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Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring

I Torres-Espallardo, Faruk Diblen, H Rohling, P Solevi, J Gillam, D Watts, Samuel Espana Palomares, Stefaan Vandenberghe UGent, F Fiedler and M Rafecas (2015) PHYSICS IN MEDICINE AND BIOLOGY. 60(9). p.N187-N208
abstract
Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scannerbeam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options. based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
range deviation, RPC, in-beam, PET, partial-ring, particle therapy, TOF, POSITRON-EMISSION-TOMOGRAPHY, TIME-OF-FLIGHT, PROTON THERAPY, RADIOTHERAPY, RANGE, RECONSTRUCTION, VERIFICATION, IRRADIATION, DETECTORS, DELIVERY
journal title
PHYSICS IN MEDICINE AND BIOLOGY
Phys. Med. Biol.
volume
60
issue
9
pages
N187 - N208
Web of Science type
Article
Web of Science id
000354104700003
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.811 (2015)
JCR rank
19/76 (2015)
JCR quartile
1 (2015)
ISSN
0031-9155
DOI
10.1088/0031-9155/60/9/N187
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5938090
handle
http://hdl.handle.net/1854/LU-5938090
alternative location
http://iopscience.iop.org/0031-9155/60/9/N187/pdf/0031-9155_60_9_N187.pdf
date created
2015-04-20 14:12:08
date last changed
2016-12-19 15:47:28
@article{5938090,
  abstract     = {Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scannerbeam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options. based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron},
  author       = {Torres-Espallardo, I and Diblen, Faruk and Rohling, H and Solevi, P and Gillam, J and Watts, D and Espana Palomares, Samuel and Vandenberghe, Stefaan and Fiedler, F and Rafecas, M},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  keyword      = {range deviation,RPC,in-beam,PET,partial-ring,particle therapy,TOF,POSITRON-EMISSION-TOMOGRAPHY,TIME-OF-FLIGHT,PROTON THERAPY,RADIOTHERAPY,RANGE,RECONSTRUCTION,VERIFICATION,IRRADIATION,DETECTORS,DELIVERY},
  language     = {eng},
  number       = {9},
  pages        = {N187--N208},
  title        = {Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring},
  url          = {http://dx.doi.org/10.1088/0031-9155/60/9/N187},
  volume       = {60},
  year         = {2015},
}

Chicago
Torres-Espallardo, I, Faruk Diblen, H Rohling, P Solevi, J Gillam, D Watts, Samuel Espana Palomares, Stefaan Vandenberghe, F Fiedler, and M Rafecas. 2015. “Evaluation of Resistive-plate-chamber-based TOF-PET Applied to In-beam Particle Therapy Monitoring.” Physics in Medicine and Biology 60 (9): N187–N208.
APA
Torres-Espallardo, I., Diblen, F., Rohling, H., Solevi, P., Gillam, J., Watts, D., Espana Palomares, S., et al. (2015). Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring. PHYSICS IN MEDICINE AND BIOLOGY, 60(9), N187–N208.
Vancouver
1.
Torres-Espallardo I, Diblen F, Rohling H, Solevi P, Gillam J, Watts D, et al. Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring. PHYSICS IN MEDICINE AND BIOLOGY. 2015;60(9):N187–N208.
MLA
Torres-Espallardo, I, Faruk Diblen, H Rohling, et al. “Evaluation of Resistive-plate-chamber-based TOF-PET Applied to In-beam Particle Therapy Monitoring.” PHYSICS IN MEDICINE AND BIOLOGY 60.9 (2015): N187–N208. Print.