Ghent University Academic Bibliography

Advanced

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

Jori Symons, Linos Vandekerckhove UGent, Gero Hutter, Annemarie MJ Wensing, Petra M van Ham, Steven G Deeks and Monique Nijhuis (2014) CLINICAL INFECTIOUS DISEASES. 59(4). p.596-600
abstract
The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
coreceptor, stem cell transplantation, Berlin-Patient, cure, HIV, MARAVIROC, VIRUSES, USAGE, V3 LOOP, TROPISM
journal title
CLINICAL INFECTIOUS DISEASES
Clin. Infect. Dis.
volume
59
issue
4
pages
596 - 600
Web of Science type
Article
Web of Science id
000342921400027
JCR category
INFECTIOUS DISEASES
JCR impact factor
8.886 (2014)
JCR rank
2/78 (2014)
JCR quartile
1 (2014)
ISSN
1058-4838
DOI
10.1093/cid/ciu284
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5866506
handle
http://hdl.handle.net/1854/LU-5866506
date created
2015-02-26 10:43:42
date last changed
2016-12-19 15:46:41
@article{5866506,
  abstract     = {The {\textacutedbl}Berlin patient{\textacutedbl} is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.},
  author       = {Symons, Jori and Vandekerckhove, Linos and Hutter, Gero and Wensing, Annemarie MJ and van Ham, Petra M and Deeks, Steven G and Nijhuis, Monique},
  issn         = {1058-4838},
  journal      = {CLINICAL INFECTIOUS DISEASES},
  keyword      = {coreceptor,stem cell transplantation,Berlin-Patient,cure,HIV,MARAVIROC,VIRUSES,USAGE,V3 LOOP,TROPISM},
  language     = {eng},
  number       = {4},
  pages        = {596--600},
  title        = {Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient},
  url          = {http://dx.doi.org/10.1093/cid/ciu284},
  volume       = {59},
  year         = {2014},
}

Chicago
Symons, Jori, Linos Vandekerckhove, Gero Hutter, Annemarie MJ Wensing, Petra M van Ham, Steven G Deeks, and Monique Nijhuis. 2014. “Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-predicted HIV Variants in the Berlin Patient.” Clinical Infectious Diseases 59 (4): 596–600.
APA
Symons, Jori, Vandekerckhove, L., Hutter, G., Wensing, A. M., van Ham, P. M., Deeks, S. G., & Nijhuis, M. (2014). Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient. CLINICAL INFECTIOUS DISEASES, 59(4), 596–600.
Vancouver
1.
Symons J, Vandekerckhove L, Hutter G, Wensing AM, van Ham PM, Deeks SG, et al. Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient. CLINICAL INFECTIOUS DISEASES. 2014;59(4):596–600.
MLA
Symons, Jori, Linos Vandekerckhove, Gero Hutter, et al. “Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-predicted HIV Variants in the Berlin Patient.” CLINICAL INFECTIOUS DISEASES 59.4 (2014): 596–600. Print.