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Mathematical inference on helminth egg counts in stool and its applications in mass drug administration programmes to control soil-transmitted helminthiasis in public health

(2015) Advances in Parasitology. 87. p.193-247
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Abstract
In the present study, we present a hierarchical model based on faecal egg counts (FECs; expressed in eggs per 1g of stool) in which we first describe the variation in FECs between individuals in a particular population, followed by describing the variance due to counting eggs under a microscope separately for each stool sample. From this general framework, we discuss how to calculate a sample size for assessing a population mean FEC and the impact of an intervention, measured as reduction in FECs, for any scenario of soil-transmitted helminth (STH) epidemiology (the intensity and aggregation of FECs within a population) and diagnostic strategy (amount of stool examined (∼sensitivity of the diagnostic technique) and examination of individual/pooled stool samples) and on how to estimate prevalence of STH in the absence of a gold standard. To give these applications the most wide relevance as possible, we illustrate each of them with hypothetical examples.
Keywords
Soil-transmitted helminths, Survey design, True prevalence, Monitoring system, Anthelminthic resistance, Hierarchical model, Faecal egg counts, Mass drug administration, Sample size, SCHISTOSOMA-MANSONI, ASCARIS-LUMBRICOIDES, TREATMENT FAILURE, REDUCTION TEST, EFFICACY, INFECTIONS, HOOKWORM, CHEMOTHERAPY, DIAGNOSIS, FLOTAC

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Chicago
Levecke, Bruno, Roy M Anderson, Dirk Berkvens, Johannes Charlier, Brecht Devleesschauwer, Niko Speybroeck, Jozef Vercruysse, and Stefan Van Aelst. 2015. “Mathematical Inference on Helminth Egg Counts in Stool and Its Applications in Mass Drug Administration Programmes to Control Soil-transmitted Helminthiasis in Public Health.” Ed. Roy M Anderson and Maria Gloria Basáñez. Advances in Parasitology 87: 193–247.
APA
Levecke, B., Anderson, R. M., Berkvens, D., Charlier, J., Devleesschauwer, B., Speybroeck, N., Vercruysse, J., et al. (2015). Mathematical inference on helminth egg counts in stool and its applications in mass drug administration programmes to control soil-transmitted helminthiasis in public health. (R. M. Anderson & M. G. Basáñez, Eds.)Advances in Parasitology, 87, 193–247.
Vancouver
1.
Levecke B, Anderson RM, Berkvens D, Charlier J, Devleesschauwer B, Speybroeck N, et al. Mathematical inference on helminth egg counts in stool and its applications in mass drug administration programmes to control soil-transmitted helminthiasis in public health. Anderson RM, Basáñez MG, editors. Advances in Parasitology. San Diego, CA, USA: Elsevier Academic Press; 2015;87:193–247.
MLA
Levecke, Bruno, Roy M Anderson, Dirk Berkvens, et al. “Mathematical Inference on Helminth Egg Counts in Stool and Its Applications in Mass Drug Administration Programmes to Control Soil-transmitted Helminthiasis in Public Health.” Ed. Roy M Anderson & Maria Gloria Basáñez. Advances in Parasitology 87 (2015): 193–247. Print.
@article{5927682,
  abstract     = {In the present study, we present a hierarchical model based on faecal egg counts (FECs; expressed in eggs per 1g of stool) in which we first describe the variation in FECs between individuals in a particular population, followed by describing the variance due to counting eggs under a microscope separately for each stool sample. From this general framework, we discuss how to calculate a sample size for assessing a population mean FEC and the impact of an intervention, measured as reduction in FECs, for any scenario of soil-transmitted helminth (STH) epidemiology (the intensity and aggregation of FECs within a population) and diagnostic strategy (amount of stool examined (\ensuremath{\sim}sensitivity of the diagnostic technique) and examination of individual/pooled stool samples) and on how to estimate prevalence of STH in the absence of a gold standard. To give these applications the most wide relevance as possible, we illustrate each of them with hypothetical examples.},
  author       = {Levecke, Bruno and Anderson, Roy M and Berkvens, Dirk and Charlier, Johannes and Devleesschauwer, Brecht and Speybroeck, Niko and Vercruysse, Jozef and Van Aelst, Stefan},
  editor       = {Anderson, Roy M and Bas{\'a}{\~n}ez, Maria Gloria},
  isbn         = {9780128032565},
  issn         = {0065-308X},
  journal      = {Advances in Parasitology},
  language     = {eng},
  pages        = {193--247},
  publisher    = {Elsevier Academic Press},
  title        = {Mathematical inference on helminth egg counts in stool and its applications in mass drug administration programmes to control soil-transmitted helminthiasis in public health},
  url          = {http://dx.doi.org/10.1016/bs.apar.2015.01.001},
  volume       = {87},
  year         = {2015},
}

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