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Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

(2014) CLINICAL INFECTIOUS DISEASES. 59(4). p.596-600
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Abstract
The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.
Keywords
coreceptor, stem cell transplantation, Berlin-Patient, cure, HIV, MARAVIROC, VIRUSES, USAGE, V3 LOOP, TROPISM

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Citation

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Chicago
Symons, Jori, Linos Vandekerckhove, Gero Hutter, Annemarie MJ Wensing, Petra M van Ham, Steven G Deeks, and Monique Nijhuis. 2014. “Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-predicted HIV Variants in the Berlin Patient.” Clinical Infectious Diseases 59 (4): 596–600.
APA
Symons, Jori, Vandekerckhove, L., Hutter, G., Wensing, A. M., van Ham, P. M., Deeks, S. G., & Nijhuis, M. (2014). Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient. CLINICAL INFECTIOUS DISEASES, 59(4), 596–600.
Vancouver
1.
Symons J, Vandekerckhove L, Hutter G, Wensing AM, van Ham PM, Deeks SG, et al. Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient. CLINICAL INFECTIOUS DISEASES. 2014;59(4):596–600.
MLA
Symons, Jori, Linos Vandekerckhove, Gero Hutter, et al. “Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-predicted HIV Variants in the Berlin Patient.” CLINICAL INFECTIOUS DISEASES 59.4 (2014): 596–600. Print.
@article{5866506,
  abstract     = {The {\textacutedbl}Berlin patient{\textacutedbl} is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.},
  author       = {Symons, Jori and Vandekerckhove, Linos and Hutter, Gero and Wensing, Annemarie MJ and van Ham, Petra M and Deeks, Steven G and Nijhuis, Monique},
  issn         = {1058-4838},
  journal      = {CLINICAL INFECTIOUS DISEASES},
  keyword      = {coreceptor,stem cell transplantation,Berlin-Patient,cure,HIV,MARAVIROC,VIRUSES,USAGE,V3 LOOP,TROPISM},
  language     = {eng},
  number       = {4},
  pages        = {596--600},
  title        = {Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient},
  url          = {http://dx.doi.org/10.1093/cid/ciu284},
  volume       = {59},
  year         = {2014},
}

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