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Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study

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Abstract
OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%. STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears. RESULTS: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003). CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.
Keywords
MANAGEMENT, SQUAMOUS-CELL CARCINOMA, vaginal intraepithelial neoplasia, Papanicolaou smears, cervical intraepithelial neoplasia, hysterectomy, CANCER, CONIZATION, SMEARS, WOMEN, RISK

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Chicago
Schokkaert, Silke, Willy Poppe, Marc Arbyn, Tom Verguts, and Jasper Verguts. 2008. “Incidence of Vaginal Intraepithelial Neoplasia After Hysterectomy for Cervical Intraepithelial Neoplasia: a Retrospective Study.” American Journal of Obstetrics and Gynecology 199 (2).
APA
Schokkaert, S., Poppe, W., Arbyn, M., Verguts, T., & Verguts, J. (2008). Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 199(2).
Vancouver
1.
Schokkaert S, Poppe W, Arbyn M, Verguts T, Verguts J. Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. New York ; UNITED STATES: MOSBY-ELSEVIER; 2008;199(2).
MLA
Schokkaert, Silke, Willy Poppe, Marc Arbyn, et al. “Incidence of Vaginal Intraepithelial Neoplasia After Hysterectomy for Cervical Intraepithelial Neoplasia: a Retrospective Study.” AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 199.2 (2008): n. pag. Print.
@article{594094,
  abstract     = {OBJECTIVE: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9\% to 6.8\%.

STUDY DESIGN: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.

RESULTS: Thirty-one patients (24.8\%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4\%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003).

CONCLUSION: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4\%.},
  author       = {Schokkaert, Silke and Poppe, Willy and Arbyn, Marc and Verguts, Tom and Verguts, Jasper},
  issn         = {0002-9378},
  journal      = {AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY},
  keyword      = {MANAGEMENT,SQUAMOUS-CELL CARCINOMA,vaginal intraepithelial neoplasia,Papanicolaou smears,cervical intraepithelial neoplasia,hysterectomy,CANCER,CONIZATION,SMEARS,WOMEN,RISK},
  language     = {eng},
  number       = {2},
  publisher    = {MOSBY-ELSEVIER},
  title        = {Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study},
  url          = {http://dx.doi.org/10.1016/j.ajog.2008.02.026},
  volume       = {199},
  year         = {2008},
}

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