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Cytokinin regulates root meristem activity via modulation of the polar auxin transport

Kamil Ruzicka UGent, Mária Braun Šimášková UGent, Jérôme Duclercq UGent, Jan Petrášek, Eva Zažímalová, Sibu Simon, Jiri Friml UGent, Marc Van Montagu UGent and Eva Benkova UGent (2009) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106(11). p.4284-4289
abstract
Plant development is governed by signaling molecules called phytohormones. Typically, in certain developmental processes more than 1 hormone is implicated and, thus, coordination of their overlapping activities is crucial for correct plant development. However, molecular mechanisms underlying the hormonal crosstalk are only poorly understood. Multiple hormones including cytokinin and auxin have been implicated in the regulation of root development. Here we dissect the roles of cytokinin in modulating growth of the primary root. We show that cytokinin effect on root elongation occurs through ethylene signaling whereas cytokinin effect on the root meristem size involves ethylene-independent modulation of transport-dependent asymmetric auxin distribution. Exogenous or endogenous modification of cytokinin levels and cytokinin signaling lead to specific changes in transcription of several auxin efflux carrier genes from the PIN family having a direct impact on auxin efflux from cultured cells and on auxin distribution in the root apex. We propose a novel model for cytokinin action in regulating root growth: Cytokinin influences cell-to-cell auxin transport by modification of expression of several auxin transport components and thus modulates auxin distribution important for regulation of activity and size of the root meristem.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
auxin transport, cytokinin, hormonal crosstalk, auxin, root meristem, CULTURED TOBACCO CELLS, ARABIDOPSIS-THALIANA, ETHYLENE BIOSYNTHESIS, EXPRESSION, PLANTS, EFFLUX, GROWTH, GENE, PIN, GRADIENTS
journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proc. Natl. Acad. Sci. USA
volume
106
issue
11
pages
4284 - 4289
Web of Science type
Article
Web of Science id
000264278800043
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
9.432 (2009)
JCR rank
3/48 (2009)
JCR quartile
1 (2009)
ISSN
0027-8424
DOI
10.1073/pnas.0900060106
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
592986
handle
http://hdl.handle.net/1854/LU-592986
date created
2009-04-09 17:14:16
date last changed
2012-12-04 16:17:22
@article{592986,
  abstract     = {Plant development is governed by signaling molecules called phytohormones. Typically, in certain developmental processes more than 1 hormone is implicated and, thus, coordination of their overlapping activities is crucial for correct plant development. However, molecular mechanisms underlying the hormonal crosstalk are only poorly understood. Multiple hormones including cytokinin and auxin have been implicated in the regulation of root development. Here we dissect the roles of cytokinin in modulating growth of the primary root. We show that cytokinin effect on root elongation occurs through ethylene signaling whereas cytokinin effect on the root meristem size involves ethylene-independent modulation of transport-dependent asymmetric auxin distribution. Exogenous or endogenous modification of cytokinin levels and cytokinin signaling lead to specific changes in transcription of several auxin efflux carrier genes from the PIN family having a direct impact on auxin efflux from cultured cells and on auxin distribution in the root apex. We propose a novel model for cytokinin action in regulating root growth: Cytokinin influences cell-to-cell auxin transport by modification of expression of several auxin transport components and thus modulates auxin distribution important for regulation of activity and size of the root meristem.},
  author       = {Ruzicka, Kamil and Braun \v{S}im{\'a}\v{s}kov{\'a}, M{\'a}ria and Duclercq, J{\'e}r{\^o}me and Petr{\'a}\v{s}ek, Jan and Za\v{z}{\'i}malov{\'a}, Eva and Simon, Sibu and Friml, Jiri and Van Montagu, Marc and Benkova, Eva},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {auxin transport,cytokinin,hormonal crosstalk,auxin,root meristem,CULTURED TOBACCO CELLS,ARABIDOPSIS-THALIANA,ETHYLENE BIOSYNTHESIS,EXPRESSION,PLANTS,EFFLUX,GROWTH,GENE,PIN,GRADIENTS},
  language     = {eng},
  number       = {11},
  pages        = {4284--4289},
  title        = {Cytokinin regulates root meristem activity via modulation of the polar auxin transport},
  url          = {http://dx.doi.org/10.1073/pnas.0900060106},
  volume       = {106},
  year         = {2009},
}

Chicago
Ruzicka, Kamil, Mária Šimášková, Jérôme Duclercq, Jan Petrášek, Eva Zažímalová, Sibu Simon, Jiri Friml, Marc Van Montagu, and Eva Benkova. 2009. “Cytokinin Regulates Root Meristem Activity via Modulation of the Polar Auxin Transport.” Proceedings of the National Academy of Sciences of the United States of America 106 (11): 4284–4289.
APA
Ruzicka, K., Šimášková, M., Duclercq, J., Petrášek, J., Zažímalová, E., Simon, S., Friml, J., et al. (2009). Cytokinin regulates root meristem activity via modulation of the polar auxin transport. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11), 4284–4289.
Vancouver
1.
Ruzicka K, Šimášková M, Duclercq J, Petrášek J, Zažímalová E, Simon S, et al. Cytokinin regulates root meristem activity via modulation of the polar auxin transport. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(11):4284–9.
MLA
Ruzicka, Kamil, Mária Šimášková, Jérôme Duclercq, et al. “Cytokinin Regulates Root Meristem Activity via Modulation of the Polar Auxin Transport.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.11 (2009): 4284–4289. Print.