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Relation between left ventricular relaxation rate and arterial loading

Tom Claessens (UGent) , Ernst Rietzschel (UGent) , Marc De Buyzere (UGent) , Dirk De Bacquer (UGent) , Gui De Backer (UGent) , Thierry Gillebert (UGent) , Pascal Verdonck (UGent) and Patrick Segers (UGent)
(2008) IFMBE Proceedings. 22. p.1918-1921
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Abstract
A number of studies suggested a relation between reduced left ventricular (LV) relaxation rate and increased arterial stiffness. In the present study we aimed (i) to investigate whether this association is inherently present in apparently healthy, middle-aged individuals, and (ii) to determine to what extent this association is modulated by age and/or body or heart size. 2239 subjects (1151 M and 1088 F) aged between 35 and 55 years (median 46 years) at the initiation of the study, free from overt cardiovascular disease and participating in the Asklepios study, were included in this study. Important bivariate correlations were observed between diastolic function and various arterial function parameters. In both men and women a pronounced relation was found between the carotid distensibility coefficient and LV relaxation rate, assessed as mitral annular early diastolic velocity (E'). A multiple linear regression model, however, proved age to be the primary independent determinant of E', followed by LV mass. Inclusion of the remaining arterial function variables only marginally increased the model's predictive capacity. The presumably direct relationship between E' and arterial stiffness is thus largely mediated by age and to a lesser extent by LV mass.
Keywords
afterload, stiffness, relaxation, left ventricle, reflection, diastole

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Chicago
Claessens, Tom, Ernst Rietzschel, MARC DE BUYZERE, Dirk De Bacquer, Gui De Backer, Thierry Gillebert, Pascal Verdonck, and Patrick Segers. 2008. “Relation Between Left Ventricular Relaxation Rate and Arterial Loading.” In IFMBE Proceedings, ed. Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, and Jens Haueisen, 22:1918–1921. New York, NY, USA: Springer.
APA
Claessens, Tom, Rietzschel, E., DE BUYZERE, M., De Bacquer, D., De Backer, G., Gillebert, T., Verdonck, P., et al. (2008). Relation between left ventricular relaxation rate and arterial loading. In Jos Vander Sloten, P. Verdonck, M. Nyssen, & J. Haueisen (Eds.), IFMBE Proceedings (Vol. 22, pp. 1918–1921). Presented at the 4th European conference of the International Federation for Medical and Biological Engineering ; 4th European congress for Medical and Biomedical Engineering, New York, NY, USA: Springer.
Vancouver
1.
Claessens T, Rietzschel E, DE BUYZERE M, De Bacquer D, De Backer G, Gillebert T, et al. Relation between left ventricular relaxation rate and arterial loading. In: Vander Sloten J, Verdonck P, Nyssen M, Haueisen J, editors. IFMBE Proceedings. New York, NY, USA: Springer; 2008. p. 1918–21.
MLA
Claessens, Tom, Ernst Rietzschel, MARC DE BUYZERE, et al. “Relation Between Left Ventricular Relaxation Rate and Arterial Loading.” IFMBE Proceedings. Ed. Jos Vander Sloten et al. Vol. 22. New York, NY, USA: Springer, 2008. 1918–1921. Print.
@inproceedings{593820,
  abstract     = {A number of studies suggested a relation between reduced left ventricular (LV) relaxation rate and increased arterial stiffness. In the present study we aimed (i) to investigate whether this association is inherently present in apparently healthy, middle-aged individuals, and (ii) to determine to what extent this association is modulated by age and/or body or heart size. 
2239 subjects (1151 M and 1088 F) aged between 35 and 55 years (median 46 years) at the initiation of the study, free from overt cardiovascular disease and participating in the Asklepios study, were included in this study. 
Important bivariate correlations were observed between diastolic function and various arterial function parameters. In both men and women a pronounced relation was found between the carotid distensibility coefficient and LV relaxation rate, assessed as mitral annular early diastolic velocity (E'). 
A multiple linear regression model, however, proved age to be the primary independent determinant of E', followed by LV mass. Inclusion of the remaining arterial function variables only marginally increased the model's predictive capacity. The presumably direct relationship between E' and arterial stiffness is thus largely mediated by age and to a lesser extent by LV mass.},
  author       = {Claessens, Tom and Rietzschel, Ernst and De Buyzere, Marc and De Bacquer, Dirk and De Backer, Gui and Gillebert, Thierry and Verdonck, Pascal and Segers, Patrick},
  booktitle    = {IFMBE Proceedings},
  editor       = {Vander Sloten, Jos and Verdonck, Pascal and Nyssen, Marc and Haueisen, Jens},
  isbn         = {9783540892076},
  issn         = {1680-0737},
  language     = {eng},
  location     = {Antwerp, Belgium},
  pages        = {1918--1921},
  publisher    = {Springer},
  title        = {Relation between left ventricular relaxation rate and arterial loading},
  url          = {http://dx.doi.org/10.1007/978-3-540-89208-3\_457},
  volume       = {22},
  year         = {2008},
}

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