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The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

(2015) PLOS ONE. 10(3).
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Abstract
The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane (CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not only new insights on the possible role of the microbiome, but also further opportunities in cancer prevention and therapy by competing with these endogenous molecules and/or by modifying people’s life style.
Keywords
breast cancer, microbiome, peptides, Quorum sensing, EPITHELIAL-MESENCHYMAL TRANSITION, INTESTINAL-ABSORPTION, EXPRESSION, PERMEABILITY, MONOLAYERS, MICROBIOTA, MIGRATION, TRANSPORT, PROTEINS, KINETICS

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MLA
De Spiegeleer, Bart et al. “The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells in Vitro.” PLOS ONE 10.3 (2015): n. pag. Print.
APA
De Spiegeleer, B., Verbeke, F., D’Hondt, M., Hendrix, A., Van De Wiele, C., Burvenich, C., Peremans, K., et al. (2015). The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro. PLOS ONE, 10(3).
Chicago author-date
De Spiegeleer, Bart, Frederick Verbeke, Matthias D’Hondt, An Hendrix, Christophe Van De Wiele, Christian Burvenich, Kathelijne Peremans, Olivier De Wever, Marc Bracke, and Evelien Wynendaele. 2015. “The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells in Vitro.” Plos One 10 (3).
Chicago author-date (all authors)
De Spiegeleer, Bart, Frederick Verbeke, Matthias D’Hondt, An Hendrix, Christophe Van De Wiele, Christian Burvenich, Kathelijne Peremans, Olivier De Wever, Marc Bracke, and Evelien Wynendaele. 2015. “The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells in Vitro.” Plos One 10 (3).
Vancouver
1.
De Spiegeleer B, Verbeke F, D’Hondt M, Hendrix A, Van De Wiele C, Burvenich C, et al. The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro. PLOS ONE. 2015;10(3).
IEEE
[1]
B. De Spiegeleer et al., “The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro,” PLOS ONE, vol. 10, no. 3, 2015.
@article{5910262,
  abstract     = {The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane (CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not only new insights on the possible role of the microbiome, but also further opportunities in cancer prevention and therapy by competing with these endogenous molecules and/or by modifying people’s life style.},
  articleno    = {e0119471},
  author       = {De Spiegeleer, Bart and Verbeke, Frederick and D'Hondt, Matthias and Hendrix, An and Van De Wiele, Christophe and Burvenich, Christian and Peremans, Kathelijne and De Wever, Olivier and Bracke, Marc and Wynendaele, Evelien},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {breast cancer,microbiome,peptides,Quorum sensing,EPITHELIAL-MESENCHYMAL TRANSITION,INTESTINAL-ABSORPTION,EXPRESSION,PERMEABILITY,MONOLAYERS,MICROBIOTA,MIGRATION,TRANSPORT,PROTEINS,KINETICS},
  language     = {eng},
  number       = {3},
  pages        = {14},
  title        = {The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro},
  url          = {http://dx.doi.org/10.1371/journal.pone.0119471},
  volume       = {10},
  year         = {2015},
}

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