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We are all individuals...: bioinformatics in the personalized medicine era

(2015) CELLULAR ONCOLOGY. 38(1). p.29-37
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Abstract
The medical landscape is evolving at a rapid pace, creating the opportunity for more personalized patient treatment and shifting the way healthcare is approached and thought about. With the availability of (epi)genome-wide, transcriptomic and proteogenomic profiling techniques detailed characterization of a disease at the level of the individual is now possible, offering the opportunity for truly tailored approaches for treatment and patient care. While improvements are still expected, the techniques and the basic analytical tools have reached a state that these can be efficiently deployed in both routine research and clinical practice. Still, some major challenges remain. Notably, holistic approaches, integrating data from several sources, e.g. genomic and epigenomic, will increase the understanding of the underlying biological concepts and provide insight into the causes, effects and effective solutions. However, creating and validating such a knowledge base, potentially for different levels of expertise, and integrating several data points into meaningful information is not trivial.
Keywords
Personalized medicine, Bioinformatics, Epigenetics, Genetics, Pharmacogenomics, Biomarkers, METHYLATION-SPECIFIC PCR, SPORADIC BREAST-CANCER, HUMAN GENOME, COLORECTAL-CANCER, SOMATIC MUTATIONS, DNA METHYLATION, LUNG-CANCER, O-6-METHYLGUANINE-DNA METHYLTRANSFERASE, PROMOTER HYPERMETHYLATION, THERAPEUTIC VACCINATION

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Citation

Please use this url to cite or link to this publication:

MLA
Van Neste, Leander, and Wim Van Criekinge. “We Are All Individuals...: Bioinformatics in the Personalized Medicine Era.” CELLULAR ONCOLOGY 38.1 (2015): 29–37. Print.
APA
Van Neste, L., & Van Criekinge, W. (2015). We are all individuals...: bioinformatics in the personalized medicine era. CELLULAR ONCOLOGY, 38(1), 29–37.
Chicago author-date
Van Neste, Leander, and Wim Van Criekinge. 2015. “We Are All Individuals...: Bioinformatics in the Personalized Medicine Era.” Cellular Oncology 38 (1): 29–37.
Chicago author-date (all authors)
Van Neste, Leander, and Wim Van Criekinge. 2015. “We Are All Individuals...: Bioinformatics in the Personalized Medicine Era.” Cellular Oncology 38 (1): 29–37.
Vancouver
1.
Van Neste L, Van Criekinge W. We are all individuals...: bioinformatics in the personalized medicine era. CELLULAR ONCOLOGY. 2015;38(1):29–37.
IEEE
[1]
L. Van Neste and W. Van Criekinge, “We are all individuals...: bioinformatics in the personalized medicine era,” CELLULAR ONCOLOGY, vol. 38, no. 1, pp. 29–37, 2015.
@article{5936679,
  abstract     = {The medical landscape is evolving at a rapid pace, creating the opportunity for more personalized patient treatment and shifting the way healthcare is approached and thought about. With the availability of (epi)genome-wide, transcriptomic and proteogenomic profiling techniques detailed characterization of a disease at the level of the individual is now possible, offering the opportunity for truly tailored approaches for treatment and patient care. While improvements are still expected, the techniques and the basic analytical tools have reached a state that these can be efficiently deployed in both routine research and clinical practice. Still, some major challenges remain. Notably, holistic approaches, integrating data from several sources, e.g. genomic and epigenomic, will increase the understanding of the underlying biological concepts and provide insight into the causes, effects and effective solutions. However, creating and validating such a knowledge base, potentially for different levels of expertise, and integrating several data points into meaningful information is not trivial.},
  author       = {Van Neste, Leander and Van Criekinge, Wim},
  issn         = {2211-3428},
  journal      = {CELLULAR ONCOLOGY},
  keywords     = {Personalized medicine,Bioinformatics,Epigenetics,Genetics,Pharmacogenomics,Biomarkers,METHYLATION-SPECIFIC PCR,SPORADIC BREAST-CANCER,HUMAN GENOME,COLORECTAL-CANCER,SOMATIC MUTATIONS,DNA METHYLATION,LUNG-CANCER,O-6-METHYLGUANINE-DNA METHYLTRANSFERASE,PROMOTER HYPERMETHYLATION,THERAPEUTIC VACCINATION},
  language     = {eng},
  number       = {1},
  pages        = {29--37},
  title        = {We are all individuals...: bioinformatics in the personalized medicine era},
  url          = {http://dx.doi.org/10.1007/s13402-014-0195-3},
  volume       = {38},
  year         = {2015},
}

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