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A versatile and experimentally validated finite element model to assess the accuracy of shear wave elastography in a bounded viscoelastic medium

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Abstract
The feasibility of shear wave elastography (SWE) in arteries for cardiovascular risk assessment remains to be investigated as the artery's thin wall and intricate material properties induce complex shear wave (SW) propagation phenomena. To better understand the SW physics in bounded media, we proposed an in vitro validated finite element model capable of simulating SW propagation, with full flexibility at the level of the tissue's geometry, material properties, and acoustic radiation force. This computer model was presented in a relatively basic set-up, a homogeneous slab of gelatin-agar material (4.35 mm thick), allowing validation of the numerical settings according to actual SWE measurements. The resulting tissue velocity waveforms and SW propagation speed matched well with the measurement: 4.46 m/s (simulation) versus 4.63 +/- 0.07 m/s (experiment). Further, we identified the impact of geometrical and material parameters on the SW propagation characteristics. As expected, phantom thickness was a determining factor of dispersion. Adding viscoelasticity to the model augmented the estimated wave speed to 4.58 m/s, an even better match with the experimental determined value. This study demonstrated that finite element modeling can be a powerful tool to gain insight into SWE mechanics and will in future work be advanced to more clinically relevant settings.
Keywords
ACOUSTIC RADIATION FORCE, LIVER FIBROSIS, ELASTICITY, TISSUES, QUANTIFICATION, SPECTROSCOPY, TECHNOLOGY, EXCITATION, FIELD

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Chicago
Caenen, Annette, Darya Shcherbakova, Benedict Verhegghe, Clement Papadacci, Mathieu Pernot, Patrick Segers, and Abigaïl Swillens. 2015. “A Versatile and Experimentally Validated Finite Element Model to Assess the Accuracy of Shear Wave Elastography in a Bounded Viscoelastic Medium.” Ieee Transactions on Ultrasonics Ferroelectrics and Frequency Control 62 (3): 439–450.
APA
Caenen, A., Shcherbakova, D., Verhegghe, B., Papadacci, C., Pernot, M., Segers, P., & Swillens, A. (2015). A versatile and experimentally validated finite element model to assess the accuracy of shear wave elastography in a bounded viscoelastic medium. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(3), 439–450.
Vancouver
1.
Caenen A, Shcherbakova D, Verhegghe B, Papadacci C, Pernot M, Segers P, et al. A versatile and experimentally validated finite element model to assess the accuracy of shear wave elastography in a bounded viscoelastic medium. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL. 2015;62(3):439–50.
MLA
Caenen, Annette, Darya Shcherbakova, Benedict Verhegghe, et al. “A Versatile and Experimentally Validated Finite Element Model to Assess the Accuracy of Shear Wave Elastography in a Bounded Viscoelastic Medium.” IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL 62.3 (2015): 439–450. Print.
@article{5889429,
  abstract     = {The feasibility of shear wave elastography (SWE) in arteries for cardiovascular risk assessment remains to be investigated as the artery's thin wall and intricate material properties induce complex shear wave (SW) propagation phenomena. To better understand the SW physics in bounded media, we proposed an in vitro validated finite element model capable of simulating SW propagation, with full flexibility at the level of the tissue's geometry, material properties, and acoustic radiation force. This computer model was presented in a relatively basic set-up, a homogeneous slab of gelatin-agar material (4.35 mm thick), allowing validation of the numerical settings according to actual SWE measurements. The resulting tissue velocity waveforms and SW propagation speed matched well with the measurement: 4.46 m/s (simulation) versus 4.63 +/- 0.07 m/s (experiment). Further, we identified the impact of geometrical and material parameters on the SW propagation characteristics. As expected, phantom thickness was a determining factor of dispersion. Adding viscoelasticity to the model augmented the estimated wave speed to 4.58 m/s, an even better match with the experimental determined value. This study demonstrated that finite element modeling can be a powerful tool to gain insight into SWE mechanics and will in future work be advanced to more clinically relevant settings.},
  author       = {Caenen, Annette and Shcherbakova, Darya and Verhegghe, Benedict and Papadacci, Clement and Pernot, Mathieu and Segers, Patrick and Swillens, Abiga{\"i}l},
  issn         = {0885-3010},
  journal      = {IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL},
  keyword      = {ACOUSTIC RADIATION FORCE,LIVER FIBROSIS,ELASTICITY,TISSUES,QUANTIFICATION,SPECTROSCOPY,TECHNOLOGY,EXCITATION,FIELD},
  language     = {eng},
  number       = {3},
  pages        = {439--450},
  title        = {A versatile and experimentally validated finite element model to assess the accuracy of shear wave elastography in a bounded viscoelastic medium},
  url          = {http://dx.doi.org/10.1109/TUFFC.2014.006682},
  volume       = {62},
  year         = {2015},
}

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