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TNFA-3086 > A in two international population-based cohorts and risk of asthma

(2008) EUROPEAN RESPIRATORY JOURNAL. 32(2). p.350-361
Author
Organization
Abstract
Genetic association studies have related the tumour necrosis factor-a gene (TNFA) guanine to adenine substitution of nucleotide -308 (-3086 > A) polymorphism to increased risk of asthma, but results are inconsistent. The aim of the present study was to test whether two single-nucleotide polymorphisms, of TNFA and of the lymphotoxin-alpha gene (LTA), are associated with asthma, bronchial hyperresponsiveness and atopy in adults, by combining the results of two large population-based multicentric studies and conducting a meta-analysis of previously published studies. The European Community Respiratory Health Survey (ECRHS) and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) used comparable protocols, including questionnaires for respiratory symptoms and measures of lung function and atopy. DNA samples from 11,136 participants were genotyped at TNFA -308 and LTA 252. Logistic regression employing fixed and random effects models and nonparametric techniques were used. The prevalence of asthma was 6%. The TNFA -3086 > A polymorphism was associated with increased asthma prevalence and with bronchial hyperresponsiveness. No consistent association was found for atopy. The LTA 252A > G polymorphism was not associated with any of the outcomes. A meta-analysis of 17 studies showed an increased asthma risk for the TNFA -308 adenine allele. The tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy. These results are supported by a meta-analysis of previously published studies.
Keywords
NECROSIS-FACTOR-ALPHA, MULTIFACTOR-DIMENSIONALITY REDUCTION, GENE-ENVIRONMENT INTERACTIONS, RESPIRATORY-HEALTH-SURVEY, BODY-MASS INDEX, TNF-ALPHA, CHILDHOOD ASTHMA, ATOPIC ASTHMA, BRONCHIAL RESPONSIVENESS, PROMOTER POLYMORPHISM, asthma, genetics, lymphotoxin-alpha, polymorphism, tumour necrosis factor

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MLA
Castro-Giner, F., et al. “TNFA-3086 > A in Two International Population-Based Cohorts and Risk of Asthma.” EUROPEAN RESPIRATORY JOURNAL, vol. 32, no. 2, 2008, pp. 350–61.
APA
Castro-Giner, F., Kogevinas, M., Machler, M., de Cid, R., Van Steen, K., Imboden, M., … Probst-Hensch, N. (2008). TNFA-3086 > A in two international population-based cohorts and risk of asthma. EUROPEAN RESPIRATORY JOURNAL, 32(2), 350–361.
Chicago author-date
Castro-Giner, F, M Kogevinas, M Machler, R de Cid, Kristel Van Steen, M Imboden, C Schindler, et al. 2008. “TNFA-3086 > A in Two International Population-Based Cohorts and Risk of Asthma.” EUROPEAN RESPIRATORY JOURNAL 32 (2): 350–61.
Chicago author-date (all authors)
Castro-Giner, F, M Kogevinas, M Machler, R de Cid, Kristel Van Steen, M Imboden, C Schindler, W Berger, JR Gonzalez, KA Franklin, C Janson, D Jarvis, I Omenaas, R Burney, T Rochat, X Estivill, JM Anto, M Wjst, and NM Probst-Hensch. 2008. “TNFA-3086 > A in Two International Population-Based Cohorts and Risk of Asthma.” EUROPEAN RESPIRATORY JOURNAL 32 (2): 350–361.
Vancouver
1.
Castro-Giner F, Kogevinas M, Machler M, de Cid R, Van Steen K, Imboden M, et al. TNFA-3086 > A in two international population-based cohorts and risk of asthma. EUROPEAN RESPIRATORY JOURNAL. 2008;32(2):350–61.
IEEE
[1]
F. Castro-Giner et al., “TNFA-3086 > A in two international population-based cohorts and risk of asthma,” EUROPEAN RESPIRATORY JOURNAL, vol. 32, no. 2, pp. 350–361, 2008.
@article{5907228,
  abstract     = {Genetic association studies have related the tumour necrosis factor-a gene (TNFA) guanine to adenine substitution of nucleotide -308 (-3086 > A) polymorphism to increased risk of asthma, but results are inconsistent. The aim of the present study was to test whether two single-nucleotide polymorphisms, of TNFA and of the lymphotoxin-alpha gene (LTA), are associated with asthma, bronchial hyperresponsiveness and atopy in adults, by combining the results of two large population-based multicentric studies and conducting a meta-analysis of previously published studies. The European Community Respiratory Health Survey (ECRHS) and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) used comparable protocols, including questionnaires for respiratory symptoms and measures of lung function and atopy. DNA samples from 11,136 participants were genotyped at TNFA -308 and LTA 252. Logistic regression employing fixed and random effects models and nonparametric techniques were used. The prevalence of asthma was 6%. The TNFA -3086 > A polymorphism was associated with increased asthma prevalence and with bronchial hyperresponsiveness. No consistent association was found for atopy. The LTA 252A > G polymorphism was not associated with any of the outcomes. A meta-analysis of 17 studies showed an increased asthma risk for the TNFA -308 adenine allele. The tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy. These results are supported by a meta-analysis of previously published studies.},
  author       = {Castro-Giner, F and Kogevinas, M and Machler, M and de Cid, R and Van Steen, Kristel and Imboden, M and Schindler, C and Berger, W and Gonzalez, JR and Franklin, KA and Janson, C and Jarvis, D and Omenaas, I and Burney, R and Rochat, T and Estivill, X and Anto, JM and Wjst, M and Probst-Hensch, NM},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keywords     = {NECROSIS-FACTOR-ALPHA,MULTIFACTOR-DIMENSIONALITY REDUCTION,GENE-ENVIRONMENT INTERACTIONS,RESPIRATORY-HEALTH-SURVEY,BODY-MASS INDEX,TNF-ALPHA,CHILDHOOD ASTHMA,ATOPIC ASTHMA,BRONCHIAL RESPONSIVENESS,PROMOTER POLYMORPHISM,asthma,genetics,lymphotoxin-alpha,polymorphism,tumour necrosis factor},
  language     = {eng},
  number       = {2},
  pages        = {350--361},
  title        = {TNFA-3086 > A in two international population-based cohorts and risk of asthma},
  url          = {http://dx.doi.org/10.1183/09031936.00155607},
  volume       = {32},
  year         = {2008},
}

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