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Novel biocompatible nanocapsules for slow release of fragrances on the human skin

(2015) NEW BIOTECHNOLOGY. 32(1). p.40-46
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Abstract
There is a growing demand for fragranced products, but due to the poor aqueous solubility and instability of fragrance molecules, their use is limited. Nowadays, fragrance encapsulation in biocompatible nanocontainer material is emerging as a novel strategy to overcome the evaporation of volatile molecules and to prolong the sensory characteristics of fragrance molecules and the longevity of perfumes. The objective of this study was to develop an innovative sustained release system of perfume, by entrapping fragrance molecules in a polymeric nanocarrier; the impact of this strategy on the human axillary microbiome was further assessed. Stabilised poly-L-lactic acid nanocapsules (PLA-NCs) with a diameter of approximately 115 nm were prepared through nanoprecipitation. Size and morphology of the capsules were evaluated using Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). Two model hydrophobic compounds, chlorobenzene and fluorescein, representing two different types of functionalised molecules, were encapsulated in PLA-NCs with an efficiency rate of 50%. Different release behaviours were seen, dependent on hydrophobicity. For hydrophobic compounds, a steady release was observed over 48 hours. The polymeric nanocarriers did not impact the human axillary microbiome. Because of the slow and sustained release of fragrances, encapsulation of molecules in biocompatible NCs can represent a revolutionary contribution to the future of toiletries, body deodorant products, and in washing and cleaning sectors.
Keywords
16S RIBOSOMAL-RNA, GRADIENT GEL-ELECTROPHORESIS, POLYMERIZATION, NANOPARTICLES, ENCAPSULATION, MICROENCAPSULATION, MICROSPHERES, STABILITY, AGENT, OIL

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Chicago
Hosseinkhani, Baharak, Chris Callewaert, Nelleke Vanbeveren, and Nico Boon. 2015. “Novel Biocompatible Nanocapsules for Slow Release of Fragrances on the Human Skin.” New Biotechnology 32 (1): 40–46.
APA
Hosseinkhani, B., Callewaert, C., Vanbeveren, N., & Boon, N. (2015). Novel biocompatible nanocapsules for slow release of fragrances on the human skin. NEW BIOTECHNOLOGY, 32(1), 40–46.
Vancouver
1.
Hosseinkhani B, Callewaert C, Vanbeveren N, Boon N. Novel biocompatible nanocapsules for slow release of fragrances on the human skin. NEW BIOTECHNOLOGY. 2015;32(1):40–6.
MLA
Hosseinkhani, Baharak, Chris Callewaert, Nelleke Vanbeveren, et al. “Novel Biocompatible Nanocapsules for Slow Release of Fragrances on the Human Skin.” NEW BIOTECHNOLOGY 32.1 (2015): 40–46. Print.
@article{5839106,
  abstract     = {There is a growing demand for fragranced products, but due to the poor aqueous solubility and instability of fragrance molecules, their use is limited. Nowadays, fragrance encapsulation in biocompatible nanocontainer material is emerging as a novel strategy to overcome the evaporation of volatile molecules and to prolong the sensory characteristics of fragrance molecules and the longevity of perfumes. The objective of this study was to develop an innovative sustained release system of perfume, by entrapping fragrance molecules in a polymeric nanocarrier; the impact of this strategy on the human axillary microbiome was further assessed. Stabilised poly-L-lactic acid nanocapsules (PLA-NCs) with a diameter of approximately 115 nm were prepared through nanoprecipitation. Size and morphology of the capsules were evaluated using Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). Two model hydrophobic compounds, chlorobenzene and fluorescein, representing two different types of functionalised molecules, were encapsulated in PLA-NCs with an efficiency rate of 50\%. Different release behaviours were seen, dependent on hydrophobicity. For hydrophobic compounds, a steady release was observed over 48 hours. The polymeric nanocarriers did not impact the human axillary microbiome. Because of the slow and sustained release of fragrances, encapsulation of molecules in biocompatible NCs can represent a revolutionary contribution to the future of toiletries, body deodorant products, and in washing and cleaning sectors.},
  author       = {Hosseinkhani, Baharak and Callewaert, Chris and Vanbeveren, Nelleke and Boon, Nico},
  issn         = {1871-6784},
  journal      = {NEW BIOTECHNOLOGY},
  keyword      = {16S RIBOSOMAL-RNA,GRADIENT GEL-ELECTROPHORESIS,POLYMERIZATION,NANOPARTICLES,ENCAPSULATION,MICROENCAPSULATION,MICROSPHERES,STABILITY,AGENT,OIL},
  language     = {eng},
  number       = {1},
  pages        = {40--46},
  title        = {Novel biocompatible nanocapsules for slow release of fragrances on the human skin},
  url          = {http://dx.doi.org/10.1016/j.nbt.2014.09.001},
  volume       = {32},
  year         = {2015},
}

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