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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

(2001) NATURE GENETICS. 28(2). p.131-138
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Abstract
Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here, we report that deletion of the hypoxia-response element in the Vegf promotor reduced hypoxic Vegf expression in the spinal cord and caused adult-onset progressive motor neuron degeneration, reminiscent of amyotrophic lateral sclerosis, The neurodegeneration seemed to be due to reduced neural vascular perfusion. In addition. Vegf(165) promoted survival of motor neurons during hypoxia through binding to Vegf receptor 2 and neuropilin 1. Acute ischemia is known to cause nonselective neuronal death. Our results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons.
Keywords
SPINAL-CORD, ANGIOGENESIS, INDUCIBLE FACTOR-1, AMYOTROPHIC-LATERAL-SCLEROSIS, FACTOR MESSENGER-RNA, FACTOR EXPRESSION, NERVOUS-SYSTEM, ISCHEMIA, MODEL, VEGF

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MLA
Oosthuyse, Bert et al. “Deletion of the Hypoxia-response Element in the Vascular Endothelial Growth Factor Promoter Causes Motor Neuron Degeneration.” NATURE GENETICS 28.2 (2001): 131–138. Print.
APA
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Van Dorpe, J., et al. (2001). Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. NATURE GENETICS, 28(2), 131–138.
Chicago author-date
Oosthuyse, Bert, Lieve Moons, Erik Storkebaum, Heike Beck, Dieter Nuyens, Koen Brusselmans, Jo Van Dorpe, et al. 2001. “Deletion of the Hypoxia-response Element in the Vascular Endothelial Growth Factor Promoter Causes Motor Neuron Degeneration.” Nature Genetics 28 (2): 131–138.
Chicago author-date (all authors)
Oosthuyse, Bert, Lieve Moons, Erik Storkebaum, Heike Beck, Dieter Nuyens, Koen Brusselmans, Jo Van Dorpe, Peter Hellings, Marchel Gorselink, Stéphane Heymans, Gregor Theilmeier, Mieke Dewerchin, Vincent Laudenbach, Patrick Vermylen, Harold Raat, Till Acker, Vicky Vleminckx, Ludo Van den Bosch, Neil Cashman, Hajime Fujisawa, Maarten R Drost, Raf Sciot, Frans Bruyninckx, Daniel J Hicklin, Can Ince, Pierre Gressens, Florea Lupu, Karl H Plate, Wim Robberecht, Jean-Marc Herbert, Désiré Collen, and Peter Carmeliet. 2001. “Deletion of the Hypoxia-response Element in the Vascular Endothelial Growth Factor Promoter Causes Motor Neuron Degeneration.” Nature Genetics 28 (2): 131–138.
Vancouver
1.
Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. NATURE GENETICS. 2001;28(2):131–8.
IEEE
[1]
B. Oosthuyse et al., “Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration,” NATURE GENETICS, vol. 28, no. 2, pp. 131–138, 2001.
@article{5940666,
  abstract     = {Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here, we report that deletion of the hypoxia-response element in the Vegf promotor reduced hypoxic Vegf expression in the spinal cord and caused adult-onset progressive motor neuron degeneration, reminiscent of amyotrophic lateral sclerosis, The neurodegeneration seemed to be due to reduced neural vascular perfusion. In addition. Vegf(165) promoted survival of motor neurons during hypoxia through binding to Vegf receptor 2 and neuropilin 1. Acute ischemia is known to cause nonselective neuronal death. Our results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons.},
  author       = {Oosthuyse, Bert and Moons, Lieve and Storkebaum, Erik and Beck, Heike and Nuyens, Dieter and Brusselmans, Koen and Van Dorpe, Jo and Hellings, Peter and Gorselink, Marchel and Heymans, Stéphane and Theilmeier, Gregor and Dewerchin, Mieke and Laudenbach, Vincent and Vermylen, Patrick and Raat, Harold and Acker, Till and Vleminckx, Vicky and Van den Bosch, Ludo and Cashman, Neil and Fujisawa, Hajime and Drost, Maarten R and Sciot, Raf and Bruyninckx, Frans and Hicklin, Daniel J and Ince, Can and Gressens, Pierre and Lupu, Florea and Plate, Karl H and Robberecht, Wim and Herbert, Jean-Marc and Collen, Désiré and Carmeliet, Peter},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keywords     = {SPINAL-CORD,ANGIOGENESIS,INDUCIBLE FACTOR-1,AMYOTROPHIC-LATERAL-SCLEROSIS,FACTOR MESSENGER-RNA,FACTOR EXPRESSION,NERVOUS-SYSTEM,ISCHEMIA,MODEL,VEGF},
  language     = {eng},
  number       = {2},
  pages        = {131--138},
  title        = {Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration},
  url          = {http://dx.doi.org/10.1038/88842},
  volume       = {28},
  year         = {2001},
}

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