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Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: a cross-sectional study in healthy male adolescents

SARA VANDEWALLE, Youri Taes, Tom Fiers, Kaatje Toye UGent, Eva Van Caenegem, I Roggen, Jean De Schepper UGent and Jean Kaufman UGent (2014) JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99(7). p.E1272-E1282
abstract
Background: Although both testosterone (T) and estradiol (E2) are considered essential in the regulation of the male skeleton, there are few data concerning the relative contribution of T and E2 on bone mineral density (BMD), bone geometry, and bone maturation in healthy boys. Objective: The objective of the study was to analyze the relationship between T and E2 and BMD, bone geometry, skeletal maturation, and body composition. Methods: This is a cross-sectional study in 199 healthy boys (aged 6-19 y). T and E2 were determined by liquid chromatography tandem mass spectrometry. Whole-body and lumbar areal bone mineral density (aBMD) and bone area, lean mass, and fat mass were determined by dual-energy X-ray absorptiometry. Trabecular (distal site) and cortical (proximal site) volumetric BMD (vBMD) and bone geometry were assessed at the nondominant forearm and leg using peripheral quantitative computed tomography. Skeletal age was determined by an X-ray of the left hand. Results: T was positively associated with lean mass (P < .001), lumbar and whole-body bone area (P < .001), trabecularandcortical area (P < .01), and periosteal circumference (P < .01) at the radius. E2 was positively associated with lumbar and whole-body a BMD(P < .001), trabecular vBMD at the radius and tibia (P < .01), and cortical thickness at the radius (P < .05). E2 was an independent negative predictor of the endosteal circumference (P < .01). Moreover, E2 was positively associated with bone age advancement (P < .001). Conclusion: Circulating E2 is positively associated with bone maturation and aBMD and vBMD and negatively with endosteal circumference in healthy boys, whereas T is a determinant of lean mass and bone size. These findings underscore the important role of E2 in skeletal development in boys.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DIFFERENT PUBERTAL STAGES, ESTROGEN-RECEPTOR-ALPHA, QUANTITATIVE COMPUTED-TOMOGRAPHY, PROXIMAL RADIUS, AROMATASE DEFICIENCY, ANDROGEN RECEPTOR, PHYSICAL-ACTIVITY, FREE TESTOSTERONE, GROWTH-PLATE, SIZE
journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
J. Clin. Endocrinol. Metab.
volume
99
issue
7
pages
E1272 - E1282
Web of Science type
Article
Web of Science id
000342341000014
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
6.209 (2014)
JCR rank
15/128 (2014)
JCR quartile
1 (2014)
ISSN
0021-972X
DOI
10.1210/jc.2013-3887
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5912819
handle
http://hdl.handle.net/1854/LU-5912819
date created
2015-03-25 14:52:18
date last changed
2016-12-19 15:39:30
@article{5912819,
  abstract     = {Background: Although both testosterone (T) and estradiol (E2) are considered essential in the regulation of the male skeleton, there are few data concerning the relative contribution of T and E2 on bone mineral density (BMD), bone geometry, and bone maturation in healthy boys. 
Objective: The objective of the study was to analyze the relationship between T and E2 and BMD, bone geometry, skeletal maturation, and body composition. 
Methods: This is a cross-sectional study in 199 healthy boys (aged 6-19 y). T and E2 were determined by liquid chromatography tandem mass spectrometry. Whole-body and lumbar areal bone mineral density (aBMD) and bone area, lean mass, and fat mass were determined by dual-energy X-ray absorptiometry. Trabecular (distal site) and cortical (proximal site) volumetric BMD (vBMD) and bone geometry were assessed at the nondominant forearm and leg using peripheral quantitative computed tomography. Skeletal age was determined by an X-ray of the left hand. 
Results: T was positively associated with lean mass (P {\textlangle} .001), lumbar and whole-body bone area (P {\textlangle} .001), trabecularandcortical area (P {\textlangle} .01), and periosteal circumference (P {\textlangle} .01) at the radius. E2 was positively associated with lumbar and whole-body a BMD(P {\textlangle} .001), trabecular vBMD at the radius and tibia (P {\textlangle} .01), and cortical thickness at the radius (P {\textlangle} .05). E2 was an independent negative predictor of the endosteal circumference (P {\textlangle} .01). Moreover, E2 was positively associated with bone age advancement (P {\textlangle} .001). 
Conclusion: Circulating E2 is positively associated with bone maturation and aBMD and vBMD and negatively with endosteal circumference in healthy boys, whereas T is a determinant of lean mass and bone size. These findings underscore the important role of E2 in skeletal development in boys.},
  author       = {VANDEWALLE, SARA and Taes, Youri and Fiers, Tom and Toye, Kaatje and Van Caenegem, Eva and Roggen, I and De Schepper, Jean and Kaufman, Jean},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {DIFFERENT PUBERTAL STAGES,ESTROGEN-RECEPTOR-ALPHA,QUANTITATIVE COMPUTED-TOMOGRAPHY,PROXIMAL RADIUS,AROMATASE DEFICIENCY,ANDROGEN RECEPTOR,PHYSICAL-ACTIVITY,FREE TESTOSTERONE,GROWTH-PLATE,SIZE},
  language     = {eng},
  number       = {7},
  pages        = {E1272--E1282},
  title        = {Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: a cross-sectional study in healthy male adolescents},
  url          = {http://dx.doi.org/10.1210/jc.2013-3887},
  volume       = {99},
  year         = {2014},
}

Chicago
Vandewalle, Sara, Youri Taes, TOM FIERS, Kaatje Toye, Eva Van Caenegem, I Roggen, Jean De Schepper, and Jean Kaufman. 2014. “Associations of Sex Steroids with Bone Maturation, Bone Mineral Density, Bone Geometry, and Body Composition: a Cross-sectional Study in Healthy Male Adolescents.” Journal of Clinical Endocrinology & Metabolism 99 (7): E1272–E1282.
APA
Vandewalle, Sara, Taes, Y., FIERS, T., Toye, K., Van Caenegem, E., Roggen, I., De Schepper, J., et al. (2014). Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: a cross-sectional study in healthy male adolescents. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 99(7), E1272–E1282.
Vancouver
1.
Vandewalle S, Taes Y, FIERS T, Toye K, Van Caenegem E, Roggen I, et al. Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: a cross-sectional study in healthy male adolescents. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(7):E1272–E1282.
MLA
Vandewalle, Sara, Youri Taes, TOM FIERS, et al. “Associations of Sex Steroids with Bone Maturation, Bone Mineral Density, Bone Geometry, and Body Composition: a Cross-sectional Study in Healthy Male Adolescents.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99.7 (2014): E1272–E1282. Print.