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Assigning defined daily doses animal: a European multi-country experience for antimicrobial products authorized for usage in pigs

Merel Postma UGent, Marie Sjölund, Lucie Collineau, Svenja Lösken, Katharina DC Stärk and Jeroen Dewulf UGent (2015) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 70(1). p.294-302
abstract
Objectives: To establish a consensus defined daily dose animal (DDDA) for each active substance (AS) and administration route for porcine veterinary antimicrobial products authorized in four European countries, thus allowing cross-country quantification and comparison of antimicrobial usage data. Methods: All veterinary antimicrobial products authorized for porcine use in Belgium, France, Germany and Sweden were listed for each administration route. First, separate DDDAs for each product were defined based on the recommended dosing for the main indication. Second, a consensus DDDA was established by taking the mean of the DDDAs for each product within a certain category of AS plus administration route. Results: One-hundred-and-fifty-nine, 240, 281 and 50 antimicrobial products were licensed in Belgium, France, Germany and Sweden, respectively, in February 2013. Large variations were observed for dosage and treatment duration recommendations between products and between countries for the same ASs. Only 6.8% of feed/water and 29.4% of parenteral AS groups had the same recommended dosage in the four countries. Conclusions: This study presents a consensus DDDA list for use in the quantification and comparison of antimicrobial consumption. Four major recommendations have been formulated: (i) urgent need for harmonization of authorization and recommended summary of product characteristics (SPC) dosages; (ii) expand the developed preliminary DDDA list to include all authorized veterinary medicinal products in all EU member states and for all (food-producing) animal species; (iii) improved accessibility of country-specific SPC data would be preferable; and (iv) statement of the 'long-acting' duration of a product in the SPC.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cross-country comparison, antimicrobial usage quantification, defined course dose animal, defined daily dose animal, porcine antimicrobial products, ANTIBIOTIC CONSUMPTION
journal title
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
J. Antimicrob. Chemother.
volume
70
issue
1
pages
294 - 302
Web of Science type
Article
Web of Science id
000350210800040
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
4.919 (2015)
JCR rank
20/253 (2015)
JCR quartile
1 (2015)
ISSN
0305-7453
DOI
10.1093/jac/dku347
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5929477
handle
http://hdl.handle.net/1854/LU-5929477
date created
2015-04-09 11:53:59
date last changed
2016-12-19 15:39:32
@article{5929477,
  abstract     = {Objectives: To establish a consensus defined daily dose animal (DDDA) for each active substance (AS) and administration route for porcine veterinary antimicrobial products authorized in four European countries, thus allowing cross-country quantification and comparison of antimicrobial usage data. 
Methods: All veterinary antimicrobial products authorized for porcine use in Belgium, France, Germany and Sweden were listed for each administration route. First, separate DDDAs for each product were defined based on the recommended dosing for the main indication. Second, a consensus DDDA was established by taking the mean of the DDDAs for each product within a certain category of AS plus administration route. 
Results: One-hundred-and-fifty-nine, 240, 281 and 50 antimicrobial products were licensed in Belgium, France, Germany and Sweden, respectively, in February 2013. Large variations were observed for dosage and treatment duration recommendations between products and between countries for the same ASs. Only 6.8\% of feed/water and 29.4\% of parenteral AS groups had the same recommended dosage in the four countries. 
Conclusions: This study presents a consensus DDDA list for use in the quantification and comparison of antimicrobial consumption. Four major recommendations have been formulated: (i) urgent need for harmonization of authorization and recommended summary of product characteristics (SPC) dosages; (ii) expand the developed preliminary DDDA list to include all authorized veterinary medicinal products in all EU member states and for all (food-producing) animal species; (iii) improved accessibility of country-specific SPC data would be preferable; and (iv) statement of the 'long-acting' duration of a product in the SPC.},
  author       = {Postma, Merel and Sj{\"o}lund, Marie and Collineau, Lucie and L{\"o}sken, Svenja and St{\"a}rk, Katharina DC and Dewulf, Jeroen},
  issn         = {0305-7453},
  journal      = {JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY},
  keyword      = {cross-country comparison,antimicrobial usage quantification,defined course dose animal,defined daily dose animal,porcine antimicrobial products,ANTIBIOTIC CONSUMPTION},
  language     = {eng},
  number       = {1},
  pages        = {294--302},
  title        = {Assigning defined daily doses animal: a European multi-country experience for antimicrobial products authorized for usage in pigs},
  url          = {http://dx.doi.org/10.1093/jac/dku347},
  volume       = {70},
  year         = {2015},
}

Chicago
Postma, Merel, Marie Sjölund, Lucie Collineau, Svenja Lösken, Katharina DC Stärk, and Jeroen Dewulf. 2015. “Assigning Defined Daily Doses Animal: a European Multi-country Experience for Antimicrobial Products Authorized for Usage in Pigs.” Journal of Antimicrobial Chemotherapy 70 (1): 294–302.
APA
Postma, Merel, Sjölund, M., Collineau, L., Lösken, S., Stärk, K. D., & Dewulf, J. (2015). Assigning defined daily doses animal: a European multi-country experience for antimicrobial products authorized for usage in pigs. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(1), 294–302.
Vancouver
1.
Postma M, Sjölund M, Collineau L, Lösken S, Stärk KD, Dewulf J. Assigning defined daily doses animal: a European multi-country experience for antimicrobial products authorized for usage in pigs. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2015;70(1):294–302.
MLA
Postma, Merel, Marie Sjölund, Lucie Collineau, et al. “Assigning Defined Daily Doses Animal: a European Multi-country Experience for Antimicrobial Products Authorized for Usage in Pigs.” JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 70.1 (2015): 294–302. Print.