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Early origins of chronic obstructive lung diseases across the life course

(2014) EUROPEAN JOURNAL OF EPIDEMIOLOGY. 29(12). p.871-885
Author
Organization
Abstract
Chronic obstructive lung diseases, like asthma and chronic obstructive pulmonary disease, have high prevalences and are a major public health concern. Chronic obstructive lung diseases have at least part of their origins in early life. Exposure to an adverse environment during critical periods in early life might lead to permanent developmental adaptations which results in impaired lung growth with smaller airways and lower lung volume, altered immunological responses and related inflammation, and subsequently to increased risks of chronic obstructive lung diseases throughout the life course. Various pathways leading from early life factors to respiratory health outcomes in later life have been studied, including fetal and early infant growth patterns, preterm birth, maternal obesity, diet and smoking, children's diet, allergen exposure and respiratory tract infections, and genetic susceptibility. Data on potential adverse factors in the embryonic and preconception period and respiratory health outcomes are scarce. Also, the underlying mechanisms how specific adverse exposures in the fetal and early postnatal period lead to chronic obstructive lung diseases in later life are not yet fully understood. Current studies suggest that interactions between early environmental exposures and genetic factors such as changes in DNA-methylation and RNA expression patterns may explain the early development of chronic obstructive lung diseases. New well-designed epidemiological studies are needed to identify specific critical periods and to elucidate the mechanisms underlying the development of chronic obstructive lung disease throughout the life course.
Keywords
GENOME-WIDE ASSOCIATION, Early origins, Asthma, Child, Cohort study, Chronic Obstructive Pulmonary Disease (COPD), RESPIRATORY SYNCYTIAL VIRUS, PROSPECTIVE BIRTH COHORT, GESTATIONAL WEIGHT-GAIN, TOBACCO-SMOKE EXPOSURE, SCHOOL-AGE-CHILDREN, BODY-MASS INDEX, POLYUNSATURATED FATTY-ACIDS, SOUTHAMPTON WOMENS SURVEY, EXTREMELY PRETERM INFANTS

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Citation

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MLA
Duijts, Liesbeth, Irwin K Reiss, Guy Brusselle, et al. “Early Origins of Chronic Obstructive Lung Diseases Across the Life Course.” EUROPEAN JOURNAL OF EPIDEMIOLOGY 29.12 (2014): 871–885. Print.
APA
Duijts, L., Reiss, I. K., Brusselle, G., & de Jongste, J. C. (2014). Early origins of chronic obstructive lung diseases across the life course. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 29(12), 871–885.
Chicago author-date
Duijts, Liesbeth, Irwin K Reiss, Guy Brusselle, and Johan C de Jongste. 2014. “Early Origins of Chronic Obstructive Lung Diseases Across the Life Course.” European Journal of Epidemiology 29 (12): 871–885.
Chicago author-date (all authors)
Duijts, Liesbeth, Irwin K Reiss, Guy Brusselle, and Johan C de Jongste. 2014. “Early Origins of Chronic Obstructive Lung Diseases Across the Life Course.” European Journal of Epidemiology 29 (12): 871–885.
Vancouver
1.
Duijts L, Reiss IK, Brusselle G, de Jongste JC. Early origins of chronic obstructive lung diseases across the life course. EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2014;29(12):871–85.
IEEE
[1]
L. Duijts, I. K. Reiss, G. Brusselle, and J. C. de Jongste, “Early origins of chronic obstructive lung diseases across the life course,” EUROPEAN JOURNAL OF EPIDEMIOLOGY, vol. 29, no. 12, pp. 871–885, 2014.
@article{5847731,
  abstract     = {Chronic obstructive lung diseases, like asthma and chronic obstructive pulmonary disease, have high prevalences and are a major public health concern. Chronic obstructive lung diseases have at least part of their origins in early life. Exposure to an adverse environment during critical periods in early life might lead to permanent developmental adaptations which results in impaired lung growth with smaller airways and lower lung volume, altered immunological responses and related inflammation, and subsequently to increased risks of chronic obstructive lung diseases throughout the life course. Various pathways leading from early life factors to respiratory health outcomes in later life have been studied, including fetal and early infant growth patterns, preterm birth, maternal obesity, diet and smoking, children's diet, allergen exposure and respiratory tract infections, and genetic susceptibility. Data on potential adverse factors in the embryonic and preconception period and respiratory health outcomes are scarce. Also, the underlying mechanisms how specific adverse exposures in the fetal and early postnatal period lead to chronic obstructive lung diseases in later life are not yet fully understood. Current studies suggest that interactions between early environmental exposures and genetic factors such as changes in DNA-methylation and RNA expression patterns may explain the early development of chronic obstructive lung diseases. New well-designed epidemiological studies are needed to identify specific critical periods and to elucidate the mechanisms underlying the development of chronic obstructive lung disease throughout the life course.},
  author       = {Duijts, Liesbeth and Reiss, Irwin K and Brusselle, Guy and de Jongste, Johan C},
  issn         = {0393-2990},
  journal      = {EUROPEAN JOURNAL OF EPIDEMIOLOGY},
  keywords     = {GENOME-WIDE ASSOCIATION,Early origins,Asthma,Child,Cohort study,Chronic Obstructive Pulmonary Disease (COPD),RESPIRATORY SYNCYTIAL VIRUS,PROSPECTIVE BIRTH COHORT,GESTATIONAL WEIGHT-GAIN,TOBACCO-SMOKE EXPOSURE,SCHOOL-AGE-CHILDREN,BODY-MASS INDEX,POLYUNSATURATED FATTY-ACIDS,SOUTHAMPTON WOMENS SURVEY,EXTREMELY PRETERM INFANTS},
  language     = {eng},
  number       = {12},
  pages        = {871--885},
  title        = {Early origins of chronic obstructive lung diseases across the life course},
  url          = {http://dx.doi.org/10.1007/s10654-014-9981-5},
  volume       = {29},
  year         = {2014},
}

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