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Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications

Jian Chen (UGent) , Sven Mangelinckx (UGent) , An Adams (UGent) , Zheng-tao Wang, Wei-lin Li and Norbert De Kimpe (UGent)
(2015) NATURAL PRODUCT COMMUNICATIONS. 10(1). p.187-200
Author
Organization
Project
01SF0209 Special Research Fund Joint PhD
Abstract
Diabetes mellitus, together with its various complications, is becoming a serious threat to human health. Natural products are secondary metabolites widely distributed in plants, having a broad range of biological activities. The development of antidiabetic medication from natural products, especially those originating from plants with a traceable folk-usage history in treating diabetes, is receiving more attention. Many studies highlighted not only the benefits of natural flavonoids with hypoglycemic effects, but also their importance in the management of diabetic complications. This review describes selected natural flavonoids that have been validated for their hypoglycemic properties, together with their mechanisms of action. Also discussed are their activities in the treatment of diabetic complications demonstrated via laboratory diabetic animal models, in vitro and clinical trials using human subjects. Published papers from 2000 to date on flavonoids and diabetes were covered through accessing Web of Science and multiple databases for biomedical sciences. The major potential benefits of natural fiavonoids discussed in this review clearly suggest that these substances are lead compounds with sufficient structural diversity of great importance in the antidiabetic drug developing process.
Keywords
Flavonoids, Diabetes, Diabetic complications, ALPHA-GLUCOSIDASE INHIBITORS, RAT SOLEUS MUSCLE, MC3T3-E1 OSTEOBLASTIC CELLS, PHOSPHATASE 1B INHIBITORS, INDUCED OXIDATIVE STRESS, PANCREATIC BETA-CELLS, RESISTANCE IN-VITRO, GREEN TEA CATECHIN, INSULIN-RESISTANCE, ANTIDIABETIC ACTIVITY

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Citation

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Chicago
Chen, Jian, Sven Mangelinckx, An Adams, Zheng-tao Wang, Wei-lin Li, and Norbert De Kimpe. 2015. “Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and Its Complications.” Natural Product Communications 10 (1): 187–200.
APA
Chen, Jian, Mangelinckx, S., Adams, A., Wang, Z., Li, W., & De Kimpe, N. (2015). Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications. NATURAL PRODUCT COMMUNICATIONS, 10(1), 187–200.
Vancouver
1.
Chen J, Mangelinckx S, Adams A, Wang Z, Li W, De Kimpe N. Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications. NATURAL PRODUCT COMMUNICATIONS. 2015;10(1):187–200.
MLA
Chen, Jian, Sven Mangelinckx, An Adams, et al. “Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and Its Complications.” NATURAL PRODUCT COMMUNICATIONS 10.1 (2015): 187–200. Print.
@article{5919387,
  abstract     = {Diabetes mellitus, together with its various complications, is becoming a serious threat to human health. Natural products are secondary metabolites widely distributed in plants, having a broad range of biological activities. The development of antidiabetic medication from natural products, especially those originating from plants with a traceable folk-usage history in treating diabetes, is receiving more attention. Many studies highlighted not only the benefits of natural flavonoids with hypoglycemic effects, but also their importance in the management of diabetic complications. This review describes selected natural flavonoids that have been validated for their hypoglycemic properties, together with their mechanisms of action. Also discussed are their activities in the treatment of diabetic complications demonstrated via laboratory diabetic animal models, in vitro and clinical trials using human subjects. Published papers from 2000 to date on flavonoids and diabetes were covered through accessing Web of Science and multiple databases for biomedical sciences. The major potential benefits of natural fiavonoids discussed in this review clearly suggest that these substances are lead compounds with sufficient structural diversity of great importance in the antidiabetic drug developing process.},
  author       = {Chen, Jian and Mangelinckx, Sven and Adams, An and Wang, Zheng-tao and Li, Wei-lin and De Kimpe, Norbert},
  issn         = {1934-578X},
  journal      = {NATURAL PRODUCT COMMUNICATIONS},
  keyword      = {Flavonoids,Diabetes,Diabetic complications,ALPHA-GLUCOSIDASE INHIBITORS,RAT SOLEUS MUSCLE,MC3T3-E1 OSTEOBLASTIC CELLS,PHOSPHATASE 1B INHIBITORS,INDUCED OXIDATIVE STRESS,PANCREATIC BETA-CELLS,RESISTANCE IN-VITRO,GREEN TEA CATECHIN,INSULIN-RESISTANCE,ANTIDIABETIC ACTIVITY},
  language     = {eng},
  number       = {1},
  pages        = {187--200},
  title        = {Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications},
  volume       = {10},
  year         = {2015},
}

Web of Science
Times cited: