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The domestication of the probiotic bacterium Lactobacillus acidophilus

Matthew J Bull, Keith A Jolley, James E Bray, Maarten Aerts, Peter Vandamme UGent, Martin CJ Maiden, Julian R Marchesi and Eshwar Mahenthiralingam (2014) SCIENTIFIC REPORTS. 4.
abstract
Lactobacillus acidophilus is a Gram-positive lactic acid bacterium that has had widespread historical use in the dairy industry and more recently as a probiotic. Although L. acidophilus has been designated as safe for human consumption, increasing commercial regulation and clinical demands for probiotic validation has resulted in a need to understand its genetic diversity. By drawing on large, well-characterised collections of lactic acid bacteria, we examined L. acidophilus isolates spanning 92 years and including multiple strains in current commercial use. Analysis of the whole genome sequence data set (34 isolate genomes) demonstrated L. acidophilus was a low diversity, monophyletic species with commercial isolates essentially identical at the sequence level. Our results indicate that commercial use has domesticated L. acidophilus with genetically stable, invariant strains being consumed globally by the human population.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
COMPARATIVE GENOMICS, LACTIC-ACID BACTERIA, SEQUENCE, STRAINS, COMPLEX, HEALTH, BIFIDOBACTERIUM, CONSUMPTION, RESISTANCE, CASEI
journal title
SCIENTIFIC REPORTS
Sci. Rep.
volume
4
article number
7202
pages
8 pages
Web of Science type
Article
Web of Science id
000346196300001
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
5.578 (2014)
JCR rank
5/57 (2014)
JCR quartile
1 (2014)
ISSN
2045-2322
DOI
10.1038/srep07202
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
5941464
handle
http://hdl.handle.net/1854/LU-5941464
date created
2015-04-22 18:07:58
date last changed
2016-12-21 15:41:23
@article{5941464,
  abstract     = {Lactobacillus acidophilus is a Gram-positive lactic acid bacterium that has had widespread historical use in the dairy industry and more recently as a probiotic. Although L. acidophilus has been designated as safe for human consumption, increasing commercial regulation and clinical demands for probiotic validation has resulted in a need to understand its genetic diversity. By drawing on large, well-characterised collections of lactic acid bacteria, we examined L. acidophilus isolates spanning 92 years and including multiple strains in current commercial use. Analysis of the whole genome sequence data set (34 isolate genomes) demonstrated L. acidophilus was a low diversity, monophyletic species with commercial isolates essentially identical at the sequence level. Our results indicate that commercial use has domesticated L. acidophilus with genetically stable, invariant strains being consumed globally by the human population.},
  articleno    = {7202},
  author       = {Bull, Matthew J and Jolley, Keith A and Bray, James E and Aerts, Maarten and Vandamme, Peter and Maiden, Martin CJ and Marchesi, Julian R and Mahenthiralingam, Eshwar},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {COMPARATIVE GENOMICS,LACTIC-ACID BACTERIA,SEQUENCE,STRAINS,COMPLEX,HEALTH,BIFIDOBACTERIUM,CONSUMPTION,RESISTANCE,CASEI},
  language     = {eng},
  pages        = {8},
  title        = {The domestication of the probiotic bacterium Lactobacillus acidophilus},
  url          = {http://dx.doi.org/10.1038/srep07202},
  volume       = {4},
  year         = {2014},
}

Chicago
Bull, Matthew J, Keith A Jolley, James E Bray, Maarten Aerts, Peter Vandamme, Martin CJ Maiden, Julian R Marchesi, and Eshwar Mahenthiralingam. 2014. “The Domestication of the Probiotic Bacterium Lactobacillus Acidophilus.” Scientific Reports 4.
APA
Bull, M. J., Jolley, K. A., Bray, J. E., Aerts, M., Vandamme, P., Maiden, M. C., Marchesi, J. R., et al. (2014). The domestication of the probiotic bacterium Lactobacillus acidophilus. SCIENTIFIC REPORTS, 4.
Vancouver
1.
Bull MJ, Jolley KA, Bray JE, Aerts M, Vandamme P, Maiden MC, et al. The domestication of the probiotic bacterium Lactobacillus acidophilus. SCIENTIFIC REPORTS. 2014;4.
MLA
Bull, Matthew J, Keith A Jolley, James E Bray, et al. “The Domestication of the Probiotic Bacterium Lactobacillus Acidophilus.” SCIENTIFIC REPORTS 4 (2014): n. pag. Print.