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Reperfusion therapy and mortality in octogenarian STEMI patients: results from the Belgian STEMI registry

ELS VANDECASTEELE, MARC DE BUYZERE, SOFIE GEVAERT, Antoine de Meester, Carl Convens, Philippe Dubois, Jean Boland, Peter Sinnaeve, Herbert De Raedt, Pascal Vranckx, et al. (2013) CLINICAL RESEARCH IN CARDIOLOGY. 102(11). p.837-845
abstract
Treatment strategies and outcome of ST-elevation myocardial infarction (STEMI) have been mainly studied in middle-aged patients. With increasing lifetime expectancy, the proportion of octogenarians will substantially increase. We aimed to evaluate whether the benefit of currently recommended reperfusion strategies is maintained in octogenarians. Reperfusion therapy and in-hospital mortality were evaluated in 1,092 octogenarians and compared with 7,984 STEMI patients < 80 years old based on data from the prospective Belgian STEMI registry. The octogenarian STEMI group had more cardiovascular comorbidities, contained more female patients and presented more frequently with cardiac failure (Killip class > 1, 40 vs. 20 %) compared with their younger counterparts (all p < 0.05). Although the rate of thrombolysis was similar (9.2 vs. 9.9 %) between both groups, a conservative approach was chosen more frequently (13.8 vs. 4.7 %), while PCI was performed less frequently (76.9 vs. 85.4 %) in octogenarians (p < 0.001). Moreover, ischemic time and door-to-needle/balloon time were longer for octogenarians. In-hospital mortality for octogenarians was 17.8 vs. 5.5 % in the younger group [adjusted OR 2.43(1.92-3.08)]. In haemodynamically stable octogenarians, PCI seemed to improve outcome compared with thrombolysis or conservative treatment (5.7 vs. 12.7 vs. 8.5 %, p = 0.09). In octogenarians with cardiac failure, in-hospital mortality was extremely high independent of the chosen reperfusion therapy (34.6 vs. 31.6 vs. 36.3 %, p = 0.88). In-hospital mortality in octogenarian STEMI patients was high and related to a high prevalence of cardiac failure. Less PCI was performed in the octogenarian group compared with the younger patients, although mortality benefit of PCI was maintained in haemodynamically stable octogenarians.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ST-elevation myocardial infarction, Elderly, Reperfusion, ACUTE MYOCARDIAL-INFARCTION, ST-SEGMENT-ELEVATION, PERCUTANEOUS CORONARY INTERVENTION, IN-HOSPITAL MORTALITY, QUALITY-OF-CARE, ELDERLY-PATIENTS, PRIMARY ANGIOPLASTY, TERM OUTCOMES, AGE, THROMBOLYSIS
journal title
CLINICAL RESEARCH IN CARDIOLOGY
Clin. Res. Cardiol.
volume
102
issue
11
pages
837 - 845
Web of Science type
Article
Web of Science id
000325815700007
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
4.167 (2013)
JCR rank
26/125 (2013)
JCR quartile
1 (2013)
ISSN
1861-0684
DOI
10.1007/s00392-013-0600-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5835693
handle
http://hdl.handle.net/1854/LU-5835693
date created
2015-02-02 15:11:59
date last changed
2016-12-19 15:39:46
@article{5835693,
  abstract     = {Treatment strategies and outcome of ST-elevation myocardial infarction (STEMI) have been mainly studied in middle-aged patients. With increasing lifetime expectancy, the proportion of octogenarians will substantially increase. We aimed to evaluate whether the benefit of currently recommended reperfusion strategies is maintained in octogenarians. 
Reperfusion therapy and in-hospital mortality were evaluated in 1,092 octogenarians and compared with 7,984 STEMI patients {\textlangle} 80 years old based on data from the prospective Belgian STEMI registry. 
