@article{5905984,
  abstract     = {{Objective: To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6-10 years. 
Design: Pooled analysis of individual participant data of 11 prospective European birth cohorts that recruited a total of over 22,000 children in the 1990s. 
Exposure definition: Ownership of only cats, dogs, birds, rodents, or cats/dogs combined during the first 2 years of life. 
Outcome definition: Current asthma (primary outcome), allergic asthma, allergic rhinitis and allergic sensitization during 610 years of age. 
Data synthesis: Three-step approach: (i) Common definition of outcome and exposure variables across cohorts; (ii) calculation of adjusted effect estimates for each cohort; (iii) pooling of effect estimates by using random effects meta-analysis models. 
Results: We found no association between furry and feathered pet keeping early in life and asthma in school age. For example, the odds ratio for asthma comparing cat ownership with "no pets" (10 studies, 11489 participants) was 1.00 (95% confidence interval 0.78 to 1.28) (I 2 = 9%; p = 0.36). The odds ratio for asthma comparing dog ownership with "no pets" (9 studies, 11433 participants) was 0.77 (0.58 to 1.03) (I-2 = 0%, p = 0.89). Owning both cat(s) and dog(s) compared to "no pets" resulted in an odds ratio of 1.04 (0.59 to 1.84) (I-2 = 33%, p = 0.18). Similarly, for allergic asthma and for allergic rhinitis we did not find associations regarding any type of pet ownership early in life. However, we found some evidence for an association between ownership of furry pets during the first 2 years of life and reduced likelihood of becoming sensitized to aero-allergens. 
Conclusions: Pet ownership in early life did not appear to either increase or reduce the risk of asthma or allergic rhinitis symptoms in children aged 6-10. Advice from health care practitioners to avoid or to specifically acquire pets for primary prevention of asthma or allergic rhinitis in children should not be given.}},
  articleno    = {{e43214}},
  author       = {{Carlsen, Karin C Lodrup and Roll, Stephanie and Carlsen, Kai-Hakon and Mowinckel, Petter and Wijga, Alet H and Brunekreef, Bert and Torrent, Maties and Roberts, Graham and Arshad, S Hasan and Kull, Inger and Kramer, Ursula and von Berg, Andrea and Eller, Esben and Host, Arne and Kuehni, Claudia and Spycher, Ben and Sunyer, Jordi and Chen, Chih-Mei and Reich, Andreas and Asarnoj, Anna and Puig, Carmen and Herbarth, Olf and John, Jestinah M Mahachie and Van Steen, Kristel and Willich, Stefan N and Wahn, Ulrich and Lau, Susanne and Keil, Thomas}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  keywords     = {{DOG OWNERSHIP,CAT ALLERGEN,PROPENSITY SCORE,ATOPIC DISEASES,EARLY EXPOSURE,SENSITIZATION,CHILDHOOD,RISK,SYMPTOMS,COMMUNITY}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{12}},
  title        = {{Does pet ownership in infancy lead to asthma or allergy at school age? : pooled analysis of individual participant data from 11 European birth cohorts}},
  url          = {{http://doi.org/10.1371/journal.pone.0043214}},
  volume       = {{7}},
  year         = {{2012}},
}

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