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Treatment of patellofemoral cartilage defects in the knee by autologous matrix-induced chondrogenesis (AMIC)

(2014) ACTA ORTHOPAEDICA BELGICA. 80(2). p.251-259
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Abstract
This study presents the prospective two-year clinical and MRI outcome of autologous matrix-induced chondrogenesis (AMIC) for the treatment of patellofemoral cartilage defects in the knee. Ten patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original and modified MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) scoring system. A satisfying clinical improvement became apparent during the 24 months of follow-up. The MOCART scoring system revealed a slight tendency to deterioration on MIRE between one and 2 years of follow-up. However, the difference was not statistical significant. All cases showed subchondral lamina changes. The formation of intralesional osteophytes was observed in 3 of the 10 patients (30%). In conclusion, AMIC is safe and feasible for the treatment of symptomatic patellofemoral cartilage defects and resulted in a clinical improvement. However, the favourable clinical outcome of the AMIC technique was not confirmed by the MIRE findings.
Keywords
VISUAL ANALOG SCALE, OUTCOME SCORE KOOS, FEMORAL JOINT MECHANICS, THICKNESS CHONDRAL DEFECTS, CHONDROCYTE IMPLANTATION, REPAIR TISSUE, FOLLOW-UP, MICROFRACTURE, ARTHROSCOPIES, TRANSPLANTATION

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Citation

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Chicago
Dhollander, Aad, Kris Moens, JAAP VAN DER MAAS, Peter Verdonk, Karl Almqvist, and Jan Victor. 2014. “Treatment of Patellofemoral Cartilage Defects in the Knee by Autologous Matrix-induced Chondrogenesis (AMIC).” Acta Orthopaedica Belgica 80 (2): 251–259.
APA
Dhollander, A., Moens, K., VAN DER MAAS, J., Verdonk, P., Almqvist, K., & Victor, J. (2014). Treatment of patellofemoral cartilage defects in the knee by autologous matrix-induced chondrogenesis (AMIC). ACTA ORTHOPAEDICA BELGICA, 80(2), 251–259.
Vancouver
1.
Dhollander A, Moens K, VAN DER MAAS J, Verdonk P, Almqvist K, Victor J. Treatment of patellofemoral cartilage defects in the knee by autologous matrix-induced chondrogenesis (AMIC). ACTA ORTHOPAEDICA BELGICA. 2014;80(2):251–9.
MLA
Dhollander, Aad, Kris Moens, JAAP VAN DER MAAS, et al. “Treatment of Patellofemoral Cartilage Defects in the Knee by Autologous Matrix-induced Chondrogenesis (AMIC).” ACTA ORTHOPAEDICA BELGICA 80.2 (2014): 251–259. Print.
@article{5837727,
  abstract     = {This study presents the prospective two-year clinical and MRI outcome of autologous matrix-induced chondrogenesis (AMIC) for the treatment of patellofemoral cartilage defects in the knee. Ten patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original and modified MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) scoring system. A satisfying clinical improvement became apparent during the 24 months of follow-up. The MOCART scoring system revealed a slight tendency to deterioration on MIRE between one and 2 years of follow-up. However, the difference was not statistical significant. All cases showed subchondral lamina changes. The formation of intralesional osteophytes was observed in 3 of the 10 patients (30%). In conclusion, AMIC is safe and feasible for the treatment of symptomatic patellofemoral cartilage defects and resulted in a clinical improvement. However, the favourable clinical outcome of the AMIC technique was not confirmed by the MIRE findings.},
  author       = {Dhollander, Aad and Moens, Kris and VAN DER MAAS, JAAP and Verdonk, Peter and Almqvist, Karl and Victor, Jan},
  issn         = {0001-6462},
  journal      = {ACTA ORTHOPAEDICA BELGICA},
  keywords     = {VISUAL ANALOG SCALE,OUTCOME SCORE KOOS,FEMORAL JOINT MECHANICS,THICKNESS CHONDRAL DEFECTS,CHONDROCYTE IMPLANTATION,REPAIR TISSUE,FOLLOW-UP,MICROFRACTURE,ARTHROSCOPIES,TRANSPLANTATION},
  language     = {eng},
  number       = {2},
  pages        = {251--259},
  title        = {Treatment of patellofemoral cartilage defects in the knee by autologous matrix-induced chondrogenesis (AMIC)},
  volume       = {80},
  year         = {2014},
}

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