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Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma

Woo-Jung Song, Yoon-Seok Chang, Min Kyung Lim, E Hwa Yun, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, PETER TOMASSEN, Min-Ho Choi, Kyung-Up Min, et al. (2014) CLINICAL AND EXPERIMENTAL ALLERGY. 44(4). p.553-562
abstract
Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age=60.2years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. Results: Staphylococcal enterotoxin sensitization (0.35kU/L) had a prevalence of 27.0%. Risk factors were identified as male sex, current smoking, advanced age (61years), and inhalant allergen sensitization. Current asthma was mostly adult onset (18years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
epidemiology, immunoglobulin E, asthma, Staphylococcus aureus, IGE ANTIBODIES, SERUM IGE, CHRONIC RHINOSINUSITIS, AUREUS ENTEROTOXINS, GENERAL-POPULATION, ALLERGIC RHINITIS, ATOPIC-DERMATITIS, DETERMINANTS, ASSOCIATION, DISEASE
journal title
CLINICAL AND EXPERIMENTAL ALLERGY
Clin. Exp. Allergy
volume
44
issue
4
pages
553 - 562
Web of Science type
Article
Web of Science id
000333334000011
JCR category
ALLERGY
JCR impact factor
4.769 (2014)
JCR rank
4/24 (2014)
JCR quartile
1 (2014)
ISSN
0954-7894
DOI
10.1111/cea.12239
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5860930
handle
http://hdl.handle.net/1854/LU-5860930
date created
2015-02-23 09:36:04
date last changed
2017-10-11 11:19:48
@article{5860930,
  abstract     = {Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. 
Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. 
Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age=60.2years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. 
Results: Staphylococcal enterotoxin sensitization (0.35kU/L) had a prevalence of 27.0\%. Risk factors were identified as male sex, current smoking, advanced age (61years), and inhalant allergen sensitization. Current asthma was mostly adult onset (18years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. 
Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.},
  author       = {Song, Woo-Jung and Chang, Yoon-Seok and Lim, Min Kyung and Yun, E Hwa and Kim, Sae-Hoon and Kang, Hye-Ryun and Park, Heung-Woo and TOMASSEN, PETER and Choi, Min-Ho and Min, Kyung-Up and Cho, Sang-Heon and Bachert, Claus},
  issn         = {0954-7894},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  keyword      = {epidemiology,immunoglobulin E,asthma,Staphylococcus aureus,IGE ANTIBODIES,SERUM IGE,CHRONIC RHINOSINUSITIS,AUREUS ENTEROTOXINS,GENERAL-POPULATION,ALLERGIC RHINITIS,ATOPIC-DERMATITIS,DETERMINANTS,ASSOCIATION,DISEASE},
  language     = {eng},
  number       = {4},
  pages        = {553--562},
  title        = {Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma},
  url          = {http://dx.doi.org/10.1111/cea.12239},
  volume       = {44},
  year         = {2014},
}

Chicago
Song, Woo-Jung, Yoon-Seok Chang, Min Kyung Lim, E Hwa Yun, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, et al. 2014. “Staphylococcal Enterotoxin Sensitization in a Community-based Population : a Potential Role in Adult-onset Asthma.” Clinical and Experimental Allergy 44 (4): 553–562.
APA
Song, Woo-Jung, Chang, Y.-S., Lim, M. K., Yun, E. H., Kim, S.-H., Kang, H.-R., Park, H.-W., et al. (2014). Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 44(4), 553–562.
Vancouver
1.
Song W-J, Chang Y-S, Lim MK, Yun EH, Kim S-H, Kang H-R, et al. Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma. CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(4):553–62.
MLA
Song, Woo-Jung, Yoon-Seok Chang, Min Kyung Lim, et al. “Staphylococcal Enterotoxin Sensitization in a Community-based Population : a Potential Role in Adult-onset Asthma.” CLINICAL AND EXPERIMENTAL ALLERGY 44.4 (2014): 553–562. Print.