R., et al. (2014). The domestication of the probiotic bacterium Lactobacillus acidophilus. SCIENTIFIC REPORTS, 4.
Vancouver
1.
Bull MJ, Jolley KA, Bray JE, Aerts M, Vandamme P, Maiden MC, et al. The domestication of the probiotic bacterium Lactobacillus acidophilus. SCIENTIFIC REPORTS. 2014;4.
MLA
Bull, Matthew J, Keith A Jolley, James E Bray, et al. “The Domestication of the Probiotic Bacterium Lactobacillus Acidophilus.” SCIENTIFIC REPORTS 4 (2014): n. pag. Print.
@article{5941464,
  abstract     = {Lactobacillus acidophilus is a Gram-positive lactic acid bacterium that has had widespread historical use in the dairy industry and more recently as a probiotic. Although L. acidophilus has been designated as safe for human consumption, increasing commercial regulation and clinical demands for probiotic validation has resulted in a need to understand its genetic diversity. By drawing on large, well-characterised collections of lactic acid bacteria, we examined L. acidophilus isolates spanning 92 years and including multiple strains in current commercial use. Analysis of the whole genome sequence data set (34 isolate genomes) demonstrated L. acidophilus was a low diversity, monophyletic species with commercial isolates essentially identical at the sequence level. Our results indicate that commercial use has domesticated L. acidophilus with genetically stable, invariant strains being consumed globally by the human population.},
  articleno    = {7202},
  author       = {Bull, Matthew J and Jolley, Keith A and Bray, James E and Aerts, Maarten and Vandamme, Peter and Maiden, Martin CJ and Marchesi, Julian R and Mahenthiralingam, Eshwar},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {COMPARATIVE GENOMICS,LACTIC-ACID BACTERIA,SEQUENCE,STRAINS,COMPLEX,HEALTH,BIFIDOBACTERIUM,CONSUMPTION,RESISTANCE,CASEI},
  language     = {eng},
  pages        = {8},
  title        = {The domestication of the probiotic bacterium Lactobacillus acidophilus},
  url          = {http://dx.doi.org/10.1038/srep07202},
  volume       = {4},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: