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Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma)

(2002) VIRCHOWS ARCHIV. 440(5). p.485-490
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Abstract
Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However. using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2. 12, and 15, with a cryptic rearrangement of the gene (HMGI-C HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.
Keywords
cartilage-containing benign mesenchymoma fluorescence in situ, chondrolipoangioma, hybridization, conventional cytogenetic analysis, HMGI-C, HMGA2, TUMORS, DYSREGULATION, SERIES

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Citation

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MLA
Van Dorpe, Jo et al. “Translocation of the HMGI-C (HMGA2) Gene in a Benign Mesenchymoma (chondrolipoangioma).” VIRCHOWS ARCHIV 440.5 (2002): 485–490. Print.
APA
Van Dorpe, J., Dal Cin, P., Weremowicz, S., Van Leuven, F., de Wever, I., Van den Berghe, H., Fletcher, C. D., et al. (2002). Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). VIRCHOWS ARCHIV, 440(5), 485–490.
Chicago author-date
Van Dorpe, Jo, Paola Dal Cin, Stanislawa Weremowicz, Fred Van Leuven, Ivo de Wever, Herman Van den Berghe, Christopher DM Fletcher, and Raf Sciot. 2002. “Translocation of the HMGI-C (HMGA2) Gene in a Benign Mesenchymoma (chondrolipoangioma).” Virchows Archiv 440 (5): 485–490.
Chicago author-date (all authors)
Van Dorpe, Jo, Paola Dal Cin, Stanislawa Weremowicz, Fred Van Leuven, Ivo de Wever, Herman Van den Berghe, Christopher DM Fletcher, and Raf Sciot. 2002. “Translocation of the HMGI-C (HMGA2) Gene in a Benign Mesenchymoma (chondrolipoangioma).” Virchows Archiv 440 (5): 485–490.
Vancouver
1.
Van Dorpe J, Dal Cin P, Weremowicz S, Van Leuven F, de Wever I, Van den Berghe H, et al. Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). VIRCHOWS ARCHIV. 2002;440(5):485–90.
IEEE
[1]
J. Van Dorpe et al., “Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma),” VIRCHOWS ARCHIV, vol. 440, no. 5, pp. 485–490, 2002.
@article{5940618,
  abstract     = {Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However. using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2. 12, and 15, with a cryptic rearrangement of the gene (HMGI-C HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.},
  author       = {Van Dorpe, Jo and Dal Cin, Paola and Weremowicz, Stanislawa and Van Leuven, Fred and de Wever, Ivo and Van den Berghe, Herman and Fletcher, Christopher DM and Sciot, Raf},
  issn         = {0945-6317},
  journal      = {VIRCHOWS ARCHIV},
  keywords     = {cartilage-containing benign mesenchymoma fluorescence in situ,chondrolipoangioma,hybridization,conventional cytogenetic analysis,HMGI-C,HMGA2,TUMORS,DYSREGULATION,SERIES},
  language     = {eng},
  number       = {5},
  pages        = {485--490},
  title        = {Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma)},
  url          = {http://dx.doi.org/10.1007/s00428-001-0547-z},
  volume       = {440},
  year         = {2002},
}

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