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Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer

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Abstract
Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells, and diverse immune cells. CAFs are recruited from local tissue-resident fibroblasts or pericryptal fibroblasts and distant fibroblast precursors. CAFs are highly abundant in CRC. In this review, we apply the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan andWeinberg. CAFs influence innate and adaptive tumor immune responses. Using datasets from previously published work, we re-explore the potential messages implicated in this process. Fibroblasts present in metastasis (metastasis-associated fibroblasts) from CRC may have other characteristics and functional roles than CAFs in the primary tumor. Since CAFs connect metastasis-promoting communication, CAF markers are potential prognostic biomarkers. CAFs and their products are possible targets for novel therapeutic strategies.
Keywords
cancer-associated fibroblasts, pericryptal fibroblasts, metastasis, colorectal cancer, immune cells

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Citation

Please use this url to cite or link to this publication:

Chicago
Tommelein, Joke, Laurine Verset, Tom Boterberg, Pieter Demetter, Marc Bracke, and Olivier De Wever. 2015. “Cancer-associated Fibroblasts Connect Metastasis-promoting Communication in Colorectal Cancer.” Frontiers in Oncology 5.
APA
Tommelein, J., Verset, L., Boterberg, T., Demetter, P., Bracke, M., & De Wever, O. (2015). Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer. FRONTIERS IN ONCOLOGY, 5.
Vancouver
1.
Tommelein J, Verset L, Boterberg T, Demetter P, Bracke M, De Wever O. Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer. FRONTIERS IN ONCOLOGY. 2015;5.
MLA
Tommelein, Joke, Laurine Verset, Tom Boterberg, et al. “Cancer-associated Fibroblasts Connect Metastasis-promoting Communication in Colorectal Cancer.” FRONTIERS IN ONCOLOGY 5 (2015): n. pag. Print.
@article{5923730,
  abstract     = {Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells, and diverse immune cells. CAFs are recruited from local tissue-resident fibroblasts or pericryptal fibroblasts and distant fibroblast precursors. CAFs are highly abundant in CRC. In this review, we apply the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan andWeinberg. CAFs influence innate and adaptive tumor immune responses.
Using datasets from previously published work, we re-explore the potential messages implicated in this process. Fibroblasts present in metastasis (metastasis-associated fibroblasts) from CRC may have other characteristics and functional roles than CAFs in the primary tumor. Since CAFs connect metastasis-promoting communication, CAF markers are potential prognostic biomarkers. CAFs and their products are possible targets for novel therapeutic strategies.},
  articleno    = {63},
  author       = {Tommelein, Joke and Verset, Laurine and Boterberg, Tom and Demetter, Pieter and Bracke, Marc and De Wever, Olivier},
  issn         = {2234-943X},
  journal      = {FRONTIERS IN ONCOLOGY},
  keyword      = {cancer-associated fibroblasts,pericryptal fibroblasts,metastasis,colorectal cancer,immune cells},
  language     = {eng},
  pages        = {11},
  title        = {Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer},
  url          = {http://dx.doi.org/10.3389/fonc.2015.00063},
  volume       = {5},
  year         = {2015},
}

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