The octogenarian STEMI group had more cardiovascular comorbidities, contained more female patients and presented more frequently with cardiac failure (Killip class {\textrangle} 1, 40 vs. 20 \%) compared with their younger counterparts (all p {\textlangle} 0.05). Although the rate of thrombolysis was similar (9.2 vs. 9.9 \%) between both groups, a conservative approach was chosen more frequently (13.8 vs. 4.7 \%), while PCI was performed less frequently (76.9 vs. 85.4 \%) in octogenarians (p {\textlangle} 0.001). Moreover, ischemic time and door-to-needle/balloon time were longer for octogenarians. In-hospital mortality for octogenarians was 17.8 vs. 5.5 \% in the younger group [adjusted OR 2.43(1.92-3.08)]. In haemodynamically stable octogenarians, PCI seemed to improve outcome compared with thrombolysis or conservative treatment (5.7 vs. 12.7 vs. 8.5 \%, p = 0.09). In octogenarians with cardiac failure, in-hospital mortality was extremely high independent of the chosen reperfusion therapy (34.6 vs. 31.6 vs. 36.3 \%, p = 0.88). 
In-hospital mortality in octogenarian STEMI patients was high and related to a high prevalence of cardiac failure. Less PCI was performed in the octogenarian group compared with the younger patients, although mortality benefit of PCI was maintained in haemodynamically stable octogenarians.},
  author       = {VANDECASTEELE, ELS and DE BUYZERE, MARC and GEVAERT, SOFIE and de Meester, Antoine and Convens, Carl and Dubois, Philippe and Boland, Jean and Sinnaeve, Peter and De Raedt, Herbert and Vranckx, Pascal and Coussement, Patrick and Evrard, Patrick and Beauloye, Christophe and Renard, Marc and Claeys, Marc},
  issn         = {1861-0684},
  journal      = {CLINICAL RESEARCH IN CARDIOLOGY},
  keyword      = {ST-elevation myocardial infarction,Elderly,Reperfusion,ACUTE MYOCARDIAL-INFARCTION,ST-SEGMENT-ELEVATION,PERCUTANEOUS CORONARY INTERVENTION,IN-HOSPITAL MORTALITY,QUALITY-OF-CARE,ELDERLY-PATIENTS,PRIMARY ANGIOPLASTY,TERM OUTCOMES,AGE,THROMBOLYSIS},
  language     = {eng},
  number       = {11},
  pages        = {837--845},
  title        = {Reperfusion therapy and mortality in octogenarian STEMI patients: results from the Belgian STEMI registry},
  url          = {http://dx.doi.org/10.1007/s00392-013-0600-3},
  volume       = {102},
  year         = {2013},
}

Chicago
VANDECASTEELE, ELS, MARC DE BUYZERE, SOFIE GEVAERT, Antoine de Meester, Carl Convens, Philippe Dubois, Jean Boland, et al. 2013. “Reperfusion Therapy and Mortality in Octogenarian STEMI Patients: Results from the Belgian STEMI Registry.” Clinical Research in Cardiology 102 (11): 837–845.
APA
VANDECASTEELE, E., DE BUYZERE, M., GEVAERT, S., de Meester, A., Convens, C., Dubois, P., Boland, J., et al. (2013). Reperfusion therapy and mortality in octogenarian STEMI patients: results from the Belgian STEMI registry. CLINICAL RESEARCH IN CARDIOLOGY, 102(11), 837–845.
Vancouver
1.
VANDECASTEELE E, DE BUYZERE M, GEVAERT S, de Meester A, Convens C, Dubois P, et al. Reperfusion therapy and mortality in octogenarian STEMI patients: results from the Belgian STEMI registry. CLINICAL RESEARCH IN CARDIOLOGY. 2013;102(11):837–45.
MLA
VANDECASTEELE, ELS, MARC DE BUYZERE, SOFIE GEVAERT, et al. “Reperfusion Therapy and Mortality in Octogenarian STEMI Patients: Results from the Belgian STEMI Registry.” CLINICAL RESEARCH IN CARDIOLOGY 102.11 (2013): 837–845. Print.